EKS-SAC-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11346.83.1E-10410341310277
StatusReviewed
Ensembl ProteinYCR073C
UniProt AccessionP25390; D6VR75;
Protein NameSerine/threonine-protein kinase SSK22
Protein Synonyms/Alias MAP kinase kinase kinase SSK22; Suppressor of sensor kinase 22;
Gene NameSSK22
Gene Synonyms/Alias SSK22; YCR073C; YCR73C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YCR073CYCR073CYCR073C
OrganismSaccharomyces cerevisiae
Functional DescriptionKinase involved in a signal transduction pathway that isactivated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
Protein Length1331
Protein Sequence
(FASTA)
MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG GSETISDGPS 60
QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE DDGDDEIIRL SNGDRIDEDL 120
HSGVKFFSTT PYCRKMRSDS DELAWNEIAT ERFKWQSMLA RVLKGDIVKG EKTRIANQVK 180
KPGLNKELSD EIWLELKAWL NGRTMQEMEQ SLTYLRDSSD SVFEEIMKFQ IPQGKILSLD 240
ALEAILQDLM NRYHSVVSYW PNLKKMYKDK PITNTAEFTA RIDVMNSWLN FKTNLTLRRQ 300
ELDDWINRFS PISSSDNCQE DFDGVPQWNC KMKILAEQLM KEKNIESIFQ KKIFYPLSPW 360
MFKLKLHFIV YRETLTKMNI KYPYERLRSL LAFPVYLIKE VILTRLSYAR KLKNPTMMMI 420
DQMIDDFNAF IRLSVQLKYT LTKYCSNLPF DVDFDPTFEN TVIEAIRYLF FLLNLKLIDS 480
SKQNFKAPDL LLKYWDHLKN TGHYINGAET VIPNEFLKLT LRLVHKLQFY LLKQQNFPPT 540
FANASEAEKW LSSIFENLGA MKRKLNRFSN ILVKAFQNSA VYQINHNAQL VKKLKDAHYF 600
LVYSGNTFES SGVYMFAAPE LLGCDNDTIL RILRNKSIGC DLVPKLDIGN NLNVYDITTK 660
ETDLNILVSK GEDSKGIPYY RVVANSSSDL DRHAHQSKKK NFSTDPFDQH LDEKNNEVFE 720
LEVALSSLGA LVVLYPGEPV VWDGPVYKLP GNNLFASNEM DLGKIGNPNT LILLNQGSNY 780
ALTYQIDKFN QTVGDSVSFI EKRCSLNSIE SSLQKINKAY YKLTYTVLNN YKGILGSFMK 840
QCPGNELLNS IFMFGRDFGR SFLKYNAFSS KRKYVIIFLM VKLGMNWLKF LVEECDPTDQ 900
RTFRWCVLAM DFAMQMTSGY NILALNVKQF QELKERVSVC MSLLISHFDV MGARATEAEN 960
GMQQARLNID TEENIDEEAT LEINSRLRLE AIKTLEKTMK RNPRQMGKVL DATDQGNKYL 1020
LSLASSLSNV SMRWQKRSFI GGGTFGQVYS AINLENGEIL AVKEIKIHDT TTMKKIFPLI 1080
KEEMTVLEML NHPNIVQYYG VEVHRDKVNI FMEYCEGGSL ASLLDHGRIE DEMVTQVYTF 1140
ELLEGLAYLH QSGVVHRDIK PENILLDFNG IIKYVDFGTA RTVVGSRTRT VRNAAVQDFG 1200
VETKSLNEMM GTPMYMAPET ISGSAVKGKL GADDVWALGC VVLEMATGRR PWSNLDNEWA 1260
IMYHVAAGRI PQLPNRDEMT AAGRAFLERC LVQDPTMRAT AVELLIDPWM IQIREIAFGN 1320
SEKDQVPILS S 1331
Nucleotide Sequence
(FASTA)
ATGATGATGG ATATACTGAA TACACAGCAA CAAAAAGCGG CTGAAGGCGG GAGAGTTCTG 60
GCTCCTCATA CCATCTCAAG TAAGCTCGTG AAGAGATTAT CAAGTCATTC CAGCCATAAA 120
CTATCAAGAT CTGATTTGAA AGCATTGGGT GGCTCGGAAA CAATAAGCGA CGGCCCCAGT 180
CAGCTGACTT TTAAGGACCG ATACGTTTTC AATGAATCGC TATACTTGAA AAAGCTAAAA 240
AAGACCGCTT TAGATGACTA CTACACGAGG GGCATAAAAC TCACTAACCG CTACGAGGAA 300
GACGACGGTG ATGACGAAAT TATTCGGTTG TCTAATGGCG ACAGAATTGA TGAAGACCTG 360
CACTCAGGTG TCAAGTTTTT CTCCACTACA CCTTATTGCA GGAAAATGAG GTCAGACAGT 420
GATGAACTAG CTTGGAATGA AATTGCGACC GAACGGTTCA AATGGCAGTC AATGCTGGCC 480
AGAGTGCTGA AGGGAGATAT TGTTAAAGGT GAAAAGACGA GGATTGCTAA CCAAGTCAAG 540
AAACCAGGGT TAAATAAGGA GCTCTCAGAT GAGATATGGC TCGAATTGAA GGCATGGCTG 600
AATGGGAGGA CCATGCAAGA GATGGAACAG TCGCTTACAT ATTTAAGAGA TAGTTCAGAT 660
TCCGTTTTTG AAGAGATAAT GAAGTTTCAA ATTCCACAGG GCAAGATATT GAGCCTGGAT 720
GCACTGGAGG CCATCTTACA AGACCTCATG AACAGATATC ACAGCGTTGT CTCTTATTGG 780
CCTAACTTGA AAAAAATGTA TAAGGATAAA CCAATCACCA ATACTGCAGA ATTTACCGCT 840
AGAATAGACG TAATGAATTC TTGGCTGAAC TTTAAAACGA ACTTAACGTT GAGGAGGCAA 900
GAGTTGGACG ACTGGATAAA CCGTTTCTCA CCGATAAGTA GTTCGGATAA TTGCCAAGAG 960
GATTTTGATG GTGTGCCCCA ATGGAACTGC AAAATGAAGA TTCTTGCAGA ACAATTGATG 1020
AAGGAAAAGA ACATCGAGTC TATATTCCAA AAAAAAATTT TCTATCCGCT ATCACCTTGG 1080
ATGTTCAAAC TGAAACTACA TTTTATAGTC TACAGAGAAA CTTTGACAAA GATGAACATA 1140
AAATATCCTT ATGAAAGGTT AAGATCACTA CTGGCGTTCC CCGTCTATTT AATCAAAGAA 1200
GTTATTTTGA CTAGATTGTC ATATGCACGA AAGCTTAAAA ATCCAACAAT GATGATGATC 1260
GATCAAATGA TCGATGATTT TAACGCTTTT ATTCGACTTT CTGTGCAATT GAAGTACACA 1320
CTGACAAAAT ATTGCTCCAA TTTGCCGTTC GATGTGGATT TTGACCCGAC GTTCGAAAAT 1380
ACTGTAATAG AAGCCATTCG TTATTTATTT TTTCTGTTGA ATTTAAAGTT GATTGATTCC 1440
AGTAAACAAA ATTTCAAAGC ACCCGATCTA CTCTTGAAAT ACTGGGATCA CCTAAAAAAC 1500
ACCGGTCACT ATATTAACGG TGCAGAAACC GTGATTCCAA ATGAATTTCT CAAGTTAACT 1560
TTGAGACTCG TACATAAATT GCAATTCTAT CTTTTGAAAC AACAAAACTT CCCACCAACA 1620
TTTGCTAACG CTTCAGAAGC AGAAAAATGG CTAAGTTCCA TTTTCGAAAA TTTGGGTGCC 1680
ATGAAAAGAA AGCTGAACAG GTTCAGCAAT ATTCTAGTCA AGGCGTTCCA AAATTCTGCT 1740
GTTTATCAGA TTAATCATAA TGCACAACTT GTTAAAAAGT TAAAAGATGC TCACTATTTT 1800
TTGGTATACT CCGGTAACAC TTTTGAGTCT AGTGGTGTAT ATATGTTTGC TGCTCCTGAA 1860
TTATTAGGTT GTGACAATGA TACCATCTTA AGAATTTTGC GAAATAAATC CATTGGCTGT 1920
GATTTGGTCC CAAAGCTTGA CATTGGAAAT AATTTGAATG TGTATGATAT AACAACAAAA 1980
GAAACAGATT TGAACATTCT AGTATCGAAA GGGGAGGATT CCAAAGGAAT TCCTTACTAC 2040
CGAGTAGTAG CAAATTCGTC AAGTGATTTG GACAGGCATG CTCATCAGTC CAAAAAGAAG 2100
AATTTTTCAA CAGACCCTTT TGATCAGCAC CTTGATGAAA AGAACAATGA AGTTTTTGAA 2160
TTGGAAGTTG CTTTGAGCTC ATTGGGTGCA CTAGTTGTAC TATATCCTGG AGAGCCAGTA 2220
GTTTGGGATG GACCAGTATA TAAGCTTCCA GGTAACAACC TTTTTGCATC CAACGAAATG 2280
GATTTAGGGA AAATTGGTAA CCCAAATACG TTGATTTTAC TCAATCAAGG TTCTAATTAT 2340
GCACTGACTT ATCAAATCGA CAAGTTTAAT CAAACGGTAG GTGATTCTGT TTCATTCATA 2400
GAGAAACGTT GTTCACTCAA TTCAATTGAA TCCTCCCTAC AAAAAATCAA TAAGGCATAT 2460
TACAAACTTA CTTATACAGT ATTGAACAAC TACAAAGGAA TTCTAGGTAG CTTTATGAAG 2520
CAATGTCCGG GAAATGAGTT GTTAAATTCG ATATTCATGT TTGGAAGGGA TTTTGGAAGA 2580
AGTTTCCTTA AATATAACGC CTTTAGCTCA AAGAGGAAGT ACGTTATCAT CTTTCTGATG 2640
GTTAAATTAG GAATGAACTG GTTGAAATTC CTTGTTGAAG AGTGTGATCC TACCGATCAG 2700
CGAACTTTCC GATGGTGCGT TCTTGCAATG GATTTTGCGA TGCAGATGAC TAGTGGTTAT 2760
AATATCCTGG CGCTGAATGT AAAGCAATTT CAAGAACTGA AGGAGAGGGT ATCAGTATGT 2820
ATGTCATTAT TAATTTCACA TTTCGACGTT ATGGGTGCAC GAGCCACTGA AGCTGAAAAT 2880
GGCATGCAAC AGGCAAGATT GAATATTGAT ACTGAAGAGA ATATTGATGA AGAGGCCACC 2940
CTAGAAATAA ACAGCAGGTT GAGACTGGAA GCTATAAAGA CGTTGGAAAA GACTATGAAG 3000
AGGAATCCCA GGCAAATGGG TAAGGTATTG GATGCTACAG ATCAGGGAAA CAAATACCTA 3060
CTATCGCTAG CATCCTCATT ATCGAATGTA TCAATGAGGT GGCAAAAAAG AAGCTTCATT 3120
GGCGGTGGAA CATTTGGACA GGTATACTCT GCAATTAATC TGGAAAACGG TGAAATCTTA 3180
GCTGTTAAGG AAATAAAGAT ACACGATACC ACAACAATGA AGAAGATTTT TCCCCTGATT 3240
AAAGAAGAGA TGACCGTATT GGAAATGTTA AACCATCCTA ATATTGTCCA GTACTATGGT 3300
GTCGAAGTAC ATCGCGATAA AGTTAACATC TTCATGGAAT ACTGTGAGGG TGGTTCTTTA 3360
GCCTCGTTAT TGGATCATGG AAGAATTGAA GATGAAATGG TAACACAAGT GTACACATTC 3420
GAACTATTAG AAGGTTTGGC ATATTTGCAC CAATCTGGCG TGGTGCATCG CGACATTAAA 3480
CCGGAGAATA TCTTGCTGGA TTTCAATGGA ATCATAAAAT ATGTGGATTT TGGTACGGCA 3540
CGTACCGTTG TAGGATCTAG GACTAGAACT GTGCGGAACG CAGCCGTTCA AGATTTTGGA 3600
GTAGAAACAA AGTCCCTCAA TGAAATGATG GGGACACCGA TGTATATGGC TCCAGAGACT 3660
ATTTCAGGCT CGGCAGTTAA GGGAAAACTT GGAGCGGACG ATGTATGGGC ATTAGGATGT 3720
GTTGTGCTAG AAATGGCCAC AGGTAGACGA CCTTGGTCTA ACTTGGATAA TGAATGGGCC 3780
ATCATGTACC ACGTTGCTGC AGGTCGAATA CCGCAACTAC CCAATAGAGA CGAAATGACT 3840
GCAGCGGGAA GAGCCTTCTT GGAAAGGTGT TTGGTTCAAG ACCCCACTAT GAGGGCTACT 3900
GCTGTGGAAC TACTGATAGA CCCTTGGATG ATACAAATCC GTGAAATAGC ATTTGGCAAC 3960
TCAGAGAAAG ATCAAGTACC TATCCTAAGC TCATAG 3996
Domain Profile
S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60
         wqkr++ig G+fg+vy+a+++++ge+lavKe++i ++++++kk++  +keE+++l++l+H
Q: 1034  WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKI-HDTTTMKKIFPLIKEEMTVLEMLNH  1092
         99********************************.899999*******************
S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkle.esvikkytkqileglayLHe  119
         +niv+yyGvev++++++if+Ey+egGsl+sll+ +g++e e+v+++yt ++leglayLH+
Q: 1093  PNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLD-HGRIEdEMVTQVYTFELLEGLAYLHQ  1151
         ********************************9.9***999*******************
S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae.............lesltG  166
         +++vHRDiK++Nilld++g++k++DFG+++++  ++t++ +             l++++G
Q: 1152  SGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRnaavqdfgvetksLNEMMG  1211
         ***********************************999888788888888777777****
S: 167   tlaymaPEvikk.kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktk  225
         t++ymaPE+i++ + kg+  ++D+W+lgcvv+em+tg+rP+++ld+e+aim++v+a +  
Q: 1212  TPMYMAPETISGsAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGR-I  1270
         ************999*******************************************.*
S: 226   Peipek..lseegkdflekcleldpkkrpsaeeLLkhefl  263
         P++p++  ++++g++fle+cl +dp+ r++a eLL ++++
Q: 1271  PQLPNRdeMTAAGRAFLERCLVQDPTMRATAVELLIDPWM  1310
         ****9888*****************************996
Domain Sequence
(FASTA)
WQKRSFIGGG TFGQVYSAIN LENGEILAVK EIKIHDTTTM KKIFPLIKEE MTVLEMLNHP 60
NIVQYYGVEV HRDKVNIFME YCEGGSLASL LDHGRIEDEM VTQVYTFELL EGLAYLHQSG 120
VVHRDIKPEN ILLDFNGIIK YVDFGTARTV VGSRTRTVRN AAVQDFGVET KSLNEMMGTP 180
MYMAPETISG SAVKGKLGAD DVWALGCVVL EMATGRRPWS NLDNEWAIMY HVAAGRIPQL 240
PNRDEMTAAG RAFLERCLVQ DPTMRATAVE LLIDPWM 277
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000161; P:MAPK cascade involved in osmosensory signaling pathway
KEGG
sce:YCR073C;
InterPros
IPR011009; Kinase-like_dom.
IPR017240; MAPKKK_SSK22.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013