| Tag | Content |
|---|
| EKPD ID | EPS-SAC-00003 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPM/PP2C | 261.9 | 2.4E-78 | 26 | 279 | 254 |
|
| Status | Reviewed |
| Ensembl Protein | YDL006W |
| UniProt Accession | P35182; D6VRY2; |
| Protein Name | Protein phosphatase 2C homolog 1 |
| Protein Synonyms/Alias | PP2C-1; |
| Gene Name | PTC1 |
| Gene Synonyms/Alias | PTC1; TPD1; YDL006W; D2925; |
| Ensembl Information | |
| Organism | Saccharomyces cerevisiae |
| Functional Description | It has a serine and a weak tyrosine phosphatase activitywith ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation. |
| Protein Length | 281 |
Protein Sequence
(FASTA) | | MSNHSEILER PETPYDITYR VGVAENKNSK FRRTMEDVHT YVKNFASRLD WGYFAVFDGH 60 | | AGIQASKWCG KHLHTIIEQN ILADETRDVR DVLNDSFLAI DEEINTKLVG NSGCTAAVCV 120 | | LRWELPDSVS DDSMDLAQHQ RKLYTANVGD SRIVLFRNGN SIRLTYDHKA SDTLEMQRVE 180 | | QAGGLIMKSR VNGMLAVTRS LGDKFFDSLV VGSPFTTSVE ITSEDKFLIL ACDGLWDVID 240 | | DQDACELIKD ITEPNEAAKV LVRYALENGT TDNVTVMVVF L 281 |
|
Nucleotide Sequence
(FASTA) | | ATGAGTAATC ATTCTGAAAT CTTAGAAAGG CCAGAAACAC CATATGACAT AACTTATAGA 60 | | GTAGGTGTGG CGGAAAATAA AAACTCGAAA TTTCGGAGGA CAATGGAAGA TGTTCATACG 120 | | TATGTTAAAA ACTTTGCTTC AAGATTAGAT TGGGGATATT TCGCGGTGTT TGATGGACAT 180 | | GCTGGGATTC AGGCCTCCAA ATGGTGTGGT AAACATCTTC ATACAATTAT AGAGCAAAAC 240 | | ATTTTGGCAG ATGAAACACG AGATGTTAGA GATGTATTGA ACGATTCATT CCTAGCCATT 300 | | GACGAAGAAA TTAATACAAA ACTTGTAGGA AATAGTGGAT GTACTGCTGC TGTTTGCGTA 360 | | TTACGTTGGG AGCTTCCGGA TTCAGTTTCT GATGATTCAA TGGATTTAGC CCAACACCAA 420 | | AGAAAGTTAT ATACAGCAAA TGTTGGTGAT TCTCGAATAG TATTGTTTAG AAACGGGAAC 480 | | AGCATAAGAC TGACTTATGA TCATAAGGCA TCTGACACTT TGGAGATGCA GAGAGTTGAA 540 | | CAAGCAGGTG GCCTGATAAT GAAAAGTCGT GTAAATGGTA TGCTGGCAGT GACGAGATCG 600 | | TTAGGGGATA AATTTTTTGA TAGTTTAGTA GTGGGCAGCC CATTTACCAC GAGCGTAGAA 660 | | ATAACTTCTG AGGACAAATT TTTAATCCTA GCGTGTGATG GATTATGGGA TGTTATTGAT 720 | | GATCAAGATG CATGCGAATT AATCAAGGAT ATTACTGAAC CTAATGAAGC TGCAAAAGTC 780 | | TTGGTTAGAT ATGCTTTGGA AAATGGCACA ACAGATAATG TAACGGTCAT GGTTGTCTTC 840 | | CTCTAA 846 |
|
| Domain Profile | S: 6 vsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheilaeel 65 | + +++r++med +t+++nf+++ + + +f+v+DGh+g +++k+c ++lh+i+++++ | Q: 26 NKNSKFRRTMEDVHTYVKNFASRLD----WGYFAVFDGHAGIQASKWCGKHLHTIIEQNI 81 | 4567789**************9877....9*****************************8 |
| S: 66 esseseerkvkkalakaFlstdeelkvleeksldidksGstavvalik..........ds 115 | ++e+r+v+++l+++Fl++dee+ +++ +sG+ta v++++ ++ | Q: 82 L--ADETRDVRDVLNDSFLAIDEEI-----NTKLVGNSGCTAAVCVLRwelpdsvsddSM 134 | 8..99********************.....5568899***********888777776500 |
| S: 116 .......klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRv 168 | kly+anvGdSr+vL+rng++++l+ dHk+s + E++R+e+agg ++++ Rv | Q: 135 dlaqhqrKLYTANVGDSRIVLFRNGNSIRLTYDHKASDTLEMQRVEQAGGLIMKS---RV 191 | 5555668**********************************************99...** |
| S: 169 lGvLavsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdv 228 | +G+Lav+R+lGd++++++v+ +P +ts+++tsed+fliLa+DGlwdv+++++a++l++d+ | Q: 192 NGMLAVTRSLGDKFFDSLVVGSPFTTSVEITSEDKFLILACDGLWDVIDDQDACELIKDI 251 | ************************************************************ |
| S: 229 lekkeaeqeaakkLvklalargskdnvsaivv 260 | +e ++eaak Lv++al++g++dnv+++vv | Q: 252 TE----PNEAAKVLVRYALENGTTDNVTVMVV 279 | **....**********************9997 |
|
Domain Sequence
(FASTA) | | NKNSKFRRTM EDVHTYVKNF ASRLDWGYFA VFDGHAGIQA SKWCGKHLHT IIEQNILADE 60 | | TRDVRDVLND SFLAIDEEIN TKLVGNSGCT AAVCVLRWEL PDSVSDDSMD LAQHQRKLYT 120 | | ANVGDSRIVL FRNGNSIRLT YDHKASDTLE MQRVEQAGGL IMKSRVNGML AVTRSLGDKF 180 | | FDSLVVGSPF TTSVEITSED KFLILACDGL WDVIDDQDAC ELIKDITEPN EAAKVLVRYA 240 | | LENGTTDNVT VMVV 254 |
|
| Keyword | Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Stress response. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |