EKS-SAC-00052

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00052

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	372.5	5.3E-112	33	469	437

Status

Reviewed

Ensembl Protein

YDL017W

UniProt Accession

P06243; D6VRX3;

Protein Name

Cell division control protein 7

Protein Synonyms/Alias

Gene Name

CDC7

Gene Synonyms/Alias

CDC7; OAF2; YDL017W; D2855;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YDL017W	YDL017W	YDL017W

Organism

Saccharomyces cerevisiae

Functional Description

Serine/threonine-protein kinase. Needed for theinitiation of DNA synthesis during mitosis as well as for synaptomenal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.

Protein Length

507

Protein Sequence
(FASTA)

MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA KDITGKITKK 60

FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS SRVAPLCDAK RVRDQVIAVL 120

PYYPHEEFRT FYRDLPIKGI KKYIWELLRA LKFVHSKGII HRDIKPTNFL FNLELGRGVL 180

VDFGLAEAQM DYKSMISSQN DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP 240

PMVTIQNGKV VHLNNVNGVD LTKGYPKNET RRIKRANRAG TRGFRAPEVL MKCGAQSTKI 300

DIWSVGVILL SLLGRRFPMF QSLDDADSLL ELCTIFGWKE LRKCAALHGL GFEASGLIWD 360

KPNGYSNGLK EFVYDLLNKE CTIGTFPEYS VAFETFGFLQ QELHDRMSIE PQLPDPKTNM 420

DAVDAYELKK YQEEIWSDHY WCFQVLEQCF EMDPQKRSSA EDLLKTPFFN ELNENTYLLD 480

GESTDEDDVV SSSEADLLDK DVLLISE 507

Nucleotide Sequence
(FASTA)

ATGACAAGCA AAACGAAGAA TATCGATGAT ATACCTCCAG AAATCAAAGA AGAGATGATA 60

CAGCTCTATC ATGATCTACC GGGTATAGAA AATGAATATA AACTCATAGA CAAGATCGGT 120

GAGGGAACAT TTTCGTCAGT GTATAAAGCC AAAGATATCA CTGGGAAAAT AACAAAAAAA 180

TTTGCATCAC ATTTTTGGAA TTATGGTTCG AACTATGTTG CTTTGAAGAA AATATACGTT 240

ACCTCGTCAC CGCAAAGAAT TTATAATGAG CTCAACCTGC TGTACATAAT GACGGGATCT 300

TCGAGAGTAG CCCCTCTATG TGATGCAAAA AGGGTGCGAG ATCAAGTCAT TGCTGTTTTA 360

CCGTACTATC CCCACGAGGA GTTCCGAACT TTCTACAGGG ATCTACCAAT CAAGGGAATC 420

AAGAAGTACA TTTGGGAGCT ACTAAGAGCA TTGAAGTTTG TTCATTCGAA GGGAATTATT 480

CATAGAGACA TCAAACCGAC AAATTTTTTA TTTAATTTGG AATTGGGGCG TGGAGTGCTT 540

GTTGATTTTG GTCTAGCCGA GGCTCAAATG GATTATAAAA GCATGATATC TAGTCAAAAC 600

GATTACGACA ATTATGCAAA TACAAACCAT GATGGTGGAT ATTCAATGAG GAATCACGAA 660

CAATTTTGTC CATGCATTAT GCGTAATCAA TATTCTCCTA ACTCACATAA CCAAACACCT 720

CCTATGGTCA CCATACAAAA TGGCAAGGTC GTCCACTTAA ACAATGTAAA TGGGGTGGAT 780

CTGACAAAGG GTTATCCTAA AAATGAAACG CGTAGAATTA AAAGGGCTAA TAGAGCAGGG 840

ACTCGTGGAT TTCGGGCACC AGAAGTGTTA ATGAAGTGTG GGGCTCAAAG CACAAAGATT 900

GATATATGGT CCGTAGGTGT TATTCTTTTA AGTCTTTTGG GCAGAAGATT TCCAATGTTC 960

CAAAGTTTAG ATGATGCGGA TTCTTTGCTA GAGTTATGTA CTATTTTTGG TTGGAAAGAA 1020

TTAAGAAAAT GCGCAGCGTT GCATGGATTG GGTTTCGAAG CTAGTGGGCT CATTTGGGAT 1080

AAACCAAACG GATATTCTAA TGGATTGAAG GAATTTGTTT ATGATTTGCT TAATAAAGAA 1140

TGTACCATAG GTACGTTCCC TGAGTACAGT GTTGCTTTTG AAACATTCGG ATTTCTACAA 1200

CAAGAATTAC ATGACAGGAT GTCCATTGAA CCTCAATTAC CTGACCCCAA GACAAATATG 1260

GATGCTGTTG ATGCCTATGA GTTGAAAAAG TATCAAGAAG AAATTTGGTC CGATCATTAT 1320

TGGTGCTTCC AGGTTTTGGA ACAATGCTTC GAAATGGATC CTCAAAAGCG TAGTTCAGCA 1380

GAAGATTTAC TGAAAACCCC GTTTTTCAAT GAATTGAATG AAAACACATA TTTACTGGAT 1440

GGCGAGAGTA CTGACGAAGA TGACGTTGTC AGCTCAAGCG AGGCAGATTT GCTCGATAAG 1500

GATGTTCTCC TAATATCTGA ATAG 1524

Domain Profile

S: 1     fkikdkiGeGtfssvyla.......taqleeglee....kialkhliptshPeriaaeLe  49

         +k+ dkiGeGtfssvy+a       t+++++++++    ++alk++++ts+P+ri++eL+

Q: 33    YKLIDKIGEGTFSSVYKAkditgkiTKKFASHFWNygsnYVALKKIYVTSSPQRIYNELN  92

         89********************************999999********************

S: 50    lltvlgGqenvvglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalk  109

         ll++++G+++v++l++++r++d+v++vlpy++he+f++++r+l+++ +++Y+++Ll+alk

Q: 93    LLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALK  152

         ************************************************************

S: 110   rvhkfgivhrDvkpsnfLynrrlkkfaLvDfGLaq..seaqkeecsrnllsaavekevd.  166

         +vh++gi+hrD+kp+nfL+n +l++ +LvDfGLa+   + +    s+n   + ++++ d

Q: 153   FVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEaqMDYKSMISSQNDYDNYANTNHDg  212

         *********************************993323333445666666666666668

S: 167   ........................................tcdcygtd..kvcsvclsrr  184

                                                   + +g d  k      +rr

Q: 213   gysmrnheqfcpcimrnqyspnshnqtppmvtiqngkvvhLNNVNGVDltKGYPKNETRR  272

         88888888888888888888889999999999999998884555555511445556789*

S: 185   qqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgryPffkasddlealaei  244

         +++anraGt+GfraPevL+k+++q+t+iDiws+GvilLsll++r+P+f++ dd+++l+e+

Q: 273   IKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLEL  332

         ************************************************************

S: 245   vtilGsreiikaakafgksvllskevp.................................  271

         +ti+G++e++k+a  +g+    s  +

Q: 333   CTIFGWKELRKCAALHGLGFEASGLIWdkpngysnglkefvydllnkectigtfpeysva  392

         *******************99999887888******************************

S: 272   ...........................................dsdsyePdeaydlldkl  288

                                                    +sd+y+   ++++l+++

Q: 393   fetfgflqqelhdrmsiepqlpdpktnmdavdayelkkyqeeiWSDHYW---CFQVLEQC  449

         *************************************************...********

S: 289   lelnPakritaeealkhpff  308

         +e++P+kr++ae++lk+pff

Q: 450   FEMDPQKRSSAEDLLKTPFF  469

         *******************8

Domain Sequence
(FASTA)

YKLIDKIGEG TFSSVYKAKD ITGKITKKFA SHFWNYGSNY VALKKIYVTS SPQRIYNELN 60

LLYIMTGSSR VAPLCDAKRV RDQVIAVLPY YPHEEFRTFY RDLPIKGIKK YIWELLRALK 120

FVHSKGIIHR DIKPTNFLFN LELGRGVLVD FGLAEAQMDY KSMISSQNDY DNYANTNHDG 180

GYSMRNHEQF CPCIMRNQYS PNSHNQTPPM VTIQNGKVVH LNNVNGVDLT KGYPKNETRR 240

IKRANRAGTR GFRAPEVLMK CGAQSTKIDI WSVGVILLSL LGRRFPMFQS LDDADSLLEL 300

CTIFGWKELR KCAALHGLGF EASGLIWDKP NGYSNGLKEF VYDLLNKECT IGTFPEYSVA 360

FETFGFLQQE LHDRMSIEPQ LPDPKTNMDA VDAYELKKYQ EEIWSDHYWC FQVLEQCFEM 420

DPQKRSSAED LLKTPFF 437

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Magnesium; Meiosis; Metal-binding; Mitosis; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0031431	; C:Dbf4-dependent protein kinase complex
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051301	; P:cell division
GO:0006270	; P:DNA replication initiation
GO:0000727	; P:double-strand break repair via break-induced replication
GO:0007126	; P:meiosis
GO:0007067	; P:mitosis
GO:0001100	; P:negative regulation of exit from mitosis
GO:0031938	; P:regulation of chromatin silencing at telomere

KEGG

sce:YDL017W

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013