EPS-SAC-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2A	406.1	6.8E-123	119	311	193

Status

Reviewed

Ensembl Protein

YDL188C

UniProt Accession

P23595; D6VRG5;

Protein Name

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Protein Synonyms/Alias

Gene Name

PPH22

Gene Synonyms/Alias

PPH22; SIS4; YDL188C; D1271;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YDL188C	YDL188C	YDL188C

Organism

Saccharomyces cerevisiae

Functional Description

Exact function not known, phosphatase 2A performs anessential cellular function.

Protein Length

377

Protein Sequence
(FASTA)

MDMEIDDPMH GSDEDQLSPT LDEDMNSDDG KNNTKARSND EDTDEELEDF NFKPGSSGIA 60

DHKSSKPLKL TNTNINQLDQ WIEHLSKCEP LSEDDVARLC KMAVDVLQFE ENVKPINVPV 120

TICGDVHGQF HDLLELFKIG GPCPDTNYLF MGDYVDRGYY SVETVSYLVA MKVRYPHRIT 180

ILRGNHESRQ ITQVYGFYDE CLRKYGSANV WKMFTDLFDY FPVTALVDNK IFCLHGGLSP 240

MIETIDQVRD LNRIQEVPHE GPMCDLLWSD PDDRGGWGIS PRGAGFTFGQ DISEQFNHTN 300

DLSLIARAHQ LVMEGYSWSH QQNVVTIFSA PNYCYRCGNQ AAIMEVDENH NRQFLQYDPS 360

VRPGEPTVTR KTPDYFL 377

Nucleotide Sequence
(FASTA)

ATGGATATGG AAATTGATGA CCCTATGCAT GGTTCAGATG AAGATCAATT ATCACCGACT 60

CTCGACGAAG ACATGAATAG TGATGACGGC AAAAATAATA CGAAGGCGCG TTCTAATGAC 120

GAAGACACAG ATGAAGAGTT GGAAGATTTT AATTTTAAAC CGGGGTCCTC GGGTATAGCA 180

GATCATAAAT CCTCCAAACC ACTAAAACTG ACCAATACAA ATATAAATCA GCTTGACCAA 240

TGGATTGAGC ATTTGAGTAA ATGCGAGCCA CTATCAGAAG ACGATGTAGC ACGACTATGT 300

AAAATGGCGG TGGACGTGTT GCAGTTCGAG GAGAATGTTA AACCAATTAA CGTGCCTGTT 360

ACCATTTGTG GTGACGTACA CGGTCAATTC CATGACTTGT TAGAACTTTT CAAGATTGGT 420

GGTCCTTGTC CTGACACCAA TTACCTTTTC ATGGGTGATT ACGTGGATAG AGGATATTAT 480

TCTGTTGAGA CCGTATCTTA CCTAGTTGCC ATGAAAGTCA GATATCCACA TAGAATTACT 540

ATACTTAGGG GCAATCACGA GTCTAGGCAG ATTACCCAAG TATATGGGTT TTATGACGAA 600

TGTTTGAGAA AGTACGGCAG TGCGAACGTG TGGAAAATGT TTACCGATCT ATTCGATTAT 660

TTCCCCGTTA CTGCCTTGGT GGATAATAAA ATCTTCTGTT TGCATGGAGG TCTCTCACCC 720

ATGATAGAGA CAATAGATCA AGTTAGAGAT TTAAATAGAA TACAGGAAGT GCCTCACGAA 780

GGTCCAATGT GTGACCTTCT ATGGTCCGAT CCTGATGATA GAGGCGGATG GGGAATCAGT 840

CCGAGAGGTG CAGGCTTCAC TTTTGGTCAA GACATCAGTG AGCAATTCAA TCACACTAAT 900

GACCTATCAC TAATAGCAAG AGCTCACCAA TTGGTAATGG AAGGATATTC TTGGTCTCAC 960

CAGCAAAATG TTGTCACCAT TTTCAGTGCT CCAAATTATT GTTATAGATG TGGTAACCAG 1020

GCCGCTATTA TGGAGGTGGA TGAAAACCAT AATAGGCAAT TCTTACAATA CGATCCATCT 1080

GTGAGACCCG GTGAACCAAC CGTCACCAGG AAGACACCGG ATTATTTCTT ATAA 1134

Domain Profile

S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60

         pvt+cgdvhgqfhdllelf+igg +pdtnylf+gdyvdrgyysvetv++lva+kvry++r

Q: 119   PVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHR  178

         9***********************************************************

S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120

         itilrgnhesrqitqvygfydeclrkyg+anvwk+ftdlfdy+p+talvd+kifclhggl

Q: 179   ITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGL  238

         ************************************************************

S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180

         sp+i+t+d++r+l+r+qevphegp+cdllwsdpddr+gwgisprgag+tfgqdiseqfnh

Q: 239   SPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNH  298

         ************************************************************

S: 181   angleliarahql  193

         +n+l+liarahql

Q: 299   TNDLSLIARAHQL  311

         ************8

Domain Sequence
(FASTA)

PVTICGDVHG QFHDLLELFK IGGPCPDTNY LFMGDYVDRG YYSVETVSYL VAMKVRYPHR 60

ITILRGNHES RQITQVYGFY DECLRKYGSA NVWKMFTDLF DYFPVTALVD NKIFCLHGGL 120

SPMIETIDQV RDLNRIQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGFTF GQDISEQFNH 180

TNDLSLIARA HQL 193

Keyword

Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007015	; P:actin filament organization
GO:0007117	; P:budding cell bud growth
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0006470	; P:protein dephosphorylation
GO:0006417	; P:regulation of translation

KEGG

sce:YDL188C

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013