EPS-SAC-00004

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00004

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	241.6	3.8E-72	24	290	267

Status

Reviewed

Ensembl Protein

YER089C

UniProt Accession

P39966; D3DLZ6;

Protein Name

Protein phosphatase 2C homolog 2

Protein Synonyms/Alias

PP2C-2;

Gene Name

PTC2

Gene Synonyms/Alias

PTC2; YER089C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YER089C	YER089C	YER089C

Organism

Saccharomyces cerevisiae

Functional Description

Responsible, together with PTC3, for thedephosphorylation of the cyclin-dependent protein kinase CDC28.

Protein Length

464

Protein Sequence
(FASTA)

MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS DKDHIAFYGI 60

FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF INTDVKLLQD PVMKEDHSGC 120

TATSILVSKS QNLLVCGNAG DSRTVLATDG NAKALSYDHK PTLASEKSRI VAADGFVEMD 180

RVNGNLALSR AIGDFEFKSN PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL 240

TSQDCVDLVH LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA 300

QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK FTRDHEAAVA 360

SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID LASLEALLGA TGGVKTDSNG 420

NKVTYTLPQS ALAQLLQTMG HDPASSHPEN DSNTDHKAGR SHLQ 464

Nucleotide Sequence
(FASTA)

ATGGGACAAA TTCTATCAAA CCCGGTAATT GATAAAGAGA GCCACTCCGG TGCTGACTCC 60

TTGACCGCGT TTGGACTGTG TGCAATGCAA GGGTGGCGGA TGTCAATGGA GGATTCACAC 120

ATTCTAGAGC CTAATGTTTT GACAAAGTCC GATAAGGACC ATATTGCATT TTACGGTATA 180

TTCGATGGTC ATGGTGGCGC TAAAGTAGCA GAATACTGTG GTAATAAAAT AGTGGAGATC 240

CTGCAAGAGC AGAAATCGTT CCATGAAGGA AATTTACCAA GGGCTTTGAT TGATACTTTC 300

ATAAACACAG ACGTGAAACT GTTACAAGAT CCTGTGATGA AAGAAGACCA TAGCGGATGT 360

ACGGCTACAT CCATATTAGT ATCAAAGTCC CAGAACTTGT TAGTATGTGG TAACGCTGGT 420

GACAGTAGAA CCGTACTCGC CACCGACGGG AACGCAAAGG CATTATCATA CGATCACAAG 480

CCCACTCTAG CAAGCGAAAA ATCACGTATT GTGGCAGCTG ATGGCTTCGT AGAAATGGAT 540

AGGGTCAACG GTAACTTGGC GCTCTCTCGT GCCATTGGTG ATTTTGAGTT CAAATCCAAC 600

CCCAAATTGG GCCCCGAGGA GCAAATAGTG ACATGTGTTC CGGACATTCT CGAGCATTCT 660

CTAGATTACG ATAGGGACGA GTTTGTAATC TTAGCCTGTG ATGGTATCTG GGATTGTTTG 720

ACTTCCCAAG ATTGTGTGGA CTTGGTTCAT CTCGGCCTTC GCGAAGGCAA GACATTGAAT 780

GAAATTTCTT CGCGGATCAT CGATGTCTGT TGTGCTCCCA CCACAGAGGG GACGGGTATT 840

GGATGCGACA ACATGAGTAT AGTGGTTGTC GCGCTGCTGA AAGAAGGTGA AGACGTCGCT 900

CAATGGAGCG ACCGTATGAA GTCCAAGGCC CACCGCACAT CAGTGCGTTC TTTTGCAGAC 960

AAGAGAAGAA GGGTGTTTAG TTACTACGAT TTTTCCAAAT GTAACGACGA ACAGGTGTTC 1020

GCTATCACTA CGAAGAAACC TCAGGACAAA TTCACTCGCG ACCACGAAGC CGCTGTGGCC 1080

TCGGTGACTG CCGCCGATAA CGACGATCCA ATGGACATAG ACGACACGGA CGCTGACACA 1140

GATGCAGAAA ATCTTGACCC TTCCAGCCAA TCCAAGAGCA AGACCTCCGG CCCCATTGAT 1200

CTAGCATCCT TGGAGGCGCT ACTTGGTGCT ACAGGAGGAG TGAAGACAGA CAGCAACGGG 1260

AACAAAGTCA CCTACACTCT TCCCCAGTCT GCCTTGGCCC AACTGCTCCA AACCATGGGC 1320

CATGACCCGG CTTCCTCCCA TCCCGAGAAT GACAGTAACA CTGACCACAA GGCCGGCCGT 1380

TCCCACTTGC AATGA 1395

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         +g+++++g+r +med++ ++pn+l +++k + +af+g++DGhgg +va++c +k+ eil+

Q: 24    FGLCAMQGWRMSMEDSHILEPNVLTKSDKDH-IAFYGIFDGHGGAKVAEYCGNKIVEILQ  82

         7999**********************99866.9***************************

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds..klyva  120

         e+++    +e ++ +al ++F++td +l  l+++ +++d+sG+ta+ +l+++s   l++

Q: 83    EQKS---FHEGNLPRALIDTFINTDVKL--LQDPVMKEDHSGCTATSILVSKSqnLLVCG  137

         **99...57999****************..*********************998556669

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd  180

         n+GdSr+vL+ +g+a++ls dHkp+  +E++Ri +a+g v+ +   Rv+G+La+sRa+Gd

Q: 138   NAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMD---RVNGNLALSRAIGD  194

         *****************************************99...**************

S: 181   lylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvle  230

         +++k         ++vt+ P++ +h l+ + + f+iLa+DG+wd+++++++v+lv+  l+

Q: 195   FEFKsnpklgpeeQIVTCVPDILEHSLDYDRDeFVILACDGIWDCLTSQDCVDLVHLGLR  254

         ***************************887777***************************

S: 231   kkeaeqeaakkLvklalargsk......dnvsaivv  260

         ++++++e++++++++++a  ++      dn+s++vv

Q: 255   EGKTLNEISSRIIDVCCAPTTEgtgigcDNMSIVVV  290

         **********************999******99987

Domain Sequence
(FASTA)

FGLCAMQGWR MSMEDSHILE PNVLTKSDKD HIAFYGIFDG HGGAKVAEYC GNKIVEILQE 60

QKSFHEGNLP RALIDTFINT DVKLLQDPVM KEDHSGCTAT SILVSKSQNL LVCGNAGDSR 120

TVLATDGNAK ALSYDHKPTL ASEKSRIVAA DGFVEMDRVN GNLALSRAIG DFEFKSNPKL 180

GPEEQIVTCV PDILEHSLDY DRDEFVILAC DGIWDCLTSQ DCVDLVHLGL REGKTLNEIS 240

SRIIDVCCAP TTEGTGIGCD NMSIVVV 267

Keyword

Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000077	; P:DNA damage checkpoint
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0000173	; P:inactivation of MAPK activity involved in osmosensory signaling pathway
GO:0006470	; P:protein dephosphorylation
GO:0000079	; P:regulation of cyclin-dependent protein kinase activity

KEGG

sce:YER089C

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013