EKS-SAC-00054
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00054
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IRE436.89.6E-132675980306
StatusReviewed
Ensembl ProteinYHR079C
UniProt AccessionP32361; D3DL29;
Protein NameEndoribonuclease
Protein Synonyms/Alias Endoplasmic reticulum-to-nucleus signaling 1;
Gene NameIRE1
Gene Synonyms/Alias IRE1; ERN1; YHR079C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YHR079CYHR079CYHR079C
OrganismSaccharomyces cerevisiae
Functional DescriptionSenses unfolded proteins in the lumen of the endoplasmicreticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.
Protein Length1115
Protein Sequence
(FASTA)
MRLLRRNMLV LTLLVCVFSS IISCSIPLSS RTSRRQIVED EVASTKKLNF NYGVDKNINS 60
PIPAPRTTEG LPNMKLSSYP TPNLLNTADN RRANKKGRRA ANSISVPYLE NRSLNELSLS 120
DILIAADVEG GLHAVDRRNG HIIWSIEPEN FQPLIEIQEP SRLETYETLI IEPFGDGNIY 180
YFNAHQGLQK LPLSIRQLVS TSPLHLKTNI VVNDSGKIVE DEKVYTGSMR TIMYTINMLN 240
GEIISAFGPG SKNGYFGSQS VDCSPEEKIK LQECENMIVI GKTIFELGIH SYDGASYNVT 300
YSTWQQNVLD VPLALQNTFS KDGMCIAPFR DKSLLASDLD FRIARWVSPT FPGIIVGLFD 360
VFNDLRTNEN ILVPHPFNPG DHESISSNKV YLDQTSNLSW FALSSQNFPS LVESAPISRY 420
ASSDRWRVSS IFEDETLFKN AIMGVHQIYN NEYDHLYENY EKTNSLDTTH KYPPLMIDSS 480
VDTTDLHQNN EMNSLKEYMS PEDLEAYRKK IHEQISRELD EKNQNSLLLK FGSLVYRIIE 540
TGVFLLLFLI FCAILQRFKI LPPLYVLLSK IGFMPEKEIP IVESKSLNCP SSSENVTKPF 600
DMKSGKQVVF EGAVNDGSLK SEKDNDDADE DDEKSLDLTT EKKKRKRGSR GGKKGRKSRI 660
ANIPNFEQSL KNLVVSEKIL GYGSSGTVVF QGSFQGRPVA VKRMLIDFCD IALMEIKLLT 720
ESDDHPNVIR YYCSETTDRF LYIALELCNL NLQDLVESKN VSDENLKLQK EYNPISLLRQ 780
IASGVAHLHS LKIIHRDLKP QNILVSTSSR FTADQQTGAE NLRILISDFG LCKKLDSGQS 840
SFRTNLNNPS GTSGWRAPEL LEESNNLQCQ VETEHSSSRH TVVSSDSFYD PFTKRRLTRS 900
IDIFSMGCVF YYILSKGKHP FGDKYSRESN IIRGIFSLDE MKCLHDRSLI AEATDLISQM 960
IDHDPLKRPT AMKVLRHPLF WPKSKKLEFL LKVSDRLEIE NRDPPSALLM KFDAGSDFVI 1020
PSGDWTVKFD KTFMDNLERY RKYHSSKLMD LLRALRNKYH HFMDLPEDIA ELMGPVPDGF 1080
YDYFTKRFPN LLIGVYMIVK ENLSDDQILR EFLYS 1115
Nucleotide Sequence
(FASTA)
ATGCGTCTAC TTCGAAGAAA CATGTTAGTA TTGACACTGC TCGTTTGTGT GTTTTCATCC 60
ATCATTTCAT GCTCAATCCC ATTGTCGTCT CGCACCTCAA GGCGGCAGAT AGTGGAAGAT 120
GAAGTTGCCT CCACTAAAAA GCTCAATTTC AACTATGGTG TGGATAAAAA TATAAACTCG 180
CCCATTCCTG CTCCAAGAAC CACTGAAGGT TTACCAAATA TGAAACTCAG CTCATATCCA 240
ACTCCTAACT TATTGAATAC TGCTGATAAT CGACGTGCTA ACAAAAAAGG ACGTAGGGCT 300
GCCAATTCTA TAAGTGTACC CTATTTGGAG AATCGTTCCT TGAACGAACT GAGTTTATCA 360
GATATACTAA TCGCAGCCGA CGTTGAGGGT GGACTTCATG CTGTAGATAG AAGAAATGGT 420
CATATCATAT GGTCAATCGA ACCAGAAAAT TTTCAACCTC TGATAGAAAT ACAAGAACCT 480
TCGAGGTTAG AAACATATGA AACGTTGATT ATAGAACCTT TCGGTGATGG GAACATTTAC 540
TACTTTAACG CCCATCAAGG GTTACAAAAA CTGCCTTTAT CCATACGACA ACTTGTATCA 600
ACTTCCCCGC TGCACTTGAA AACAAATATT GTGGTTAATG ACTCTGGAAA AATTGTTGAA 660
GATGAAAAGG TCTACACTGG ATCGATGAGA ACTATAATGT ATACTATAAA CATGTTGAAT 720
GGTGAAATTA TATCAGCGTT CGGACCTGGT TCAAAAAACG GGTATTTCGG GAGCCAGAGT 780
GTGGATTGCT CACCTGAGGA GAAGATAAAA CTTCAGGAAT GTGAAAATAT GATTGTAATA 840
GGCAAAACTA TTTTTGAGCT GGGAATTCAC TCTTATGATG GAGCAAGCTA CAATGTCACT 900
TACTCTACAT GGCAGCAAAA TGTTTTAGAT GTTCCCCTAG CGCTTCAGAA TACATTTTCA 960
AAGGACGGCA TGTGCATAGC GCCTTTCCGT GATAAATCAT TGCTAGCAAG CGATTTAGAT 1020
TTTAGAATTG CTAGATGGGT TTCTCCGACA TTCCCCGGAA TTATTGTTGG GCTTTTCGAT 1080
GTGTTTAATG ATCTCCGCAC CAATGAAAAT ATACTGGTAC CGCATCCCTT TAATCCTGGT 1140
GATCATGAAA GTATATCGAG TAACAAAGTT TACTTGGATC AGACTTCGAA CCTCTCCTGG 1200
TTTGCATTAT CTAGTCAGAA TTTTCCATCT TTAGTCGAAT CAGCTCCCAT ATCAAGATAC 1260
GCTTCCAGTG ACCGTTGGAG GGTGTCTTCA ATTTTTGAAG ATGAGACTTT ATTCAAGAAC 1320
GCAATCATGG GTGTTCATCA GATATATAAT AATGAATATG ATCACCTTTA TGAAAACTAT 1380
GAAAAAACGA ATAGTTTGGA CACTACGCAC AAATATCCAC CTCTGATGAT TGATTCGTCC 1440
GTTGATACAA CCGATTTACA TCAGAATAAC GAGATGAATT CACTAAAGGA ATACATGTCA 1500
CCAGAAGACC TTGAGGCATA TAGAAAAAAG ATACACGAGC AAATATCGAG AGAATTAGAT 1560
GAAAAGAACC AAAATTCTTT GCTACTGAAG TTTGGAAGTC TAGTATATCG AATTATAGAG 1620
ACTGGAGTAT TTCTGTTGTT ATTTCTCATT TTTTGTGCAA TACTACAAAG ATTCAAAATT 1680
TTGCCGCCAC TATATGTATT ATTATCCAAA ATTGGATTTA TGCCTGAAAA GGAAATCCCC 1740
ATAGTTGAGT CGAAATCGCT AAATTGTCCC TCTTCATCGG AAAATGTAAC CAAGCCATTC 1800
GATATGAAAT CAGGGAAGCA AGTTGTTTTT GAAGGTGCTG TGAACGATGG AAGTCTAAAA 1860
TCTGAAAAAG ATAACGATGA TGCTGATGAA GATGATGAAA AATCACTAGA TTTAACCACA 1920
GAAAAGAAGA AGAGGAAAAG AGGTTCGAGA GGAGGCAAAA AGGGCCGAAA ATCACGCATT 1980
GCAAATATAC CAAACTTTGA GCAATCTTTA AAAAATTTGG TAGTATCCGA AAAAATTTTA 2040
GGTTACGGTT CATCAGGAAC AGTAGTTTTT CAGGGAAGTT TTCAAGGAAG ACCTGTTGCG 2100
GTAAAGAGAA TGTTAATTGA TTTTTGTGAC ATAGCTTTAA TGGAAATAAA ACTTTTGACT 2160
GAAAGCGATG ATCACCCTAA CGTCATACGA TACTACTGTT CAGAAACAAC AGACAGATTT 2220
TTGTATATTG CTTTAGAGCT CTGCAATTTG AACCTTCAAG ATTTGGTGGA GTCTAAGAAT 2280
GTATCAGATG AAAACCTGAA ATTACAGAAA GAGTATAATC CAATTTCGTT ATTGAGACAA 2340
ATAGCGTCCG GGGTAGCACA TTTACATTCT TTAAAGATTA TCCATCGAGA TTTAAAGCCT 2400
CAAAATATTC TCGTTTCTAC TTCGAGTAGG TTTACTGCCG ATCAGCAAAC AGGAGCAGAA 2460
AATCTTCGAA TTTTGATATC AGACTTTGGT CTTTGCAAAA AACTAGACTC TGGTCAGTCT 2520
TCATTTAGAA CAAATTTGAA TAACCCTTCT GGCACAAGTG GTTGGAGGGC CCCAGAGCTG 2580
CTTGAAGAAT CAAACAATTT GCAGTGCCAA GTCGAAACGG AACACTCTTC TAGTAGGCAT 2640
ACAGTAGTTT CATCTGATTC TTTTTATGAT CCGTTCACCA AGAGGAGGCT AACAAGATCT 2700
ATTGATATTT TTTCTATGGG ATGTGTATTC TATTATATCC TATCCAAAGG GAAGCATCCA 2760
TTTGGAGATA AATATTCACG TGAAAGCAAT ATCATAAGAG GAATATTCAG TCTTGATGAA 2820
ATGAAATGTC TACATGATAG ATCCTTAATT GCAGAAGCTA CAGATCTGAT CTCCCAAATG 2880
ATTGATCACG ATCCGTTAAA AAGACCTACT GCTATGAAAG TTCTAAGGCA TCCGTTGTTT 2940
TGGCCAAAGT CGAAAAAATT GGAGTTCCTT TTAAAAGTTA GTGATAGGCT TGAAATTGAA 3000
AACAGAGACC CTCCAAGTGC CCTGTTAATG AAATTTGACG CCGGTTCTGA CTTTGTAATA 3060
CCCAGTGGAG ATTGGACTGT CAAGTTTGAT AAAACATTCA TGGACAACCT TGAAAGGTAC 3120
AGAAAATACC ATTCATCAAA GTTAATGGAT CTATTAAGAG CACTTAGGAA TAAATATCAT 3180
CATTTTATGG ATTTACCTGA AGATATAGCA GAACTAATGG GGCCGGTACC CGATGGATTT 3240
TACGATTACT TCACCAAGCG TTTTCCAAAC CTATTAATAG GTGTTTATAT GATTGTCAAG 3300
GAAAATTTAA GTGACGATCA AATTTTACGT GAATTTTTGT ATTCATAA 3348
Domain Profile
S: 2     spkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfct  61
         +++++lG+G++Gtvvf+Gsf+gr+vavkr+l++f+d+a +e+kll+esd+hpnviry+c+
Q: 675   VSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCS  734
         799*********************************************************
S: 62    ekdrqfryialelcaaslqdyve.....dkdlelqkelepisllkqiasGlahlhslkiv  116
         e++++f yialelc+++lqd+ve     d++l+lqke++pisll+qiasG+ahlhslki+
Q: 735   ETTDRFLYIALELCNLNLQDLVEsknvsDENLKLQKEYNPISLLRQIASGVAHLHSLKII  794
         ***********************9999999******************************
S: 117   hrdlkpqnilislpd........akgklrvlisdfGlckkldvGkssfsr.rsgvsGteG  167
         hrdlkpqnil+s+++        ++++lr+lisdfGlckkld+G+ssf++  +++sGt+G
Q: 795   HRDLKPQNILVSTSSrftadqqtGAENLRILISDFGLCKKLDSGQSSFRTnLNNPSGTSG  854
         ********************99999************************989********
S: 168   wiapellee............................ltkerltsavdifslGcvfyyvl  199
         w+apellee                            +tk+rlt+++difs+Gcvfyy+l
Q: 855   WRAPELLEEsnnlqcqvetehsssrhtvvssdsfydpFTKRRLTRSIDIFSMGCVFYYIL  914
         ************************************************************
S: 200   skGkhpfGdslkrqanilsgelsldklkeekdeeviae..dliskmidkdplkrpsakkv  257
         skGkhpfGd+++r++ni++g++sld++k+++d+++iae  dlis+mid+dplkrp+a+kv
Q: 915   SKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEatDLISQMIDHDPLKRPTAMKV  974
         ************************************9999********************
S: 258   lkhplf  263
         l+hplf
Q: 975   LRHPLF  980
         *****9
Domain Sequence
(FASTA)
VSEKILGYGS SGTVVFQGSF QGRPVAVKRM LIDFCDIALM EIKLLTESDD HPNVIRYYCS 60
ETTDRFLYIA LELCNLNLQD LVESKNVSDE NLKLQKEYNP ISLLRQIASG VAHLHSLKII 120
HRDLKPQNIL VSTSSRFTAD QQTGAENLRI LISDFGLCKK LDSGQSSFRT NLNNPSGTSG 180
WRAPELLEES NNLQCQVETE HSSSRHTVVS SDSFYDPFTK RRLTRSIDIF SMGCVFYYIL 240
SKGKHPFGDK YSRESNIIRG IFSLDEMKCL HDRSLIAEAT DLISQMIDHD PLKRPTAMKV 300
LRHPLF 306
Keyword3D-structure; ATP-binding; Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Kinase; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00269
EKS-ANC-00278
EKS-BOT-00287
EKS-CAE-00246
EKS-CAJ-00293
EKS-CAF-00293
EKS-CAP-00322
EKS-CII-00169
EKS-CIS-00050
EKS-DAR-00632
EKS-DRM-00146
EKS-ECT-00032
EKS-EQC-00279
EKS-FEC-00273
EKS-GAM-00181
EKS-GAG-00240
EKS-GAA-00355
EKS-GOG-00286
EKS-HOS-00293
EKS-ICT-00272
EKS-LAC-00302
EKS-LOA-00297
EKS-MAM-00290
EKS-MEG-00229
EKS-MIM-00023
EKS-MOD-00282
EKS-MUM-00318
EKS-MUP-00283
EKS-MYL-00289
EKS-NOL-00265
EKS-OCP-00029
EKS-ORN-00373
EKS-ORA-00253
EKS-ORC-00269
EKS-ORL-00345
EKS-OTG-00293
EKS-PAT-00272
EKS-PES-00256
EKS-POA-00279
EKS-RAN-00303
EKS-SAH-00269
EKS-SUS-00253
EKS-TAG-00301
EKS-TAR-00376
EKS-TEN-00371
EKS-TUB-00026
EKS-XET-00360
EKS-XIM-00366
EKS-SCP-00051
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004521; F:endoribonuclease activity
GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0046872; F:metal ion binding
GO:0042803; F:protein homodimerization activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0051082; F:unfolded protein binding
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0031505; P:fungal-type cell wall organization
GO:0006020; P:inositol metabolic process
GO:0006397; P:mRNA processing
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0006351; P:transcription, DNA-dependent
KEGG
sce:YHR079C;
InterPros
IPR010513; KEN_RNase_activator.
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR006567; PUG-dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF06479; Ribonuc_2-5A; 1.
SMARTs
SM00564; PQQ; 3.
SM00580; PUG; 1.
Prosites
PS51392; KEN; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013