EKS-SAC-00092

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00092

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	156.1	4.4E-46	3371	3685	315

Status

Reviewed

Ensembl Protein

YHR099W

UniProt Accession

P38811; D3DL49;

Protein Name

Transcription-associated protein 1

Protein Synonyms/Alias

p400 kDa component of SAGA;

Gene Name

TRA1

Gene Synonyms/Alias

TRA1; YHR099W;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YHR099W	YHR099W	YHR099W

Organism

Saccharomyces cerevisiae

Functional Description

Essential component of histone acetyltransferase (HAT)complexes, which serves as a target for activators during recruitment of HAT complexes. Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.

Protein Length

3744

Protein Sequence
(FASTA)

MSLTEQIEQF ASRFRDDDAT LQSRYSTLSE LYDIMELLNS PEDYHFFLQA VIPLLLNQLK 60

EVPISYDAHS PEQKLRNSML DIFNRCLMNQ TFQPYAMEVL EFLLSVLPKE NEENGILCMK 120

VLTTLFKSFK SILQDKLDSF IRIIIQIYKN TPNLINQTFY EAGKAEQGDL DSPKEPQADE 180

LLDEFSKNDE EKDFPSKQSS TEPRFENSTS SNGLRSSMFS FKILSECPIT MVTLYSSYKQ 240

LTSTSLPEFT PLIMNLLNIQ IKQQQEAREQ AESRGEHFTS ISTEIINRPA YCDFILAQIK 300

ATSFLAYVFI RGYAPEFLQD YVNFVPDLII RLLQDCPSEL SSARKELLHA TRHILSTNYK 360

KLFLPKLDYL FDERILIGNG FTMHETLRPL AYSTVADFIH NIRSELQLSE IEKTIKIYTG 420

YLLDESLALT VQIMSAKLLL NLVERILKLG KENPQEAPRA KKLLMIIIDS YMNRFKTLNR 480

QYDTIMKYYG RYETHKKEKA EKLKNSIQDN DKESEEFMRK VLEPSDDDHL MPQPKKEDIN 540

DSPDVEMTES DKVVKNDVEM FDIKNYAPIL LLPTPTNDPI KDAFYLYRTL MSFLKTIIHD 600

LKVFNPPPNE YTVANPKLWA SVSRVFSYEE VIVFKDLFHE CIIGLKFFKD HNEKLSPETT 660

KKHFDISMPS LPVSATKDAR ELMDYLAFMF MQMDNATFNE IIEQELPFVY ERMLEDSGLL 720

HVAQSFLTSE ITSPNFAGIL LRFLKGKLKD LGNVDFNTSN VLIRLFKLSF MSVNLFPNIN 780

EVVLLPHLND LILNSLKYST TAEEPLVYFY LIRTLFRSIG GGRFENLYRS IKPILQVLLQ 840

SLNQMILTAR LPHERELYVE LCITVPVRLS VLAPYLPFLM KPLVFALQQY PDLVSQGLRT 900

LELCIDNLTA EYFDPIIEPV IDDVSKALFN LLQPQPFNHA ISHNVVRILG KLGGRNRQFL 960

KPPTDLTEKT ELDIDAIADF KINGMPEDVP LSVTPGIQSA LNILQSYKSD IHYRKSAYKY 1020

LTCVLLLMTK SSAEFPTNYT ELLKTAVNSI KLERIGIEKN FDLEPTVNKR DYSNQENLFL 1080

RLLESVFYAT SIKELKDDAM DLLNNLLDHF CLLQVNTTLL NKRNYNGTFN IDLKNPNFML 1140

DSSLILDAIP FALSYYIPEV REVGVLAYKR IYEKSCLIYG EELALSHSFI PELAKQFIHL 1200

CYDETYYNKR GGVLGIKVLI DNVKSSSVFL KKYQYNLANG LLFVLKDTQS EAPSAITDSA 1260

EKLLIDLLSI TFADVKEEDL GNKVLENTLT DIVCELSNAN PKVRNACQKS LHTISNLTGI 1320

PIVKLMDHSK QFLLSPIFAK PLRALPFTMQ IGNVDAITFC LSLPNTFLTF NEELFRLLQE 1380

SIVLADAEDE SLSTNIQKTT EYSTSEQLVQ LRIACIKLLA IALKNEEFAT AQQGNIRIRI 1440

LAVFFKTMLK TSPEIINTTY EALKGSLAEN SKLPKELLQN GLKPLLMNLS DHQKLTVPGL 1500

DALSKLLELL IAYFKVEIGR KLLDHLTAWC RVEVLDTLFG QDLAEQMPTK IIVSIINIFH 1560

LLPPQADMFL NDLLLKVMLL ERKLRLQLDS PFRTPLARYL NRFHNPVTEY FKKNMTLRQL 1620

VLFMCNIVQR PEAKELAEDF EKELDNFYDF YISNIPKNQV RVVSFFTNMV DLFNTMVITN 1680

GDEWLKKKGN MILKLKDMLN LTLKTIKENS FYIDHLQLNQ SIAKFQALYL RFTELSERDQ 1740

NPLLLDFIDF SFSNGIKASY SLKKFIFHNI IASSNKEKQN NFINDATLFV LSDKCLDARI 1800

FVLKNVINST LIYEVATSGS LKSYLVEDKK PKWLELLHNK IWKNSNAILA YDVLDHHDLF 1860

RFELLQLSAI FIKADPEIIA EIKKDIIKFC WNFIKLEDTL IKQSAYLVTS YFISKFDFPI 1920

KVVTQVFVAL LRSSHVEARY LVKQSLDVLT PVLHERMNAA GTPDTWINWV KRVMVENSSS 1980

QNNILYQFLI SHPDLFFNSR DLFISNIIHH MNKITFMSNS NSDSHTLAID LASLILYWEN 2040

KTLEITNVNN TKTDSDGDVV MSDSKSDINP VEADTTAIIV DANNNSPISL HLREACTAFL 2100

IRYVCASNHR AIETELGLRA INILSELISD KHWTNVNVKL VYFEKFLIFQ DLDSENILYY 2160

CMNALDVLYV FFKNKTKEWI MENLPTIQNL LEKCIKSDHH DVQEALQKVL QVIMKAIKAQ 2220

GVSVIIEEES PGKTFIQMLT SVITQDLQET SSVTAGVTLA WVLFMNFPDN IVPLLTPLMK 2280

TFSKLCKDHL SISQPKDAMA LEEARITTKL LEKVLYILSL KVSLLGDSRR PFLSTVALLI 2340

DHSMDQNFLR KIVNMSRSWI FNTEIFPTVK EKAAILTKML AFEIRGEPSL SKLFYEIVLK 2400

LFDQEHFNNT EITVRMEQPF LVGTRVEDIG IRKRFMTILD NSLERDIKER LYYVIRDQNW 2460

EFIADYPWLN QALQLLYGSF NREKELSLKN IYCLSPPSIL QEYLPENAEM VTEVNDLELS 2520

NFVKGHIASM QGLCRIISSD FIDSLIEIFY QDPKAIHRAW VTLFPQVYKS IPKNEKYGFV 2580

RSIITLLSKP YHTRQISSRT NVINMLLDSI SKIESLELPP HLVKYLAISY NAWYQSINIL 2640

ESIQSNTSID NTKIIEANED ALLELYVNLQ EEDMFYGLWR RRAKYTETNI GLSYEQIGLW 2700

DKAQQLYEVA QVKARSGALP YSQSEYALWE DNWIQCAEKL QHWDVLTELA KHEGFTDLLL 2760

ECGWRVADWN SDRDALEQSV KSVMDVPTPR RQMFKTFLAL QNFAESRKGD QEVRKLCDEG 2820

IQLSLIKWVS LPIRYTPAHK WLLHGFQQYM EFLEATQIYA NLHTTTVQNL DSKAQEIKRI 2880

LQAWRDRLPN TWDDVNMWND LVTWRQHAFQ VINNAYLPLI PALQQSNSNS NINTHAYRGY 2940

HEIAWVINRF AHVARKHNMP DVCISQLARI YTLPNIEIQE AFLKLREQAK CHYQNMNELT 3000

TGLDVISNTN LVYFGTVQKA EFFTLKGMFL SKLRAYEEAN QAFATAVQID LNLAKAWAQW 3060

GFFNDRRLSE EPNNISFASN AISCYLQAAG LYKNSKIREL LCRILWLISI DDASGMLTNA 3120

FDSFRGEIPV WYWITFIPQL LTSLSHKEAN MVRHILIRIA KSYPQALHFQ LRTTKEDFAV 3180

IQRQTMAVMG DKPDTNDRNG RRQPWEYLQE LNNILKTAYP LLALSLESLV AQINDRFKST 3240

TDEDLFRLIN VLLIDGTLNY NRLPFPRKNP KLPENTEKNL VKFSTTLLAP YIRPKFNADF 3300

IDNKPDYETY IKRLRYWRRR LENKLDRASK KENLEVLCPH LSNFHHQKFE DIEIPGQYLL 3360

NKDNNVHFIK IARFLPTVDF VRGTHSSYRR LMIRGHDGSV HSFAVQYPAV RHSRREERMF 3420

QLYRLFNKSL SKNVETRRRS IQFNLPIAIP LSPQVRIMND SVSFTTLHEI HNEFCKKKGF 3480

DPDDIQDFMA DKLNAAHDDA LPAPDMTILK VEIFNSIQTM FVPSNVLKDH FTSLFTQFED 3540

FWLFRKQFAS QYSSFVFMSY MMMINNRTPH KIHVDKTSGN VFTLEMLPSR FPYERVKPLL 3600

KNHDLSLPPD SPIFHNNEPV PFRLTPNIQS LIGDSALEGI FAVNLFTISR ALIEPDNELN 3660

TYLALFIRDE IISWFSNLHR PIIENPQLRE MVQTNVDLII RKVAQLGHLN STPTVTTQFI 3720

LDCIGSAVSP RNLARTDVNF MPWF 3744

Nucleotide Sequence
(FASTA)

ATGTCACTCA CTGAGCAGAT CGAGCAATTC GCCAGTAGGT TTCGCGATGA TGATGCCACT 60

CTACAATCGA GATATTCCAC TCTATCGGAA TTGTACGACA TAATGGAATT ACTGAATTCT 120

CCTGAGGATT ACCATTTTTT CTTACAAGCT GTGATACCTT TACTTCTAAA CCAGCTAAAG 180

GAAGTTCCTA TTTCATATGA TGCGCATTCA CCGGAACAAA AGTTGAGAAA CTCTATGCTT 240

GATATTTTCA ACAGGTGTCT CATGAACCAA ACCTTTCAAC CCTACGCAAT GGAAGTGCTC 300

GAGTTTTTAC TTTCAGTACT ACCAAAGGAA AACGAAGAAA ATGGGATATT ATGTATGAAA 360

GTGCTGACGA CACTTTTCAA ATCATTCAAA TCAATACTAC AGGACAAACT CGACTCCTTC 420

ATACGAATAA TTATTCAGAT TTATAAAAAT ACACCAAACC TTATAAACCA GACGTTTTAT 480

GAAGCCGGGA AAGCAGAACA GGGTGATTTG GATTCACCAA AAGAACCACA GGCAGATGAA 540

CTTCTCGATG AATTCTCCAA AAATGATGAA GAAAAGGACT TTCCATCGAA ACAATCATCC 600

ACGGAGCCAA GGTTTGAAAA CTCTACCTCA TCAAACGGGT TGAGGTCATC TATGTTTTCC 660

TTTAAAATCC TTTCTGAATG CCCTATTACA ATGGTCACTT TATATTCGTC TTACAAGCAG 720

TTGACTAGCA CCTCGCTTCC GGAATTCACT CCTCTTATTA TGAATCTATT GAATATACAA 780

ATTAAACAAC AACAGGAAGC GAGAGAACAG GCGGAATCAC GGGGAGAACA TTTCACTTCT 840

ATATCGACGG AGATTATCAA CAGACCGGCT TACTGTGATT TTATATTAGC CCAGATCAAG 900

GCCACGTCTT TCTTGGCTTA CGTATTCATT AGAGGATACG CTCCTGAATT TTTGCAGGAT 960

TATGTGAATT TTGTTCCTGA TTTAATCATA AGGCTTTTAC AAGACTGCCC TTCTGAACTA 1020

TCATCTGCTA GGAAGGAACT TTTGCATGCC ACTAGACACA TTCTATCTAC AAACTACAAA 1080

AAGCTCTTTT TACCCAAATT GGACTATCTG TTTGACGAAC GTATACTTAT TGGTAACGGT 1140

TTTACTATGC ATGAAACATT AAGGCCCCTG GCTTATAGTA CTGTGGCAGA TTTCATTCAT 1200

AATATAAGAT CTGAATTACA ACTAAGTGAA ATTGAAAAAA CAATAAAGAT TTACACTGGA 1260

TATCTATTGG ATGAGTCATT AGCCTTAACT GTACAAATCA TGAGTGCAAA ATTGCTGCTT 1320

AATTTAGTTG AAAGAATATT AAAATTGGGA AAGGAGAACC CACAAGAGGC CCCTAGAGCA 1380

AAGAAATTGT TAATGATAAT CATTGACTCA TATATGAATA GATTTAAAAC CTTAAACAGA 1440

CAGTACGATA CAATAATGAA GTACTATGGA AGATACGAAA CGCATAAGAA GGAGAAAGCA 1500

GAAAAGCTCA AAAACTCTAT ACAGGATAAT GACAAAGAGA GTGAGGAATT TATGAGGAAG 1560

GTACTGGAAC CATCCGATGA CGACCATTTG ATGCCACAGC CTAAAAAAGA AGATATCAAT 1620

GATAGTCCCG ATGTTGAAAT GACAGAATCT GACAAAGTGG TGAAGAATGA CGTTGAAATG 1680

TTTGACATAA AAAACTACGC ACCTATATTA TTACTACCCA CACCAACAAA TGATCCCATC 1740

AAGGATGCTT TTTACTTATA CAGAACTTTA ATGTCTTTCT TAAAAACAAT AATTCATGAC 1800

TTAAAAGTCT TTAACCCACC TCCTAACGAA TATACGGTTG CTAATCCTAA ATTGTGGGCT 1860

TCTGTTTCTA GAGTTTTTTC ATATGAGGAA GTCATTGTTT TCAAGGATTT ATTTCACGAA 1920

TGTATTATTG GTTTGAAATT TTTTAAAGAT CATAATGAAA AATTATCTCC AGAAACAACA 1980

AAAAAACATT TTGATATATC AATGCCCAGC CTACCGGTCT CAGCCACCAA AGATGCTCGT 2040

GAGTTAATGG ACTATTTGGC ATTTATGTTT ATGCAGATGG ATAATGCCAC TTTTAATGAA 2100

ATAATTGAAC AGGAACTGCC ATTTGTCTAT GAAAGAATGC TGGAGGATTC TGGGCTGCTA 2160

CATGTCGCGC AATCCTTTTT AACAAGTGAA ATAACCTCCC CAAATTTTGC TGGCATCCTT 2220

TTAAGATTCT TGAAAGGGAA ATTGAAAGAT TTAGGAAACG TTGATTTTAA CACTTCTAAT 2280

GTCCTAATAC GACTTTTCAA ATTGTCCTTT ATGTCCGTCA ATCTTTTCCC CAATATCAAT 2340

GAGGTTGTTC TTCTTCCACA CTTAAACGAT CTAATTCTAA ACTCCCTGAA ATACTCAACT 2400

ACAGCAGAAG AGCCTCTAGT ATACTTTTAT CTTATTAGAA CTCTTTTTAG AAGTATAGGT 2460

GGGGGCAGAT TTGAAAACTT ATATAGATCG ATTAAGCCCA TACTACAGGT GCTATTACAA 2520

TCTTTAAACC AAATGATACT TACTGCACGA TTGCCCCACG AGAGAGAACT TTATGTGGAA 2580

TTATGCATCA CTGTACCAGT TCGGTTAAGT GTGCTTGCTC CTTATTTGCC ATTTTTGATG 2640

AAACCATTGG TATTTGCATT ACAGCAATAT CCTGATCTCG TTTCGCAGGG TTTAAGGACC 2700

TTAGAATTAT GTATTGATAA TTTGACCGCC GAGTATTTTG ATCCTATAAT CGAACCGGTA 2760

ATCGATGACG TTTCGAAGGC CTTGTTTAAC CTTCTGCAAC CTCAACCATT TAATCATGCT 2820

ATCAGCCACA ACGTAGTCAG AATACTGGGC AAATTAGGAG GTAGAAATCG TCAATTTTTA 2880

AAGCCACCAA CGGACCTCAC GGAAAAAACG GAACTAGACA TTGATGCGAT AGCAGATTTC 2940

AAAATCAATG GTATGCCGGA AGATGTACCG CTTTCTGTAA CGCCAGGAAT CCAGTCCGCT 3000

TTGAATATAT TGCAAAGCTA CAAAAGTGAT ATTCACTACA GGAAGAGTGC TTACAAGTAT 3060

CTAACCTGTG TACTACTGTT AATGACAAAA TCATCAGCAG AGTTTCCTAC GAATTACACG 3120

GAACTGTTGA AGACAGCAGT GAATTCTATA AAGCTAGAGA GGATTGGAAT AGAAAAAAAC 3180

TTTGATTTGG AACCAACTGT AAATAAGAGA GATTATTCGA ACCAAGAAAA TTTGTTTTTG 3240

AGGTTACTGG AGAGCGTTTT TTACGCAACT TCGATAAAGG AACTAAAAGA TGACGCAATG 3300

GACCTACTGA ATAACCTTTT GGATCATTTC TGCCTATTAC AAGTAAACAC TACGTTGCTT 3360

AATAAGAGAA ACTATAATGG GACATTTAAC ATCGATCTAA AGAACCCAAA CTTCATGCTA 3420

GATAGCTCAT TGATTCTAGA TGCTATTCCC TTTGCCCTTT CGTACTACAT TCCAGAAGTT 3480

CGTGAGGTGG GTGTTTTGGC GTACAAAAGA ATATACGAAA AAAGTTGTCT GATATATGGG 3540

GAGGAACTAG CTTTAAGTCA CTCCTTCATA CCGGAATTAG CTAAACAGTT TATCCATTTG 3600

TGTTACGACG AAACATATTA CAACAAAAGA GGCGGTGTCT TGGGTATAAA AGTTCTCATT 3660

GATAATGTTA AGTCGTCCTC AGTTTTCCTA AAAAAGTATC AGTATAACCT AGCCAATGGT 3720

CTATTATTTG TGCTGAAGGA CACTCAGAGC GAGGCCCCAT CTGCTATAAC AGATAGCGCT 3780

GAGAAATTAC TAATAGATCT ATTAAGTATT ACGTTCGCGG ATGTAAAAGA AGAGGATTTG 3840

GGTAACAAAG TCTTGGAGAA CACACTGACG GACATAGTAT GCGAATTAAG TAATGCAAAT 3900

CCTAAGGTAA GAAATGCCTG CCAGAAGTCC TTACATACAA TTTCAAACCT CACTGGAATT 3960

CCTATAGTAA AATTGATGGA TCATTCCAAA CAATTTCTTC TATCACCAAT ATTTGCAAAA 4020

CCTTTAAGAG CATTACCTTT CACTATGCAA ATCGGTAATG TCGATGCTAT CACATTCTGT 4080

TTAAGTCTAC CAAACACATT TCTAACATTT AATGAAGAAC TGTTTAGGTT ACTCCAAGAA 4140

TCTATTGTCT TGGCAGATGC AGAAGATGAA TCACTATCCA CCAATATCCA AAAGACAACC 4200

GAATATAGTA CTTCCGAGCA ATTAGTACAA TTAAGAATAG CGTGCATAAA ATTACTTGCG 4260

ATTGCTCTTA AAAATGAAGA ATTTGCCACA GCTCAACAAG GAAACATCAG AATTCGAATT 4320

CTAGCTGTTT TTTTCAAAAC AATGCTGAAA ACTTCACCAG AAATTATTAA TACTACATAT 4380

GAAGCTTTGA AAGGTTCCTT AGCAGAAAAC TCTAAATTGC CGAAAGAATT ACTTCAGAAC 4440

GGATTAAAAC CTCTTTTAAT GAATTTATCT GACCACCAAA AGCTGACGGT CCCTGGTCTG 4500

GATGCTTTAT CGAAGCTTCT CGAGTTATTG ATTGCATACT TTAAAGTAGA AATCGGAAGA 4560

AAGTTGTTAG ATCACCTCAC GGCATGGTGC CGTGTTGAAG TTCTTGACAC ATTATTTGGC 4620

CAAGATTTAG CAGAGCAGAT GCCAACTAAA ATAATAGTAA GCATTATTAA TATATTTCAT 4680

CTACTGCCAC CACAAGCTGA TATGTTTTTA AATGATTTGT TGCTCAAAGT TATGCTTCTA 4740

GAGAGAAAAC TACGTCTTCA ACTGGATTCT CCATTTCGTA CACCACTAGC GAGGTACCTG 4800

AACCGTTTCC ATAACCCCGT AACAGAGTAC TTCAAGAAAA ATATGACGTT AAGGCAATTA 4860

GTGCTTTTCA TGTGCAATAT TGTGCAAAGA CCTGAAGCAA AGGAGCTGGC CGAAGATTTT 4920

GAGAAAGAAC TCGACAACTT CTATGACTTT TACATTTCCA ATATACCAAA AAACCAAGTA 4980

CGTGTTGTTA GTTTTTTTAC TAATATGGTT GATCTCTTTA ATACAATGGT GATCACGAAT 5040

GGGGACGAAT GGCTAAAGAA AAAAGGCAAC ATGATTTTGA AATTAAAAGA TATGCTGAAC 5100

TTGACATTAA AAACAATAAA GGAAAACTCG TTTTACATCG ACCATCTACA ATTAAATCAA 5160

AGTATTGCAA AATTCCAAGC TCTTTACCTG CGTTTCACTG AATTATCCGA AAGGGATCAA 5220

AATCCTCTGC TCCTAGATTT CATTGATTTT TCTTTTTCAA ATGGTATCAA AGCCTCATAT 5280

TCCCTCAAGA AATTCATCTT CCATAATATA ATAGCAAGTT CAAATAAAGA AAAGCAGAAT 5340

AACTTCATAA ATGATGCAAC ACTTTTCGTT CTATCTGACA AATGTTTGGA TGCTAGAATA 5400

TTTGTACTTA AAAATGTCAT AAATTCAACT TTGATTTATG AAGTGGCAAC ATCTGGATCT 5460

TTGAAAAGCT ATCTTGTGGA GGATAAAAAA CCTAAATGGT TAGAGTTACT CCACAATAAA 5520

ATTTGGAAGA ACTCAAATGC AATTTTAGCA TATGACGTTC TAGACCATCA TGATTTATTC 5580

CGTTTTGAAC TCTTACAACT GTCAGCAATT TTCATTAAGG CAGATCCAGA AATTATAGCC 5640

GAGATAAAGA AAGATATAAT AAAATTCTGC TGGAATTTCA TAAAGCTCGA AGATACCCTT 5700

ATCAAACAAT CCGCGTACCT GGTTACATCA TATTTCATAT CCAAGTTTGA TTTCCCTATT 5760

AAAGTTGTCA CCCAGGTTTT TGTTGCCCTA TTACGTTCTT CTCATGTCGA AGCTAGGTAC 5820

TTAGTTAAGC AATCGCTGGA CGTTCTCACC CCTGTTCTCC ATGAACGTAT GAACGCAGCT 5880

GGGACGCCCG ATACCTGGAT TAACTGGGTT AAAAGGGTAA TGGTAGAAAA TTCTTCTAGT 5940

CAGAACAACA TTTTATACCA ATTTTTGATA AGCCACCCTG ATTTATTTTT CAATTCAAGA 6000

GATTTGTTCA TATCAAATAT TATTCATCAT ATGAATAAGA TAACGTTCAT GTCAAATTCA 6060

AACTCTGATA GTCATACTTT AGCTATTGAT TTGGCGTCAT TAATTCTTTA TTGGGAGAAC 6120

AAGACCTTAG AAATTACGAA TGTAAATAAT ACCAAGACCG ATTCCGACGG AGATGTTGTA 6180

ATGTCCGATT CTAAAAGTGA TATTAATCCA GTTGAGGCTG ACACAACCGC AATAATTGTA 6240

GACGCTAATA ACAACTCGCC TATATCTTTA CATTTACGCG AGGCTTGTAC GGCGTTTTTG 6300

ATAAGATACG TGTGTGCAAG TAATCACCGT GCCATAGAAA CAGAACTAGG ATTAAGAGCT 6360

ATCAATATTT TATCAGAATT AATCTCAGAT AAGCATTGGA CAAACGTCAA TGTTAAACTG 6420

GTTTACTTCG AGAAGTTTTT GATATTTCAA GATCTCGATT CCGAAAATAT TCTTTACTAC 6480

TGCATGAATG CTTTGGATGT GCTTTATGTA TTCTTCAAAA ATAAGACAAA AGAATGGATA 6540

ATGGAAAACT TACCTACCAT TCAAAATCTT CTAGAAAAAT GTATCAAATC TGATCATCAC 6600

GATGTACAGG AAGCTCTGCA AAAAGTTTTG CAGGTAATAA TGAAGGCAAT AAAAGCTCAG 6660

GGTGTATCAG TGATAATTGA AGAAGAAAGC CCTGGTAAGA CATTTATCCA AATGTTAACC 6720

TCCGTGATAA CTCAGGATCT TCAGGAAACC TCATCAGTTA CAGCTGGTGT AACTCTAGCT 6780

TGGGTACTCT TCATGAACTT TCCGGATAAC ATCGTCCCAT TATTAACGCC TTTGATGAAG 6840

ACGTTCAGTA AGTTATGCAA AGATCACTTA AGCATTTCAC AACCGAAGGA CGCCATGGCT 6900

CTGGAAGAGG CAAGGATTAC GACGAAACTT TTAGAGAAAG TTTTATATAT ATTATCTTTG 6960

AAAGTCTCAC TCTTGGGTGA CTCCCGTCGT CCTTTCCTCT CCACTGTGGC ACTTCTGATT 7020

GATCACTCCA TGGATCAAAA TTTTTTGAGG AAAATTGTCA ATATGTCCAG AAGCTGGATA 7080

TTCAATACTG AAATTTTTCC AACTGTTAAA GAAAAAGCGG CTATATTAAC GAAGATGCTG 7140

GCGTTTGAGA TTAGAGGGGA ACCTTCATTG TCAAAGCTAT TCTACGAAAT AGTCTTGAAA 7200

CTATTTGATC AAGAACATTT TAATAACACA GAAATTACCG TTAGAATGGA ACAACCTTTC 7260

CTCGTAGGAA CGCGTGTTGA AGACATCGGT ATAAGGAAAA GATTCATGAC AATTTTGGAT 7320

AATAGTTTGG AAAGAGATAT CAAAGAGAGA CTATATTATG TTATACGGGA CCAAAACTGG 7380

GAATTTATTG CTGATTATCC ATGGTTAAAT CAAGCTTTAC AATTACTATA TGGTTCTTTT 7440

AATAGAGAGA AGGAATTATC TTTAAAGAAC ATTTATTGTT TGTCTCCACC ATCGATTTTA 7500

CAAGAGTACC TCCCAGAAAA TGCTGAAATG GTAACCGAAG TAAACGATCT GGAATTATCA 7560

AACTTTGTTA AAGGTCATAT AGCTTCCATG CAAGGTTTAT GTCGAATAAT CTCTTCGGAT 7620

TTCATCGATT CTTTGATTGA AATATTTTAC CAAGATCCAA AAGCAATTCA TAGAGCGTGG 7680

GTTACGTTAT TTCCCCAGGT ATACAAAAGT ATTCCAAAGA ATGAAAAATA CGGGTTTGTT 7740

CGATCTATCA TTACATTGCT TTCTAAACCT TATCATACCA GACAAATTTC CTCTAGGACA 7800

AATGTGATTA ATATGCTATT GGACTCAATA AGTAAAATTG AATCGTTAGA ATTACCCCCT 7860

CATTTGGTCA AATACTTGGC GATATCATAC AACGCTTGGT ATCAATCGAT TAACATCTTG 7920

GAATCCATTC AAAGCAATAC TAGCATCGAC AATACAAAAA TTATCGAAGC CAACGAAGAT 7980

GCGCTATTAG AACTATACGT CAATCTACAA GAAGAAGACA TGTTTTATGG TCTTTGGAGA 8040

CGTAGAGCAA AATACACAGA GACTAACATT GGTTTATCAT ATGAACAAAT TGGCCTTTGG 8100

GACAAAGCTC AACAACTTTA TGAAGTGGCA CAGGTCAAAG CTCGTAGTGG TGCCTTGCCC 8160

TACTCACAGT CTGAGTATGC ACTATGGGAA GATAACTGGA TACAGTGTGC TGAAAAATTA 8220

CAACATTGGG ACGTATTAAC TGAATTAGCG AAGCATGAAG GGTTCACGGA CTTATTATTA 8280

GAATGTGGTT GGCGTGTTGC TGATTGGAAC AGTGATCGTG ATGCACTTGA GCAATCAGTA 8340

AAAAGCGTTA TGGACGTTCC AACTCCACGA AGGCAAATGT TTAAGACCTT TTTGGCTCTT 8400

CAAAATTTCG CAGAAAGCAG AAAAGGAGAT CAAGAAGTTA GAAAGCTATG CGATGAAGGA 8460

ATACAATTAA GTCTAATAAA GTGGGTGTCT CTGCCAATTA GATATACACC AGCTCATAAG 8520

TGGCTATTAC ATGGGTTTCA ACAGTACATG GAATTTTTGG AAGCGACACA GATATATGCT 8580

AACTTGCATA CAACAACAGT ACAGAATCTG GATTCTAAAG CCCAAGAGAT TAAGCGCATC 8640

TTGCAAGCTT GGAGAGACCG TCTACCAAAC ACATGGGATG ATGTCAATAT GTGGAATGAC 8700

CTAGTAACAT GGAGACAACA TGCATTCCAG GTTATTAACA ACGCATATCT CCCATTAATA 8760

CCGGCACTTC AACAATCAAA CAGTAATAGC AATATTAATA CTCATGCATA TAGGGGATAT 8820

CATGAAATTG CCTGGGTAAT CAACAGGTTT GCACATGTTG CAAGGAAGCA CAACATGCCT 8880

GACGTGTGTA TCAGTCAGCT GGCACGTATT TACACCCTAC CGAATATAGA AATTCAGGAG 8940

GCTTTCCTAA AGTTAAGGGA GCAAGCTAAA TGTCATTACC AAAACATGAA CGAATTAACA 9000

ACGGGTCTGG ATGTTATTAG TAATACTAAT TTGGTTTACT TTGGTACTGT CCAAAAAGCT 9060

GAATTCTTCA CATTGAAGGG TATGTTTTTG TCTAAATTAC GCGCATATGA AGAGGCAAAT 9120

CAAGCCTTTG CAACAGCTGT TCAGATAGAC TTGAACTTGG CTAAAGCATG GGCCCAATGG 9180

GGTTTCTTCA ATGACCGTCG TTTGTCAGAA GAGCCAAACA ACATTAGTTT TGCTAGTAAT 9240

GCAATAAGCT GTTATTTACA AGCCGCCGGC CTGTATAAGA ACTCGAAGAT TAGGGAGTTA 9300

TTGTGCAGGA TTTTATGGCT CATCAGTATA GATGATGCTT CGGGCATGCT CACAAACGCA 9360

TTTGACTCCT TTAGAGGCGA AATACCCGTT TGGTACTGGA TTACTTTCAT TCCTCAACTA 9420

TTAACCTCTC TATCACATAA GGAGGCCAAT ATGGTTCGTC ATATCTTAAT CAGAATTGCT 9480

AAAAGTTATC CTCAAGCTCT TCACTTCCAA TTAAGAACGA CAAAGGAAGA TTTCGCCGTT 9540

ATCCAACGAC AGACAATGGC TGTTATGGGG GATAAACCAG ATACAAACGA TCGGAATGGA 9600

CGGCGCCAGC CTTGGGAATA TTTACAAGAG TTAAACAATA TTCTAAAGAC AGCTTATCCA 9660

TTGTTGGCCT TATCCTTAGA GTCTCTTGTT GCCCAAATAA ACGACCGTTT CAAATCTACT 9720

ACTGACGAAG ATCTTTTCAG GTTGATAAAT GTCCTATTGA TCGATGGAAC GCTGAACTAC 9780

AATCGCTTAC CATTTCCTAG GAAAAATCCA AAACTTCCTG AAAATACAGA AAAAAATTTG 9840

GTCAAATTTT CTACAACTTT GTTGGCGCCT TATATAAGAC CAAAGTTCAA TGCCGACTTT 9900

ATTGACAATA AACCGGATTA CGAAACTTAT ATCAAGAGAT TACGTTACTG GCGAAGGAGG 9960

TTGGAAAACA AGCTTGATAG AGCATCAAAA AAAGAAAATC TAGAAGTATT ATGTCCACAT 10020

TTAAGCAACT TCCATCACCA AAAATTCGAG GATATTGAAA TTCCTGGCCA GTATCTTTTG 10080

AACAAGGATA ATAATGTTCA CTTTATTAAA ATTGCCAGAT TTTTACCCAC GGTCGATTTT 10140

GTTCGCGGAA CACATTCTTC ATATAGGCGT TTAATGATTC GGGGCCATGA TGGCAGTGTA 10200

CATTCATTTG CTGTTCAATA TCCAGCTGTT CGCCATTCAA GAAGAGAAGA AAGGATGTTT 10260

CAATTGTACA GATTATTCAA CAAGTCATTA TCCAAGAATG TGGAAACAAG ACGTCGCAGT 10320

ATACAGTTCA ATCTACCAAT AGCAATCCCG CTATCTCCAC AAGTCCGTAT CATGAATGAT 10380

AGTGTTTCTT TTACTACCCT TCATGAAATT CACAATGAAT TTTGCAAGAA AAAAGGATTT 10440

GACCCGGATG ATATCCAAGA TTTTATGGCA GATAAACTAA ACGCAGCGCA TGATGATGCT 10500

CTGCCTGCGC CAGATATGAC CATATTGAAA GTTGAAATTT TCAATTCAAT TCAAACAATG 10560

TTTGTACCAT CAAATGTTTT AAAAGACCAT TTTACCTCGT TGTTTACTCA ATTTGAAGAT 10620

TTCTGGTTAT TCCGTAAACA ATTTGCGTCA CAATACAGTT CGTTTGTCTT CATGTCTTAC 10680

ATGATGATGA TCAATAACCG TACTCCTCAC AAAATCCATG TTGACAAAAC CTCTGGTAAT 10740

GTATTTACTT TAGAAATGTT ACCCTCAAGA TTTCCATATG AAAGGGTGAA ACCATTGCTA 10800

AAGAATCATG ACTTAAGTCT TCCACCAGAT TCTCCGATAT TTCATAATAA TGAACCAGTT 10860

CCATTCAGAC TGACGCCTAA TATTCAATCT TTGATAGGTG ATTCTGCTTT AGAAGGTATA 10920

TTTGCGGTAA ATTTATTTAC CATATCACGT GCATTAATTG AACCTGATAA TGAACTGAAC 10980

ACATACTTGG CCCTATTCAT CCGTGACGAG ATCATATCAT GGTTTAGCAA CCTTCACCGG 11040

CCAATCATTG AAAATCCACA GTTACGTGAG ATGGTTCAAA CCAACGTTGA CCTAATTATT 11100

AGAAAGGTGG CACAATTGGG CCATTTGAAT TCAACACCTA CAGTCACAAC CCAGTTCATC 11160

CTAGACTGTA TTGGCAGCGC TGTCAGTCCA AGAAACTTAG CAAGAACAGA CGTGAACTTC 11220

ATGCCATGGT TCTAG 11235

Domain Profile

S: 1     iagfderveila.skqkpkklllrGsdgkeypyLv..kgkeDlrqdervlqlfslvNtlL  57

         ia+f ++v+ +  ++   ++l++rG+dg  + + v   +   +r++er+ ql +l N+ L

Q: 3371  IARFLPTVDFVRgTHSSYRRLMIRGHDGSVHSFAVqyPAVRHSRREERMFQLYRLFNKSL  3430

         799999999887256899*****************877899*******************

S: 58    akdketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyry  117

          k+ et+rr +++  +  +pls++++++++  + ++L+e+ ++ ++kk+ + d+ +

Q: 3431  SKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIHNEFCKKKGFDPDDIQDFMA  3490

         ****************************************************97776666

S: 118   kdlstvqar.kpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytr  176

         ++l++      p+ + + l++e+f+ ++  +vp ++lk  + + f++ e+++ +rk++++

Q: 3491  DKLNAAHDDaLPAPDMTILKVEIFNSIQTMFVPSNVLKDHFTSLFTQFEDFWLFRKQFAS  3550

         66665554427888999999****************************************

S: 177   slAvislvgyiLgLgdrhlenllidqetgevvhidf...............gv..afeka  219

         +     ++ y++ +++r +  + +d+++g+v   +                ++   +  +

Q: 3551  QYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEMlpsrfpyervkpllkNHdlSLPPD  3610

         *****************************9988764333112222211111110012223

S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279

            ++ +e+vPFRLT+ni+ ++g   +eG+f+  + ++ r+l+e+ ++l t L  f++d+

Q: 3611  SPIFHNNEPVPFRLTPNIQSLIGDSALEGIFAVNLFTISRALIEPDNELNTYLALFIRDE  3670

         3336789*****************************************************

S: 280   lvdwkkkkktskete  294

         ++ w  + +   +++

Q: 3671  IISWFSNLHRPIIEN  3685

         ****87444443444

Domain Sequence
(FASTA)

IARFLPTVDF VRGTHSSYRR LMIRGHDGSV HSFAVQYPAV RHSRREERMF QLYRLFNKSL 60

SKNVETRRRS IQFNLPIAIP LSPQVRIMND SVSFTTLHEI HNEFCKKKGF DPDDIQDFMA 120

DKLNAAHDDA LPAPDMTILK VEIFNSIQTM FVPSNVLKDH FTSLFTQFED FWLFRKQFAS 180

QYSSFVFMSY MMMINNRTPH KIHVDKTSGN VFTLEMLPSR FPYERVKPLL KNHDLSLPPD 240

SPIFHNNEPV PFRLTPNIQS LIGDSALEGI FAVNLFTISR ALIEPDNELN TYLALFIRDE 300

IISWFSNLHR PIIEN 315

Keyword

Activator; Chromatin regulator; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0070209	; C:ASTRA complex
GO:0035267	; C:NuA4 histone acetyltransferase complex
GO:0000124	; C:SAGA complex
GO:0046695	; C:SLIK (SAGA-like) complex
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor
GO:0006281	; P:DNA repair
GO:0016573	; P:histone acetylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351	; P:transcription, DNA-dependent

KEGG

sce:YHR099W

;

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; FALSE_NEG.
PS50290	; PI3_4_KINASE_3; FALSE_NEG.
PS50005	; TPR; FALSE_NEG.
PS50293	; TPR_REGION; FALSE_NEG.

Prints

Created Date

20-Feb-2013