EKS-SAC-00079

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00079

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	307.9	1.8E-92	23	276	254

Status

Reviewed

Ensembl Protein

YHR102W

UniProt Accession

P38692; D3DL52;

Protein Name

Serine/threonine-protein kinase KIC1

Protein Synonyms/Alias

Kinase that interacts with CDC31; N-rich kinase 1;

Gene Name

KIC1

Gene Synonyms/Alias

KIC1; NRK1; YHR102W;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YHR102W	YHR102W	YHR102W

Organism

Saccharomyces cerevisiae

Functional Description

Protein kinase involved in morphogenesis and cellintegrity.

Protein Length

1080

Protein Sequence
(FASTA)

MTTKPQNSKQ GLAEGEMDVS SLFKRTEVIG RGKFGVVYKG YNVKTGRVYA IKVLNLDSDS 60

DEVEDVQREI QFLASLKQIS NITRYYGSYL KDTSLWIIME HCAGGSLRSL LRPGKIDEKY 120

IGVIMRELLV ALKCIHKDNV IHRDIKAANV LITNEGNVKL CDFGVAAQVN QTSLRRQTMA 180

GTPYWMAPEV IMEGVYYDTK VDIWSLGITT YEIATGNPPY CDVEALRAMQ LIIKSKPPRL 240

EDRSYSTSLK EFIALCLDED PKERLSADDL LKSKFIRAHK ATPTSILKEL ISRYLLFRDK 300

NKNKYKIEGS IPENEPSKPS EAPKPSQNGG GDEAQKSIAS NDNEIKRVNE GDVEMKWDFD 360

SLSSSDYIIE NNINLDALAE DNNEWATAQH DLFNYAYPDE DSYYFDPTSH NTRPFVYQGT 420

TIGKGYPGTI AQNSTLNAPV TNNYTNSKYP SKMVAGTTNT SGTHTAGPMT SSKRLESKAP 480

KQLLELFEDN EIITAENDVN TEAPKISKSI SSLNAGNSSR DDFIPSISNE VNGNINNNKM 540

RPHLPPLSSG NNYYSQSTPA LPLLQTKFNK TSKGPPTSGL TTAPTSIEIE IPEELPNSAL 600

PTPASADPVL IPSTKARSST VTAGTPSSSS SIQYKSPSNV PRRLTVSNNR PEHCPSTITN 660

QKLGSAVASN SGISSTPNNS NNYNNNTDSE NSRGSSGSNT ANSTQMGITN PGNVTKLSTH 720

KASSPSRPLF GVGTSPNRKP AGSPTQNIGH NSTHTNLAPP PTMKPMANSK DNKDILLQPL 780

NSIPSSSTLN TISGNSSNNL TSSNYFSNEK EGSRVNGDFK RNNPNLKLQM PLPTPVVRNK 840

LLDPNTATSQ NNNGMPGSAG ISTNENINQF GFNTSSASNI PVSMTPISEK HIDFGGKIKR 900

SQSISNRKNS SASEHPLNIL GSSVSGNVSG IGNNNVGSNN NSGPNNSVPL SANTGNTTIK 960

ANSTTIATSS SAAASTTAPI SQQTIPSGTQ FNHILSSAAT AANSVNSLGF GMCPPPQSLQ 1020

MEMFLDLESF LPGKQRRVDR KPQVLKELEN LLQMFEEGLP CIEHALKEQL ISTPIKDNEH 1080

Nucleotide Sequence
(FASTA)

ATGACGACGA AGCCACAAAA TAGTAAGCAG GGTTTAGCCG AAGGAGAGAT GGATGTGAGT 60

TCACTTTTCA AGAGAACGGA AGTTATTGGG CGAGGGAAAT TTGGTGTGGT TTATAAGGGC 120

TATAACGTGA AGACTGGACG AGTGTATGCT ATCAAAGTCT TAAATTTAGA TTCTGATTCT 180

GACGAGGTGG AGGATGTGCA GCGAGAAATT CAGTTTTTGG CCTCCTTGAA ACAGATTTCC 240

AATATCACGC GGTATTATGG GTCGTATTTG AAAGACACAA GCCTTTGGAT CATAATGGAA 300

CACTGCGCTG GTGGTTCACT GCGTTCGTTG TTAAGGCCAG GCAAAATCGA TGAAAAGTAC 360

ATTGGGGTTA TTATGAGAGA ACTGCTTGTA GCATTAAAAT GCATTCATAA AGATAACGTC 420

ATTCATCGAG ATATCAAAGC AGCAAACGTT CTGATCACTA ACGAAGGTAA TGTTAAACTA 480

TGCGATTTTG GTGTCGCTGC ACAAGTAAAC CAAACTTCTT TACGACGTCA AACTATGGCT 540

GGGACCCCCT ACTGGATGGC TCCAGAAGTG ATCATGGAAG GCGTTTATTA CGACACTAAA 600

GTAGATATAT GGTCTTTAGG TATTACAACG TACGAGATTG CCACCGGAAA TCCGCCATAC 660

TGCGATGTGG AGGCCCTAAG GGCAATGCAA CTAATCATCA AATCGAAACC ACCGAGGCTT 720

GAGGACAGAT CATACAGTAC ATCTTTGAAA GAATTTATTG CGCTTTGTCT TGATGAGGAT 780

CCAAAGGAGA GATTGTCAGC AGACGATCTT TTAAAATCAA AATTTATCAG GGCCCACAAG 840

GCGACGCCAA CGTCCATTTT GAAAGAACTA ATATCACGAT ATCTACTATT TAGGGACAAG 900

AATAAAAACA AATATAAAAT AGAGGGCAGT ATACCGGAAA ATGAGCCATC AAAACCCAGT 960

GAAGCTCCAA AACCATCACA AAATGGCGGG GGTGATGAAG CACAAAAGTC AATAGCATCA 1020

AATGATAATG AAATTAAGAG AGTGAACGAA GGCGATGTGG AAATGAAATG GGATTTTGAT 1080

TCATTGAGTT CGTCGGATTA TATTATTGAA AATAATATCA ACCTCGATGC TTTGGCTGAG 1140

GACAACAACG AGTGGGCTAC TGCCCAACAT GACCTGTTCA ACTATGCATA CCCTGACGAA 1200

GATTCTTATT ACTTTGACCC TACAAGTCAT AATACTAGAC CCTTTGTTTA TCAAGGGACA 1260

ACGATAGGAA AGGGCTATCC TGGTACAATA GCTCAAAATT CTACTTTGAA TGCACCAGTA 1320

ACAAATAACT ATACGAACTC AAAATACCCT TCCAAAATGG TAGCTGGAAC TACAAACACC 1380

TCTGGAACAC ATACGGCCGG TCCAATGACA TCATCTAAGA GGCTGGAAAG TAAGGCTCCA 1440

AAACAATTAC TTGAACTTTT TGAAGACAAT GAAATTATTA CTGCTGAAAA TGATGTCAAT 1500

ACAGAAGCTC CTAAAATAAG CAAATCCATT TCATCTCTAA ATGCTGGTAA TAGTTCACGA 1560

GATGATTTCA TTCCCTCAAT ATCCAACGAG GTCAACGGAA ATATCAATAA TAATAAAATG 1620

CGACCACACC TTCCACCTTT ATCCAGTGGG AACAATTATT ATAGCCAGAG TACACCTGCT 1680

TTGCCGCTAC TCCAAACAAA ATTTAACAAG ACGTCAAAGG GCCCTCCAAC AAGTGGATTA 1740

ACTACTGCTC CAACGTCTAT TGAAATAGAA ATTCCTGAAG AACTACCGAA TAGTGCTCTA 1800

CCAACGCCTG CGAGCGCAGA TCCGGTTTTA ATACCAAGCA CAAAGGCCAG GTCATCTACA 1860

GTGACGGCTG GCACTCCTTC GTCATCTAGC TCAATACAAT ATAAATCACC TTCAAACGTG 1920

CCCAGGCGGT TGACAGTCAG TAACAATAGG CCAGAACATT GCCCAAGCAC CATAACAAAT 1980

CAAAAATTGG GGTCCGCAGT TGCTTCTAAT TCCGGAATCA GCTCCACTCC GAACAACAGT 2040

AATAACTATA ACAACAACAC TGATAGTGAG AACTCAAGAG GAAGCAGCGG TAGTAACACT 2100

GCAAATAGCA CACAAATGGG CATAACCAAT CCAGGTAATG TAACAAAGTT ATCTACTCAT 2160

AAGGCTTCTT CACCCTCAAG GCCACTATTT GGAGTTGGAA CTTCTCCCAA TAGAAAGCCT 2220

GCCGGTTCCC CAACCCAAAA CATTGGTCAT AATTCTACTC ACACGAACCT CGCGCCTCCT 2280

CCTACGATGA AACCAATGGC CAATAGCAAA GATAACAAGG ACATTCTCTT GCAACCTCTG 2340

AACAGCATAC CTAGTTCTTC TACACTTAAC ACTATTAGTG GTAATAGCAG CAATAATTTA 2400

ACCTCATCAA ACTACTTTTC CAACGAAAAG GAAGGCTCAA GGGTCAATGG TGACTTTAAA 2460

CGCAACAACC CAAACTTAAA ACTACAAATG CCACTACCTA CACCTGTTGT GAGAAATAAA 2520

CTTCTTGATC CAAATACAGC AACCTCACAG AATAACAATG GCATGCCGGG GAGCGCTGGC 2580

ATATCCACGA ACGAAAATAT TAATCAATTT GGATTTAACA CAAGCAGTGC GTCCAACATC 2640

CCTGTCTCAA TGACTCCAAT TAGTGAGAAA CACATTGATT TTGGGGGCAA GATCAAGAGA 2700

AGTCAAAGCA TTTCTAACAG GAAGAACTCT TCTGCCTCGG AACACCCATT GAATATTCTT 2760

GGCTCATCTG TTTCCGGCAA TGTTTCCGGT ATCGGTAACA ACAATGTTGG CTCTAACAAC 2820

AACAGCGGCC CTAATAACAG TGTTCCTCTT TCTGCTAATA CAGGAAACAC TACTATCAAA 2880

GCCAATTCTA CGACTATCGC AACTTCAAGT TCTGCCGCGG CATCAACGAC TGCACCAATT 2940

TCACAACAGA CTATTCCATC CGGAACACAA TTCAATCATA TTCTGAGTTC CGCCGCAACA 3000

GCTGCAAACT CGGTTAATTC TTTAGGCTTT GGCATGTGTC CTCCTCCACA GAGTTTACAA 3060

ATGGAAATGT TCTTGGACTT AGAATCGTTT CTGCCAGGAA AACAGAGGCG GGTAGACAGG 3120

AAACCCCAGG TTCTGAAAGA ACTGGAAAAT CTTTTACAAA TGTTCGAAGA AGGTTTGCCC 3180

TGCATTGAAC ACGCTTTAAA GGAACAACTT ATTTCAACGC CTATCAAGGA TAATGAGCAT 3240

TAA 3243

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkh.pni  58

         ++ +e+ig+G++g vy+++++ktg++ aik++nl++  +++e++q+ei++l +lk+ +ni

Q: 23    FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDsDEVEDVQREIQFLASLKQiSNI  82

         78899******************************9889*****************9***

S: 59    veylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskk  118

         ++y++s+lk+++lw++me++agGsl++l++     +++E+ i +i+re+l aL+++H+++

Q: 83    TRYYGSYLKDTSLWIIMEHCAGGSLRSLLR---PGKIDEKYIGVIMRELLVALKCIHKDN  139

         ******************************...***************************

S: 119   viHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYd  178

         viHrdika+n+L+t+eg+VkL+dfgvaaq+++t  +r+t+ gtpywmAPEvi  e   Yd

Q: 140   VIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIM-EGVYYD  198

         *****************************************************.7899**

S: 179   ekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekcl  238

         +k+DiwslGIt+ e+a+g+pP++d+e+l+a+ +i k++pp+l+++ ++s+++kef++ cl

Q: 199   TKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDR-SYSTSLKEFIALCL  257

         ******************************************877.**************

S: 239   qknpekRpsasellkhkFl  257

         +++p++R sa++llk+kF+

Q: 258   DEDPKERLSADDLLKSKFI  276

         *****************97

Domain Sequence
(FASTA)

FKRTEVIGRG KFGVVYKGYN VKTGRVYAIK VLNLDSDSDE VEDVQREIQF LASLKQISNI 60

TRYYGSYLKD TSLWIIMEHC AGGSLRSLLR PGKIDEKYIG VIMRELLVAL KCIHKDNVIH 120

RDIKAANVLI TNEGNVKLCD FGVAAQVNQT SLRRQTMAGT PYWMAPEVIM EGVYYDTKVD 180

IWSLGITTYE IATGNPPYCD VEALRAMQLI IKSKPPRLED RSYSTSLKEF IALCLDEDPK 240

ERLSADDLLK SKFI 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005933	; C:cellular bud
GO:0005737	; C:cytoplasm
GO:0000131	; C:incipient cellular bud site
GO:0043332	; C:mating projection tip
GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007118	; P:budding cell apical bud growth
GO:0000902	; P:cell morphogenesis
GO:0031505	; P:fungal-type cell wall organization

KEGG

sce:YHR102W

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013