EKS-SAC-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	354.8	9.9E-107	23	294	272

Status

Reviewed

Ensembl Protein

YIL095W

UniProt Accession

P40494; D6VVJ2; Q02553;

Protein Name

Actin-regulating kinase PRK1

Protein Synonyms/Alias

p53-regulating kinase 1;

Gene Name

PRK1

Gene Synonyms/Alias

PRK1; PAK1; YIL095W;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YIL095W	YIL095W	YIL095W

Organism

Saccharomyces cerevisiae

Functional Description

Involved in regulation of actin cytoskeletonorganization and endocytosis.

Protein Length

810

Protein Sequence
(FASTA)

MNTPQISLYE PGTILTVGSH HAKIIKYLTS GGFAQVYTAE ISPPDPYSNA NIACLKRVIV 60

PHKQGLNTLR AEVDAMKLLR NNKHVVSYID SHAARSVNGI AYEVFVLMEF CERGGLIDFM 120

NTRLQNRLQE SEILEIMSQT VQGITAMHAL QPPLIHRDIK IENVLISHDG LYKVCDFGSV 180

SGVIRPPRNT QEFNYVQHDI LTNTTAQYRS PEMIDLYRGL PIDEKSDIWA LGVFLYKICY 240

YTTPFEKSGE AGILHARYQY PSFPQYSDRL KNLIRLMLME APSQRPNICQ VLEEVSRLQN 300

KPCPIRNFYL LRAMNQNANT QLAGEPSSTT YVPTQKFIPV QSLQSINQPP NMMPVTHVST 360

TPNLGTFPIS INDNNKTEVT AHAGLQVGSH SNLTSPLMKT KSVPLSDEFA SLYYKELHPF 420

QKSQTFKSVE SFQSPQRKSM PPLSLTPVNN DIFDRVSAIN RPNNYVDSET QTIDNMAVPN 480

LKLSPTITSK SLSSTKEIAA PDNINGSKIV RSLSSKLKKV ITGESRGNSP IKSRQNTGDS 540

IRSAFGKLRH GFTGNSVNNS RSASFDNNNV NGNGNNTNRR LVSSSTSSFP KFNSDTKRKE 600

ESDKNQRLEK RRSMPPSILS DFDQHERNNS RTGSRDYYRS HSPVKKTQAS AKTTSKPTLI 660

PDNGNVNINQ EKKESIQRRV HNLLKSSDDP VTYKSASGYG KYTDIGTETS NRHSSVRITP 720

ITEEKFKKTL KDGVLDIKTK SNGKDKSRPP RPPPKPLHLR TEIQKIRNFS RLQSKKLPIE 780

RISSEATETI VDVNVDDLEA DFRKRFPSKV 810

Nucleotide Sequence
(FASTA)

ATGAATACTC CACAGATTAG TCTGTATGAA CCCGGGACAA TATTAACTGT GGGATCTCAT 60

CATGCTAAGA TTATCAAATA CCTTACGAGT GGTGGATTCG CACAAGTATA TACTGCCGAA 120

ATTTCCCCTC CTGACCCATA TAGCAATGCT AACATAGCAT GCTTGAAAAG AGTCATTGTC 180

CCCCATAAAC AGGGTTTAAA TACCTTGAGA GCTGAAGTGG ATGCTATGAA ACTCCTTAGA 240

AATAATAAGC ATGTTGTTTC TTACATAGAT TCACATGCTG CAAGGTCTGT AAATGGTATA 300

GCATATGAGG TGTTTGTGTT AATGGAATTT TGTGAACGTG GAGGTCTTAT AGATTTTATG 360

AACACCAGAT TACAAAATAG ATTACAAGAA TCTGAAATAT TAGAAATTAT GAGTCAAACC 420

GTCCAAGGTA TAACTGCAAT GCACGCTCTG CAGCCGCCAT TGATTCATAG AGATATTAAG 480

ATTGAGAATG TACTTATTTC TCATGATGGC TTGTATAAAG TTTGTGATTT TGGTTCCGTT 540

TCCGGTGTGA TAAGGCCACC TAGAAATACT CAAGAGTTTA ATTATGTTCA ACACGACATC 600

CTAACAAATA CTACAGCTCA GTATAGATCA CCTGAAATGA TTGACCTGTA CAGAGGGTTA 660

CCTATCGACG AAAAATCTGA TATTTGGGCT CTTGGTGTCT TTCTTTACAA AATATGTTAC 720

TATACTACGC CGTTTGAAAA AAGTGGTGAA GCCGGTATAC TACATGCAAG GTATCAATAT 780

CCATCCTTTC CGCAGTATAG TGACAGGTTG AAAAATTTGA TACGTCTTAT GTTAATGGAA 840

GCACCATCTC AGAGGCCAAA TATTTGTCAA GTTTTAGAGG AGGTTTCCAG GTTACAGAAT 900

AAGCCTTGCC CGATTAGAAA TTTTTACTTG TTAAGAGCAA TGAATCAGAA TGCGAATACC 960

CAATTGGCCG GTGAACCGTC TTCGACAACT TATGTTCCAA CACAGAAATT TATTCCCGTA 1020

CAAAGCCTTC AGAGCATCAA CCAGCCACCA AATATGATGC CTGTAACTCA CGTCAGTACT 1080

ACTCCTAATT TGGGTACTTT CCCTATATCT ATTAATGATA ATAACAAGAC AGAAGTAACG 1140

GCGCATGCTG GCTTACAGGT TGGAAGCCAT TCAAATTTGA CTAGTCCCTT AATGAAAACA 1200

AAATCCGTTC CACTTTCTGA TGAATTTGCA TCACTATATT ATAAAGAGCT ACACCCTTTT 1260

CAAAAGTCTC AGACTTTCAA ATCAGTAGAA AGTTTCCAAT CCCCACAAAG GAAGTCTATG 1320

CCTCCATTAT CGCTTACTCC TGTTAATAAT GACATTTTTG ATAGAGTTTC GGCAATAAAT 1380

CGTCCAAATA ACTACGTTGA TTCTGAGACG CAAACTATAG ATAACATGGC TGTGCCAAAC 1440

TTAAAACTAT CTCCCACCAT TACAAGCAAA TCACTAAGCT CCACAAAAGA AATTGCTGCT 1500

CCAGATAATA TAAATGGAAG CAAGATTGTG CGTTCACTAA GCTCTAAGTT AAAAAAGGTT 1560

ATTACTGGTG AATCTCGCGG CAATTCTCCG ATTAAATCAA GGCAAAATAC TGGTGATAGT 1620

ATCAGATCAG CATTTGGTAA GCTTCGTCAT GGGTTTACAG GAAACTCAGT GAACAATAGC 1680

AGGTCTGCTT CCTTTGATAA TAACAATGTC AACGGCAATG GTAACAATAC AAACAGGCGA 1740

TTAGTTTCGT CTTCAACCTC CTCCTTTCCT AAATTTAATT CTGATACCAA AAGAAAAGAG 1800

GAATCAGACA AGAATCAGAG ACTGGAAAAA CGTCGCAGTA TGCCTCCTTC AATTTTATCA 1860

GATTTTGACC AGCATGAGAG GAATAACTCG AGAACTGGAT CAAGGGACTA TTACAGGTCT 1920

CATTCTCCAG TGAAGAAAAC TCAAGCATCA GCTAAAACGA CATCAAAGCC TACTTTGATA 1980

CCAGATAATG GCAACGTTAA TATAAATCAA GAAAAGAAGG AATCAATTCA AAGAAGAGTG 2040

CATAACTTAC TAAAGAGTTC TGATGATCCG GTAACGTATA AATCCGCATC CGGGTATGGT 2100

AAATATACAG ATATTGGTAC AGAAACTTCC AATCGACATT CAAGTGTAAG AATAACACCA 2160

ATCACAGAAG AAAAGTTTAA GAAAACCCTT AAGGATGGTG TTTTGGACAT CAAAACGAAA 2220

AGCAACGGTA AAGATAAATC AAGACCACCA CGTCCACCAC CAAAACCACT ACATTTAAGG 2280

ACAGAAATTC AGAAGATAAG AAACTTTAGT CGTTTACAAT CAAAGAAACT GCCGATTGAA 2340

AGAATTTCCA GCGAAGCCAC AGAAACTATT GTTGATGTTA ACGTAGATGA TTTAGAAGCC 2400

GATTTTAGAA AAAGGTTTCC CAGCAAAGTT TAA 2433

Domain Profile

S: 2     riekvlaeGGfalvylae.....dastgekyalKrilvneeedleeikrEieimkklsgh  56

         +i k+l++GGfa+vy+ae       s+ + ++lKr++v++++ l+++++E+++mk l+++

Q: 23    KIIKYLTSGGFAQVYTAEisppdPYSNANIACLKRVIVPHKQGLNTLRAEVDAMKLLRNN  82

         799***************87776566669*******************************

S: 57    knivklvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvt  116

         k++v+++ds+++++ ++ ++ev++l+e+c++g l+d++n+rl+++ l+e+eil+i+++++

Q: 83    KHVVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTRLQNR-LQESEILEIMSQTV  141

         ****************99*************************99.**************

S: 117   ravaalHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeie  176

         ++++a+Hal++pliHRD+k+eN+l+s++g +++cD+GS++  i+ ++++qe++++q++i

Q: 142   QGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDIL  201

         ************************************************************

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yrsPE+idly++l+ideksDiWaLG++lYk+c++++Pfe+s++  il+++y++P

Q: 202   TNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQYP  261

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlel  269

         + ++ys++lk+li+ ml++ p++Rp+i+qvle+

Q: 262   SFPQYSDRLKNLIRLMLMEAPSQRPNICQVLEE  294

         ******************************986

Domain Sequence
(FASTA)

KIIKYLTSGG FAQVYTAEIS PPDPYSNANI ACLKRVIVPH KQGLNTLRAE VDAMKLLRNN 60

KHVVSYIDSH AARSVNGIAY EVFVLMEFCE RGGLIDFMNT RLQNRLQESE ILEIMSQTVQ 120

GITAMHALQP PLIHRDIKIE NVLISHDGLY KVCDFGSVSG VIRPPRNTQE FNYVQHDILT 180

NTTAQYRSPE MIDLYRGLPI DEKSDIWALG VFLYKICYYT TPFEKSGEAG ILHARYQYPS 240

FPQYSDRLKN LIRLMLMEAP SQRPNICQVL EE 272

Keyword

ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0030479	; C:actin cortical patch
GO:0043332	; C:mating projection tip
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000147	; P:actin cortical patch assembly
GO:0007015	; P:actin filament organization
GO:0000910	; P:cytokinesis
GO:0030100	; P:regulation of endocytosis

KEGG

sce:YIL095W

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013