EKS-SAC-00132
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00132
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/HiskN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinYIL147C
UniProt AccessionP39928; D6VVE0;
Protein NameOsmosensing histidine protein kinase SLN1
Protein Synonyms/Alias Osmolarity two-component system protein SLN1; Tyrosine phosphatase-dependent protein 2;
Gene NameSLN1
Gene Synonyms/Alias SLN1; YPD2; YIL147C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YIL147CYIL147CYIL147C
OrganismSaccharomyces cerevisiae
Functional DescriptionHistidine kinase that acts as a osmosensor at the plasmamembrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.
Protein Length1220
Protein Sequence
(FASTA)
MRFGLPSKLE LTPPFRIGIR TQLTALVSIV ALGSLIILAV TTGVYFTSNY KNLRSDRLYI 60
AAQLKSSQID QTLNYLYYQA YYLASRDALQ SSLTSYVAGN KSADNWVDSL SVIQKFLSSS 120
NLFYVAKVYD SSFNAVLNAT NNGTGDLIPE DVLDSLFPLS TDTPLPSSLE TIGILTDPVL 180
NSTDYLMSMS LPIFANPSII LTDSRVYGYI TIIMSAEGLK SVFNDTTALE HSTIAIISAV 240
YNSQGKASGY HFVFPPYGSR SDLPQKVFSI KNDTFISSAF RNGKGGSLKQ TNILSTRNTA 300
LGYSPCSFNL VNWVAIVSQP ESVFLSPATK LAKIITGTVI AIGVFVILLT LPLAHWAVQP 360
IVRLQKATEL ITEGRGLRPS TPRTISRASS FKRGFSSGFA VPSSLLQFNT AEAGSTTSVS 420
GHGGSGHGSG AAFSANSSMK SAINLGNEKM SPPEEENKIP NNHTDAKISM DGSLNHDLLG 480
PHSLRHNDTD RSSNRSHILT TSANLTEARL PDYRRLFSDE LSDLTETFNT MTDALDQHYA 540
LLEERVRART KQLEAAKIEA EAANEAKTVF IANISHELRT PLNGILGMTA ISMEETDVNK 600
IRNSLKLIFR SGELLLHILT ELLTFSKNVL QRTKLEKRDF CITDVALQIK SIFGKVAKDQ 660
RVRLSISLFP NLIRTMVLWG DSNRIIQIVM NLVSNALKFT PVDGTVDVRM KLLGEYDKEL 720
SEKKQYKEVY IKKGTEVTEN LETTDKYDLP TLSNHRKSVD LESSATSLGS NRDTSTIQEE 780
ITKRNTVANE SIYKKVNDRE KASNDDVSSI VSTTTSSYDN AIFNSQFNKA PGSDDEEGGN 840
LGRPIENPKT WVISIEVEDT GPGIDPSLQE SVFHPFVQGD QTLSRQYGGT GLGLSICRQL 900
ANMMHGTMKL ESKVGVGSKF TFTLPLNQTK EISFADMEFP FEDEFNPESR KNRRVKFSVA 960
KSIKSRQSTS SVATPATNRS SLTNDVLPEV RSKGKHETKD VGNPNMGREE KNDNGGLEQL 1020
QEKNIKPSIC LTGAEVNEQN SLSSKHRSRH EGLGSVNLDR PFLQSTGTAT SSRNIPTVKD 1080
DDKNETSVKI LVVEDNHVNQ EVIKRMLNLE GIENIELACD GQEAFDKVKE LTSKGENYNM 1140
IFMDVQMPKV DGLLSTKMIR RDLGYTSPIV ALTAFADDSN IKECLESGMN GFLSKPIKRP 1200
KLKTILTEFC AAYQGKKNNK 1220
Nucleotide Sequence
(FASTA)
ATGCGATTTG GCCTGCCATC AAAATTGGAA CTCACTCCTC CGTTTAGGAT AGGCATCCGA 60
ACTCAACTAA CGGCACTAGT TAGTATAGTG GCTTTGGGCT CACTGATTAT TCTGGCTGTA 120
ACGACAGGGG TCTATTTTAC CTCGAACTAT AAAAATTTAA GGTCCGATAG ACTGTACATT 180
GCCGCTCAGT TAAAGTCATC ACAGATTGAC CAAACTCTAA ACTACTTATA TTACCAGGCG 240
TACTATTTGG CATCAAGAGA CGCCCTGCAA AGCTCACTAA CAAGTTACGT TGCAGGTAAC 300
AAGAGTGCAG ATAATTGGGT AGATTCCTTG AGTGTGATTC AAAAATTTTT GAGCTCTTCA 360
AACTTGTTTT ATGTTGCTAA AGTTTACGAT TCTTCATTTA ATGCTGTTTT GAACGCTACG 420
AATAATGGAA CTGGTGATCT AATTCCAGAA GATGTTTTAG ACAGTTTGTT CCCATTATCC 480
ACCGATACAC CGCTACCTTC TTCACTGGAA ACTATAGGTA TATTGACGGA TCCAGTACTA 540
AATAGCACCG ACTATTTGAT GTCTATGTCT TTACCTATTT TTGCCAATCC TTCTATTATC 600
TTGACTGATT CAAGGGTTTA CGGATACATT ACTATAATAA TGTCGGCAGA GGGTCTGAAA 660
AGTGTGTTCA ACGATACAAC TGCTTTAGAA CATTCCACAA TTGCCATTAT TTCTGCAGTA 720
TATAATAGTC AAGGCAAAGC TTCAGGGTAT CATTTTGTCT TTCCACCGTA TGGATCACGA 780
TCAGACCTCC CGCAAAAAGT TTTTTCTATA AAAAATGATA CATTCATTAG TAGCGCATTT 840
AGAAACGGGA AGGGAGGGTC TTTGAAACAA ACCAATATCC TTTCTACACG GAATACTGCT 900
TTAGGCTATT CACCATGTTC GTTTAACCTA GTTAATTGGG TCGCGATAGT TTCACAGCCT 960
GAGTCGGTTT TCCTTTCTCC AGCAACGAAA CTAGCAAAAA TCATCACCGG CACTGTCATC 1020
GCTATTGGTG TCTTTGTCAT TTTGTTAACC CTTCCTCTAG CACACTGGGC AGTGCAACCA 1080
ATTGTACGTC TACAAAAGGC AACTGAATTA ATTACAGAGG GGAGAGGCCT TCGACCGAGC 1140
ACCCCAAGAA CGATAAGCAG AGCCAGTTCA TTCAAAAGAG GATTTAGTTC TGGATTTGCT 1200
GTTCCTTCTT CGTTATTACA ATTTAATACT GCTGAAGCTG GCAGCACCAC AAGCGTAAGT 1260
GGCCATGGAG GCAGTGGCCA TGGCAGTGGT GCAGCTTTTT CAGCAAATAG TAGCATGAAA 1320
AGCGCTATAA ACCTTGGAAA TGAGAAAATG TCACCTCCAG AGGAGGAGAA CAAAATACCG 1380
AATAACCACA CCGATGCTAA AATATCAATG GATGGCTCGC TAAATCACGA TTTGCTTGGA 1440
CCACATTCCT TGAGACATAA TGACACTGAC AGAAGTTCCA ATAGATCTCA CATTCTCACA 1500
ACTTCTGCAA ATTTAACTGA AGCTAGGCTA CCAGATTATA GAAGACTATT TTCTGATGAA 1560
CTTTCCGATT TAACAGAAAC CTTCAATACT ATGACAGACG CATTAGACCA ACATTATGCT 1620
CTTCTAGAAG AAAGAGTTAG GGCGAGGACA AAACAACTCG AAGCTGCCAA GATTGAGGCA 1680
GAGGCCGCAA ATGAAGCAAA AACCGTCTTT ATTGCCAATA TTTCGCACGA ATTGAGAACG 1740
CCTTTAAATG GTATTCTGGG TATGACGGCT ATTTCAATGG AAGAAACCGA TGTTAACAAA 1800
ATAAGAAATA GTTTAAAACT CATTTTTAGA TCAGGTGAGC TTTTGCTTCA TATTCTAACG 1860
GAATTGTTAA CTTTTTCCAA AAACGTTCTT CAAAGAACGA AACTGGAGAA AAGAGATTTT 1920
TGCATTACCG ATGTTGCCTT ACAAATAAAA TCGATATTTG GTAAAGTTGC AAAGGATCAG 1980
CGTGTTCGTC TTTCAATATC ATTGTTTCCT AATTTGATAA GGACAATGGT TCTTTGGGGT 2040
GATTCCAACA GAATTATTCA AATTGTGATG AATCTAGTGT CCAATGCACT AAAGTTCACC 2100
CCTGTAGATG GTACCGTTGA TGTAAGAATG AAACTGTTGG GTGAATACGA CAAAGAATTA 2160
AGCGAGAAGA AGCAATACAA AGAAGTGTAT ATCAAAAAAG GGACAGAAGT AACCGAAAAT 2220
TTAGAAACTA CAGATAAATA CGATCTTCCA ACTTTATCGA ACCATAGGAA AAGTGTCGAT 2280
TTAGAATCCA GCGCTACTTC CCTAGGAAGT AATAGAGACA CTTCGACAAT TCAGGAAGAG 2340
ATAACAAAAA GAAATACTGT TGCGAATGAA AGTATCTATA AGAAAGTGAA TGACAGGGAA 2400
AAAGCTTCGA ATGATGATGT ATCTTCTATA GTATCAACAA CTACCAGCTC GTATGATAAC 2460
GCTATCTTCA ATAGTCAGTT CAATAAAGCA CCTGGCTCAG ATGATGAAGA AGGTGGTAAC 2520
CTAGGAAGAC CTATCGAAAA CCCCAAAACG TGGGTTATTT CTATTGAAGT GGAAGACACT 2580
GGGCCTGGTA TTGACCCTTC CTTACAAGAA TCTGTATTTC ATCCATTTGT TCAAGGTGAT 2640
CAAACATTGT CCAGGCAATA TGGTGGTACT GGCTTAGGTC TATCAATCTG TAGACAGTTA 2700
GCAAATATGA TGCATGGAAC GATGAAATTA GAGTCGAAAG TAGGTGTTGG TAGTAAATTC 2760
ACTTTTACCT TGCCATTAAA TCAAACTAAA GAGATCAGTT TTGCAGATAT GGAGTTTCCT 2820
TTTGAGGACG AATTTAATCC TGAGAGTAGA AAGAACAGAA GAGTCAAGTT TAGTGTTGCT 2880
AAAAGCATCA AGAGCCGACA ATCCACATCA TCTGTTGCAA CACCAGCTAC AAATAGAAGT 2940
AGCCTAACCA ACGACGTGCT ACCGGAGGTA AGAAGTAAAG GTAAGCATGA GACGAAAGAT 3000
GTTGGAAATC CTAACATGGG AAGAGAAGAA AAAAACGACA ATGGAGGGCT TGAACAACTG 3060
CAGGAAAAAA ATATTAAACC TTCTATATGT CTTACAGGTG CTGAAGTTAA CGAACAAAAT 3120
TCCTTGTCTT CTAAGCATCG TTCTCGACAT GAAGGTCTAG GTTCTGTCAA TCTTGATAGA 3180
CCATTTTTGC AAAGTACTGG TACAGCCACA TCAAGTAGAA ACATCCCCAC AGTCAAAGAC 3240
GACGATAAAA ATGAAACAAG TGTCAAAATT TTGGTTGTAG AAGATAATCA TGTAAATCAG 3300
GAAGTTATCA AAAGAATGTT GAACTTGGAG GGCATTGAAA ATATTGAACT GGCTTGCGAT 3360
GGCCAAGAAG CATTCGACAA AGTTAAAGAA TTGACATCTA AGGGCGAAAA TTATAATATG 3420
ATTTTCATGG ATGTCCAGAT GCCTAAAGTG GATGGTTTAC TTTCTACCAA GATGATAAGG 3480
CGCGATTTAG GTTATACCTC ACCTATTGTC GCTCTAACCG CTTTTGCTGA CGATAGCAAC 3540
ATTAAAGAAT GTTTGGAATC AGGAATGAAC GGATTTTTAT CGAAACCAAT CAAAAGACCA 3600
AAATTGAAAA CTATTCTTAC TGAGTTTTGT GCAGCATATC AGGGAAAGAA AAATAACAAA 3660
TGA 3663
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
Keyword3D-structure; ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00418
EKS-ANC-00436
EKS-BOT-00448
EKS-CAJ-00453
EKS-CAF-00447
EKS-CAP-00482
EKS-CHH-00030
EKS-DAR-00849
EKS-DRM-00211
EKS-EQC-00438
EKS-ERE-00045
EKS-FEC-00427
EKS-GAG-00377
EKS-GAA-00542
EKS-GOG-00440
EKS-HOS-00455
EKS-ICT-00428
EKS-LAC-00462
EKS-LOA-00455
EKS-MAM-00446
EKS-MAE-00061
EKS-MEG-00369
EKS-MOD-00437
EKS-MUM-00479
EKS-MUP-00441
EKS-MYL-00442
EKS-NOL-00407
EKS-OCP-00110
EKS-ORN-00565
EKS-ORA-00391
EKS-ORC-00419
EKS-ORL-00517
EKS-OTG-00451
EKS-PAT-00423
EKS-PES-00394
EKS-PEM-00247
EKS-POA-00437
EKS-PTV-00156
EKS-RAN-00460
EKS-SAH-00414
EKS-SOA-00041
EKS-SUS-00395
EKS-TAG-00513
EKS-TAR-00559
EKS-TAS-00061
EKS-TEN-00562
EKS-TUB-00041
EKS-TUT-00160
EKS-VIP-00082
EKS-XIM-00559
EKS-SCP-00007
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0009927; F:histidine phosphotransfer kinase activity
GO:0046872; F:metal ion binding
GO:0005034; F:osmosensor activity
GO:0004673; F:protein histidine kinase activity
GO:0000156; F:two-component response regulator activity
GO:0000155; F:two-component sensor activity
GO:0035556; P:intracellular signal transduction
GO:0006469; P:negative regulation of protein kinase activity
GO:0007234; P:osmosensory signaling pathway via two-component system
GO:0018106; P:peptidyl-histidine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0023014; P:signal transduction by phosphorylation
KEGG
sce:YIL147C;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR011006; CheY-like_superfamily.
IPR004358; Sig_transdc_His_kin-like_C.
IPR003661; Sig_transdc_His_kin_sub1_dim/P.
IPR005467; Sig_transdc_His_kinase_core.
IPR009082; Sig_transdc_His_kinase_dimeric.
IPR001789; Sig_transdc_resp-reg_receiver.
Pfam
PF02518; HATPase_c; 1.
PF00512; HisKA; 1.
PF00072; Response_reg; 1.
SMARTs
SM00387; HATPase_c; 1.
SM00388; HisKA; 1.
SM00448; REC; 1.
Prosites
PS50109; HIS_KIN; 1.
PS50110; RESPONSE_REGULATORY; 1.
Prints
PR00344; BCTRLSENSOR.
Created Date20-Feb-2013