EPS-SAC-00002

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00002

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	216.7	3.7E-65	11	171	161

Status

Reviewed

Ensembl Protein

YIR026C

UniProt Accession

Q02256; D6VVV7;

Protein Name

Tyrosine-protein phosphatase YVH1

Protein Synonyms/Alias

PTPase YVH1;

Gene Name

YVH1

Gene Synonyms/Alias

YVH1; YIR026C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YIR026C	YIR026C	YIR026C

Organism

Saccharomyces cerevisiae

Functional Description

May be directly involved in signal transduction and/orcell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine- protein phosphate as well as with serine-protein phosphate.

Protein Length

364

Protein Sequence
(FASTA)

MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV IPEYLIRKGY 60

TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR LVDFKKKPQR GAVFAHCQAG 120

LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK KPSVEPNENF MEQLHLFEKM GGDFVDFDNP 180

AYKQWKLKQS IKLDPSGSEL VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA 240

LSTSFIAHDP PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE 300

LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA LPNMVNFESE 360

KVNR 364

Nucleotide Sequence
(FASTA)

ATGGCTGGAA ATGCAAACTC AGTAGACGAG GAAGTTACCA GGATATTAGG AGGCATATAT 60

CTTGGCGGAA TCCGTCCAAT TATTGACCAC AGACCATTGG GTGCAGAATT TAACATTACT 120

CATATTCTTT CTGTTATCAA ATTCCAGGTC ATTCCAGAGT ATCTAATAAG GAAAGGTTAC 180

ACGCTAAAAA ACATACCCAT CGATGATGAT GATGTGACTG ATGTGCTGCA ATACTTCGAT 240

GAAACGAACC GATTCATTGA TCAATGCTTG TTCCCCAATG AAGTTGAGTA TTCGCCCAGA 300

TTAGTAGATT TCAAGAAGAA ACCACAACGT GGTGCTGTTT TTGCTCATTG TCAAGCAGGA 360

CTCTCGAGAT CTGTAACCTT CATAGTAGCC TACCTAATGT ATCGTTATGG ATTGTCACTA 420

TCAATGGCTA TGCACGCTGT CAAGAGGAAG AAACCGAGTG TTGAGCCAAA CGAGAATTTC 480

ATGGAACAAT TACATCTCTT TGAGAAAATG GGTGGAGATT TTGTCGATTT CGACAACCCA 540

GCCTATAAGC AGTGGAAGCT GAAGCAATCT ATCAAGTTAG ATCCATCGGG CAGCGAATTG 600

GTCTCCAATT CTGGAATGTT TAAAGATTCG GAGTCGTCGC AAGACTTGGA TAAATTAACT 660

GAAGCTGAGA AGAGCAAGGT CACCGCAGTG AGATGTAAGA AGTGCAGAAC CAAATTGGCG 720

TTATCTACAT CTTTCATCGC GCATGACCCA CCAAGTAAGG AATCATCAGA GGGACACTTC 780

ATCAAGAGGG CCGCCAACTC CCATCGTATT ATTGATATTC AAGAGTCACA AGCAAATTGC 840

TCTCATTTTT TCATCGAACC TTTAAAATGG ATGCAACCTG AACTACAAGG CAAGCAAGAG 900

TTAGAAGGGA AGTTTTCATG TCCAGGCTGT TCAAGTAAAG TTGGCGGTTA CAACTGGAAA 960

GGATCTAGGT GCAGTTGTGG TAAGTGGGTC ATCCCCGCTA TCCACCTGCA AACTAGTAAA 1020

GTGGATCAAT TTCCCTTACA ATCCACTGCT TTGCCCAACA TGGTTAATTT TGAATCCGAG 1080

AAAGTAAATA GATAA 1095

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         evt+il+g+ylg++++++d+r+L   g++++i+++lsvik+qviPeyli+kg+t+knip+

Q: 11    EVTRILGGIYLGGIRPIIDHRPL---GAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPI  67

         69*********************...**********************************

S: 61    dDsdvtdllqyfdeaaefidea.................kekggkvlvHCaaGvsRSatl  103

         dD+dvtd+lqyfde+++fid++                 k+++g+v++HC+aG+sRS+t+

Q: 68    DDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGAVFAHCQAGLSRSVTF  127

         ************************************************************

S: 104   vlaYLmkveglslsdAieavkrkrpsiepnegfleQLlelekkl  147

         ++aYLm+++glsls+A++avkrk+ps+epne+f+eQL+++ek++

Q: 128   IVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMG  171

         ******************************************97

Domain Sequence
(FASTA)

EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV IPEYLIRKGY TLKNIPIDDD 60

DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR LVDFKKKPQR GAVFAHCQAG LSRSVTFIVA 120

YLMYRYGLSL SMAMHAVKRK KPSVEPNENF MEQLHLFEKM G 161

Keyword

Complete proteome; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome; Stress response.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0030476	; P:ascospore wall assembly
GO:0019933	; P:cAMP-mediated signaling
GO:0007126	; P:meiosis
GO:0006950	; P:response to stress
GO:0000027	; P:ribosomal large subunit assembly

KEGG

sce:YIR026C

;

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS00383	; TYR_PHOSPHATASE_1; FALSE_NEG.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013