EKS-SAC-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	467.5	4.8E-141	38	386	349

Status

Reviewed

Ensembl Protein

YJL106W

UniProt Accession

P32581; D6VW78;

Protein Name

Meiosis induction protein kinase IME2/SME1

Protein Synonyms/Alias

Gene Name

IME2

Gene Synonyms/Alias

IME2; SME1; YJL106W; J0817;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YJL106W	YJL106W	YJL106W

Organism

Saccharomyces cerevisiae

Functional Description

Protein kinase which is essential for the initiation ofmeiosis and sporulation.

Protein Length

645

Protein Sequence
(FASTA)

MVEKRSRQSS SSGSEFSVPP DVDNPPLSIP LKTLSDRYQL IEKLGAGSFG CVTLAKAQFP 60

LSNILGKQHD IRGTLMDQPK NGHQNYITKT QGVVAIKTMM TKLHTLQDYT RVREIKFILA 120

IPANDHLIQI FEVFIDSENY QLHIVMECME QNLYQMMKHR RRRVFSIPSL KSILSQILAG 180

LKHIHEHNFF HRDLKPENIL ITPSTQYFEK EYMNQIGYQD NYVIKLADFG LARHVENKNP 240

YTAYVSTRWY RSPEILLRSG YYSKPLDIWA FGCVAVEVTV FRALFPGANE IDQIWKILEV 300

LGTPIKRSDF VNTNHITAPP PGGFWDDASN LVHKLNLKLP YVEGSSLDHL LSSSQLSDLS 360

EVVKKCLRWD PNERATAQEL CEMPFFENTV ASQVDARGNV TNTEQALIFA GINPVATNTK 420

PIYFNSSTKL PAETESNDID ISNNDHDSHA MCSPTLNQEK LTLVEFLNEF VEEDNDDHSI 480

PDVGTDSTIS DSIDETELSK EIRNNLALCQ LPDEEVLDHS LSNIRQLTND IEIINKDEAD 540

NMEQLFFDLE IPEKDEFQRK QPFNEHADID EDIVLPYVNN SNYTHTDRSH HRGDNVLGDA 600

SLGDSFNSMP DFTPRNFLIP TLKKSREKFE PHLSNSNQHF GNVTF 645

Nucleotide Sequence
(FASTA)

ATGGTTGAAA AACGTAGTAG ACAGAGTTCC AGTAGTGGCT CAGAGTTCAG TGTTCCACCT 60

GATGTCGATA ACCCGCCACT TTCTATCCCT TTGAAGACTT TATCAGACAG ATATCAGCTG 120

ATCGAAAAAC TAGGTGCAGG ATCATTTGGT TGTGTAACTT TAGCCAAAGC GCAATTTCCT 180

TTATCGAACA TATTGGGTAA ACAACATGAT ATAAGGGGTA CTTTAATGGA TCAGCCTAAA 240

AATGGTCACC AAAACTATAT AACAAAGACA CAAGGTGTAG TGGCTATAAA GACAATGATG 300

ACAAAACTGC ATACACTCCA GGATTATACG AGGGTCAGAG AAATTAAGTT CATACTGGCA 360

ATCCCAGCGA ATGACCATCT GATACAAATT TTTGAGGTCT TTATTGACTC TGAAAATTAC 420

CAATTACATA TCGTAATGGA ATGTATGGAG CAAAACCTAT ATCAAATGAT GAAACATAGA 480

AGGCGCCGAG TTTTTTCGAT TCCTTCTTTG AAATCTATTC TATCGCAGAT ACTGGCTGGG 540

TTAAAACACA TCCACGAACA TAATTTCTTC CACAGAGATT TAAAACCTGA AAATATTCTT 600

ATCACACCAA GTACCCAGTA TTTTGAAAAG GAGTACATGA ACCAGATTGG ATATCAAGAT 660

AACTATGTCA TTAAACTTGC AGATTTTGGT TTGGCACGCC ATGTTGAAAA TAAAAACCCG 720

TATACGGCCT ACGTTTCCAC AAGATGGTAT AGATCGCCTG AAATATTATT AAGAAGTGGT 780

TACTATTCCA AACCTTTGGA TATTTGGGCA TTCGGGTGCG TGGCGGTGGA AGTTACTGTA 840

TTCAGAGCTC TCTTCCCCGG TGCTAACGAA ATCGATCAGA TATGGAAAAT TTTAGAAGTT 900

CTTGGTACAC CTATCAAACG TTCTGATTTT GTTAATACAA ACCACATCAC AGCTCCACCA 960

CCTGGTGGAT TTTGGGATGA TGCCAGTAAT TTGGTCCATA AATTAAACTT GAAATTGCCT 1020

TATGTAGAAG GTTCATCGTT GGATCATCTA CTTTCTAGCT CCCAACTATC CGATTTATCT 1080

GAGGTTGTCA AAAAGTGTTT AAGATGGGAT CCTAATGAAA GGGCAACAGC CCAAGAGCTT 1140

TGTGAAATGC CATTTTTTGA AAACACCGTG GCATCCCAAG TAGACGCAAG AGGCAATGTG 1200

ACTAATACAG AACAAGCATT GATTTTTGCA GGTATAAATC CAGTAGCGAC CAACACAAAG 1260

CCCATATATT TTAACTCTTC AACAAAATTG CCCGCAGAAA CAGAGTCTAA TGATATTGAT 1320

ATCAGCAACA ACGATCACGA TTCTCATGCT ATGTGCTCAC CAACATTAAA TCAAGAAAAA 1380

CTAACTTTGG TAGAATTTTT AAACGAATTC GTTGAAGAAG ATAATGATGA TCACTCAATA 1440

CCTGATGTTG GAACAGATTC TACCATTTCA GATTCTATTG ATGAGACTGA ATTATCAAAA 1500

GAAATTCGTA ATAATTTGGC CCTTTGTCAA CTACCAGATG AAGAAGTCTT AGATCATTCA 1560

TTATCGAATA TTAGGCAGTT GACAAATGAT ATTGAAATTA TAAATAAAGA TGAAGCAGAC 1620

AACATGGAAC AGCTATTTTT TGACCTGGAA ATTCCTGAAA AGGATGAGTT TCAGAGAAAA 1680

CAACCATTTA ATGAACATGC AGATATTGAT GAAGACATCG TTCTACCATA TGTGAACAAC 1740

TCAAATTACA CACATACAGA TAGGTCACAT CATAGAGGTG ATAATGTTTT GGGTGATGCC 1800

TCTTTAGGCG ATTCGTTTAA TTCAATGCCA GATTTTACTC CAAGAAATTT CTTGATACCT 1860

ACATTAAAAA AATCACGGGA AAAGTTCGAG CCTCATCTAT CCAATTCAAA CCAACATTTT 1920

GGAAATGTAA CCTTCTAA 1938

Domain Profile

S: 1     yklikklGdGtfgevllaks..............................lktgelvaik  30

         y+li+klG+G+fg+v+lak+                              +kt+++vaik

Q: 38    YQLIEKLGAGSFGCVTLAKAqfplsnilgkqhdirgtlmdqpknghqnyiTKTQGVVAIK  97

         99**********************************************************

S: 31    kmkrkfesleevtnlrevkslkklnahdniiklkeviidrendslylvlelmeenlyqli  90

         +m++k+++l+++t++re+k++ +++a+d++i+++ev+id+en++l++v+e+me+nlyq++

Q: 98    TMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMM  157

         ************************************************************

S: 91    kd.rrkllsesklksilyqilkglafihkhgffhrdlkPenilikgse............  137

         k+ rr+++s+++lksil+qil+gl++ih+h+ffhrdlkPenili++s+

Q: 158   KHrRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTqyfekeymnqig  217

         **8889*****************************************9************

S: 138   .....lvkladfGlarevrsknPytdyvstrwyraPevllrsgvysspldlwavGcvlae  192

              ++kladfGlar+v++knPyt+yvstrwyr+Pe+llrsg+ys+pld+wa+Gcv++e

Q: 218   yqdnyVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVE  277

         ************************************************************

S: 193   vavlrplfPGaseidqifkilevlGtPkkke................wdeayklasalnl  236

         v+v+r+lfPGa+eidqi+kilevlGtP+k++                wd+a++l+++lnl

Q: 278   VTVFRALFPGANEIDQIWKILEVLGTPIKRSdfvntnhitapppggfWDDASNLVHKLNL  337

         ************************************************************

S: 237   kfpqvegsslktlvsnaskeal.ellkdllaydPderataqqalkypyf  284

         k+p+vegssl++l+s+++ ++l e++k++l++dP+erataq+++++p+f

Q: 338   KLPYVEGSSLDHLLSSSQLSDLsEVVKKCLRWDPNERATAQELCEMPFF  386

         **********************99************************9

Domain Sequence
(FASTA)

YQLIEKLGAG SFGCVTLAKA QFPLSNILGK QHDIRGTLMD QPKNGHQNYI TKTQGVVAIK 60

TMMTKLHTLQ DYTRVREIKF ILAIPANDHL IQIFEVFIDS ENYQLHIVME CMEQNLYQMM 120

KHRRRRVFSI PSLKSILSQI LAGLKHIHEH NFFHRDLKPE NILITPSTQY FEKEYMNQIG 180

YQDNYVIKLA DFGLARHVEN KNPYTAYVST RWYRSPEILL RSGYYSKPLD IWAFGCVAVE 240

VTVFRALFPG ANEIDQIWKI LEVLGTPIKR SDFVNTNHIT APPPGGFWDD ASNLVHKLNL 300

KLPYVEGSSL DHLLSSSQLS DLSEVVKKCL RWDPNERATA QELCEMPFF 349

Keyword

ATP-binding; Complete proteome; Kinase; Meiosis; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Sporulation; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007126	; P:meiosis
GO:0040020	; P:regulation of meiosis
GO:0030435	; P:sporulation resulting in formation of a cellular spore

KEGG

sce:YJL106W

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013