EKS-SAC-00088

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00088

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	338.1	1.9E-101	2094	2388	295

Status

Reviewed

Ensembl Protein

YKL203C

UniProt Accession

P32600; D6VX00;

Protein Name

Serine/threonine-protein kinase TOR2

Protein Synonyms/Alias

Dominant rapamycin resistance protein 2; Phosphatidylinositol 4-kinase TOR2; PI4-kinase TOR2; PI4K TOR2; PtdIns-4-kinase TOR2; Target of rapamycin kinase 2; Temperature-sensitive CSG2 suppressor protein 14;

Gene Name

TOR2

Gene Synonyms/Alias

TOR2; DRR2, TSC14; YKL203C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YKL203C	YKL203C	YKL203C

Organism

Saccharomyces cerevisiae

Functional Description

Phosphatidylinositol 3-kinase homolog, component of bothTORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4. TORC2 regulates cell cycle-dependent polarization of the actin- cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway by activating the RHO1 guanine nucleotide exchange factor ROM2. TORC2 phosphorylates the AGC kinase YPK2, an upstream effector of the cell integrity pathway. TORC2 negatively regulates calcineurin-dependent stress signaling via phosphorylation of its effector SLM1-SLM2.

Protein Length

2474

Protein Sequence
(FASTA)

MNKYINKYTT PPNLLSLRQR AEGKHRTRKK LTHKSHSHDD EMSTTSNTDS NHNGPNDSGR 60

VITGSAGHIG KISFVDSELD TTFSTLNLIF DKLKSDVPQE RASGANELST TLTSLAREVS 120

AEQFQRFSNS LNNKIFELIH GFTSSEKIGG ILAVDTLISF YLSTEELPNQ TSRLANYLRV 180

LIPSSDIEVM RLAANTLGRL TVPGGTLTSD FVEFEVRTCI DWLTLTADNN SSSSKLEYRR 240

HAALLIIKAL ADNSPYLLYP YVNSILDNIW VPLRDAKLII RLDAAVALGK CLTIIQDRDP 300

ALGKQWFQRL FQGCTHGLSL NTNDSVHATL LVFRELLSLK APYLRDKYDD IYKSTMKYKE 360

YKFDVIRREV YAILPLLAAF DPAIFTKKYL DRIMVHYLRY LKNIDMNAAN NSDKPFILVS 420

IGDIAFEVGS SISPYMTLIL DNIREGLRTK FKVRKQFEKD LFYCIGKLAC ALGPAFAKHL 480

NKDLLNLMLN CPMSDHMQET LMILNEKIPS LESTVNSRIL NLLSISLSGE KFIQSNQYDF 540

NNQFSIEKAR KSRNQSFMKK TGESNDDITD AQILIQCFKM LQLIHHQYSL TEFVRLITIS 600

YIEHEDSSVR KLAALTSCDL FIKDDICKQT SVHALHSVSE VLSKLLMIAI TDPVAEIRLE 660

ILQHLGSNFD PQLAQPDNLR LLFMALNDEI FGIQLEAIKI IGRLSSVNPA YVVPSLRKTL 720

LELLTQLKFS NMPKKKEESA TLLCTLINSS DEVAKPYIDP ILDVILPKCQ DASSAVASTA 780

LKVLGELSVV GGKEMTRYLK ELMPLIINTF QDQSNSFKRD AALTTLGQLA ASSGYVVGPL 840

LDYPELLGIL INILKTENNP HIRRGTVRLI GILGALDPYK HREIEVTSNS KSSVEQNAPS 900

IDIALLMQGV SPSNDEYYPT VVIHNLMKIL NDPSLSIHHT AAIQAIMHIF QNLGLRCVSF 960

LDQIIPGIIL VMRSCPPSQL DFYFQQLGSL ISIVKQHIRP HVEKIYGVIR EFFPIIKLQI 1020

TIISVIESIS KALEGEFKRF VPETLTFFLD ILENDQSNKR IVPIRILKSL VTFGPNLEDY 1080

SHLIMPIVVR MTEYSAGSLK KISIITLGRL AKNINLSEMS SRIVQALVRI LNNGDRELTK 1140

ATMNTLSLLL LQLGTDFVVF VPVINKALLR NRIQHSVYDQ LVNKLLNNEC LPTNIIFDKE 1200

NEVPERKNYE DEMQVTKLPV NQNILKNAWY CSQQKTKEDW QEWIRRLSIQ LLKESPSACL 1260

RSCSSLVSVY YPLARELFNA SFSSCWVELQ TSYQEDLIQA LCKALSSSEN PPEIYQMLLN 1320

LVEFMEHDDK PLPIPIHTLG KYAQKCHAFA KALHYKEVEF LEEPKNSTIE ALISINNQLH 1380

QTDSAIGILK HAQQHNELQL KETWYEKLQR WEDALAAYNE KEAAGEDSVE VMMGKLRSLY 1440

ALGEWEELSK LASEKWGTAK PEVKKAMAPL AAGAAWGLEQ WDEIAQYTSV MKSQSPDKEF 1500

YDAILCLHRN NFKKAEVHIF NARDLLVTEL SALVNESYNR AYNVVVRAQI IAELEEIIKY 1560

KKLPQNSDKR LTMRETWNTR LLGCQKNIDV WQRILRVRSL VIKPKEDAQV RIKFANLCRK 1620

SGRMALAKKV LNTLLEETDD PDHPNTAKAS PPVVYAQLKY LWATGLQDEA LKQLINFTSR 1680

MAHDLGLDPN NMIAQSVPQQ SKRVPRHVED YTKLLARCFL KQGEWRVCLQ PKWRLSNPDS 1740

ILGSYLLATH FDNTWYKAWH NWALANFEVI SMLTSVSKKK QEGSDASSVT DINEFDNGMI 1800

GVNTFDAKEV HYSSNLIHRH VIPAIKGFFH SISLSESSSL QDALRLLTLW FTFGGIPEAT 1860

QAMHEGFNLI QIGTWLEVLP QLISRIHQPN QIVSRSLLSL LSDLGKAHPQ ALVYPLMVAI 1920

KSESLSRQKA ALSIIEKMRI HSPVLVDQAE LVSHELIRMA VLWHEQWYEG LDDASRQFFG 1980

EHNTEKMFAA LEPLYEMLKR GPETLREISF QNSFGRDLND AYEWLMNYKK SKDVSNLNQA 2040

WDIYYNVFRK IGKQLPQLQT LELQHVSPKL LSAHDLELAV PGTRASGGKP IVKISKFEPV 2100

FSVISSKQRP RKFCIKGSDG KDYKYVLKGH EDIRQDSLVM QLFGLVNTLL QNDAECFRRH 2160

LDIQQYPAIP LSPKSGLLGW VPNSDTFHVL IREHREAKKI PLNIEHWVML QMAPDYDNLT 2220

LLQKVEVFTY ALNNTEGQDL YKVLWLKSRS SETWLERRTT YTRSLAVMSM TGYILGLGDR 2280

HPSNLMLDRI TGKVIHIDFG DCFEAAILRE KFPEKVPFRL TRMLTYAMEV SGIEGSFRIT 2340

CENVMKVLRD NKGSLMAILE AFAFDPLINW GFDLPTKKIE EETGIQLPVM NANELLSNGA 2400

ITEEEVQRVE NEHKNAIRNA RAMLVLKRIT DKLTGNDIRR FNDLDVPEQV DKLIQQATSV 2460

ENLCQHYIGW CPFW 2474

Nucleotide Sequence
(FASTA)

ATGAATAAAT ACATTAACAA ATACACCACG CCACCTAACT TATTGTCTTT ACGACAAAGG 60

GCCGAAGGCA AACACAGAAC AAGAAAGAAA CTTACACACA AATCGCACTC CCACGATGAT 120

GAGATGTCAA CTACTTCAAA CACAGATTCC AATCACAATG GGCCCAATGA CTCTGGTAGA 180

GTGATCACTG GTTCTGCTGG TCATATTGGT AAAATATCCT TTGTAGATTC AGAACTAGAT 240

ACAACATTTT CTACTTTAAA TTTGATTTTT GATAAACTTA AAAGCGATGT GCCACAAGAA 300

CGAGCCTCTG GCGCTAATGA ATTAAGCACT ACTTTGACCT CATTAGCAAG GGAAGTATCT 360

GCTGAGCAAT TTCAAAGGTT TAGCAACAGT TTAAACAATA AGATATTTGA ACTTATTCAC 420

GGGTTTACTT CAAGTGAGAA GATAGGTGGT ATTCTTGCTG TTGATACTCT GATCTCATTC 480

TACCTGAGTA CAGAGGAGCT GCCAAACCAA ACTTCAAGAC TGGCGAACTA TTTACGTGTT 540

TTAATTCCAT CCAGTGACAT TGAAGTTATG AGATTAGCGG CTAACACCTT AGGTAGATTG 600

ACCGTGCCAG GTGGTACATT AACATCAGAT TTCGTCGAAT TTGAGGTCAG AACTTGCATT 660

GATTGGCTTA CTCTGACAGC AGATAATAAC TCATCGAGCT CTAAGTTGGA ATACAGGAGA 720

CATGCTGCGC TATTAATCAT AAAGGCATTA GCAGACAATT CACCCTATCT TTTATACCCT 780

TACGTTAACT CTATCTTAGA CAATATTTGG GTGCCATTAA GGGATGCAAA GTTAATTATA 840

CGATTAGATG CCGCAGTGGC ATTGGGTAAA TGTCTTACTA TTATTCAGGA TAGAGACCCT 900

GCTTTGGGAA AACAGTGGTT TCAAAGATTA TTTCAAGGTT GTACACATGG CTTAAGTCTC 960

AATACGAATG ATTCAGTGCA TGCTACTCTG TTGGTATTTC GAGAATTACT CAGCTTGAAA 1020

GCACCTTATC TCAGGGATAA ATATGATGAT ATTTACAAAT CTACTATGAA GTACAAGGAA 1080

TATAAATTTG ATGTTATAAG GAGAGAAGTT TATGCTATTT TACCTCTTTT AGCTGCTTTT 1140

GACCCTGCCA TTTTCACAAA GAAATATCTC GATAGGATAA TGGTTCATTA TTTAAGATAT 1200

TTGAAGAACA TCGATATGAA TGCTGCAAAT AATTCGGATA AACCTTTTAT ATTAGTTTCT 1260

ATAGGTGATA TTGCATTTGA AGTTGGTTCG AGCATTTCAC CCTATATGAC ACTTATTCTG 1320

GATAATATTA GGGAAGGCTT AAGAACGAAA TTCAAAGTTA GAAAACAATT CGAGAAGGAT 1380

TTATTTTATT GCATTGGTAA ATTAGCTTGT GCTTTGGGCC CAGCTTTTGC TAAGCACTTG 1440

AACAAAGATC TTCTTAATTT GATGTTAAAC TGTCCAATGT CCGACCATAT GCAGGAGACT 1500

TTAATGATCC TTAACGAGAA AATACCCTCT TTGGAATCTA CCGTTAATTC GAGGATACTA 1560

AATTTACTGT CGATATCCTT ATCTGGTGAA AAATTTATTC AATCAAACCA ATACGATTTT 1620

AATAATCAAT TTTCCATTGA AAAGGCTCGT AAATCAAGAA ACCAAAGTTT CATGAAAAAA 1680

ACTGGTGAAT CTAATGACGA TATTACAGAT GCCCAAATTT TGATTCAGTG TTTTAAAATG 1740

CTGCAACTAA TTCATCATCA ATATTCCTTG ACGGAGTTTG TTAGGCTTAT AACCATTTCT 1800

TACATTGAGC ATGAGGATTC GTCTGTCAGA AAATTGGCAG CATTAACGTC GTGTGATTTA 1860

TTTATCAAAG ACGATATATG TAAACAAACA TCAGTTCATG CTTTACACTC GGTTTCTGAA 1920

GTGCTAAGTA AGCTATTAAT GATCGCAATA ACTGATCCGG TTGCAGAAAT TAGATTGGAA 1980

ATTCTTCAGC ATTTGGGGTC AAATTTTGAT CCTCAATTGG CCCAACCAGA CAATTTACGC 2040

CTACTTTTCA TGGCGCTGAA CGATGAGATT TTTGGTATTC AATTGGAAGC TATCAAAATA 2100

ATAGGCAGAT TGAGTTCTGT CAACCCCGCT TATGTAGTTC CTTCTTTGAG GAAAACTTTA 2160

CTGGAACTAT TAACGCAATT GAAGTTCTCA AATATGCCAA AAAAAAAGGA GGAAAGTGCA 2220

ACTCTATTAT GTACGCTGAT AAATTCCAGC GATGAAGTAG CGAAACCTTA TATTGATCCT 2280

ATTCTAGACG TCATTCTTCC TAAATGCCAG GATGCTTCAT CTGCCGTAGC ATCCACCGCT 2340

TTAAAGGTTT TGGGTGAACT ATCTGTTGTT GGAGGAAAAG AAATGACGCG TTACTTAAAG 2400

GAATTGATGC CATTGATCAT TAACACATTT CAGGACCAAT CAAACTCTTT TAAAAGAGAT 2460

GCCGCCTTAA CAACATTAGG ACAGCTGGCT GCTTCCTCTG GTTATGTTGT TGGCCCTTTA 2520

CTAGACTACC CAGAGTTACT TGGCATTTTG ATAAATATTC TTAAGACTGA AAACAACCCT 2580

CATATCAGGC GTGGAACTGT TCGTTTGATT GGTATATTAG GCGCTCTTGA TCCATATAAG 2640

CACAGAGAAA TAGAAGTCAC ATCAAACTCA AAGAGTTCAG TAGAGCAAAA TGCTCCTTCA 2700

ATCGACATCG CATTGCTAAT GCAAGGGGTA TCTCCATCCA ACGATGAATA TTACCCCACT 2760

GTAGTTATCC ACAATCTGAT GAAGATATTG AATGATCCAT CGTTGTCAAT CCATCACACG 2820

GCTGCTATTC AAGCTATTAT GCATATTTTT CAAAACCTTG GTTTACGATG TGTCTCCTTT 2880

TTGGATCAAA TTATTCCAGG TATCATTTTA GTCATGCGTT CATGCCCGCC GTCCCAACTT 2940

GACTTTTATT TTCAGCAACT GGGATCTCTC ATCTCAATTG TCAAGCAACA TATTAGGCCC 3000

CATGTCGAGA AAATTTATGG TGTGATCAGG GAGTTTTTCC CGATCATTAA ACTACAAATC 3060

ACAATTATTT CTGTCATAGA ATCGATATCT AAGGCTCTGG AAGGTGAGTT TAAAAGATTT 3120

GTTCCCGAGA CTCTAACCTT TTTCCTTGAT ATTCTTGAGA ACGACCAGTC TAATAAAAGG 3180

ATCGTTCCGA TTCGTATATT AAAATCTTTG GTTACTTTTG GGCCGAATCT AGAAGACTAT 3240

TCCCATTTGA TTATGCCTAT CGTTGTTAGA ATGACTGAGT ATTCTGCTGG AAGTCTAAAG 3300

AAAATCTCCA TTATAACTTT GGGTAGATTA GCAAAGAATA TCAACCTCTC TGAAATGTCA 3360

TCAAGAATTG TTCAGGCGTT GGTAAGAATT TTGAATAATG GGGATAGAGA ACTAACAAAA 3420

GCAACCATGA ATACGCTAAG TTTGCTCCTT TTACAACTAG GTACCGACTT TGTGGTCTTT 3480

GTGCCAGTGA TTAACAAGGC GTTATTGAGG AATAGGATTC AGCATTCAGT GTACGATCAA 3540

CTGGTTAATA AATTACTGAA CAATGAATGC TTGCCAACAA ATATCATATT TGACAAGGAG 3600

AACGAAGTAC CTGAAAGGAA AAATTATGAA GACGAAATGC AAGTAACGAA ATTACCGGTA 3660

AACCAAAATA TCCTAAAGAA TGCATGGTAT TGTTCTCAAC AGAAGACCAA AGAAGATTGG 3720

CAAGAATGGA TAAGAAGGCT ATCTATTCAG CTTCTAAAGG AATCACCTTC AGCTTGTCTA 3780

CGATCCTGTT CGAGTTTAGT CAGCGTTTAT TATCCGTTGG CGAGAGAATT GTTTAATGCT 3840

TCATTCTCAA GTTGCTGGGT TGAGCTTCAA ACGTCATACC AAGAGGATTT GATTCAAGCA 3900

TTATGCAAGG CTTTATCATC CTCTGAAAAC CCACCCGAGA TTTATCAAAT GTTGTTAAAT 3960

TTAGTGGAAT TTATGGAGCA CGATGACAAA CCATTGCCTA TCCCAATCCA TACATTAGGT 4020

AAGTATGCCC AAAAATGTCA TGCTTTTGCG AAGGCACTAC ATTACAAAGA GGTAGAATTC 4080

TTAGAAGAGC CGAAAAATTC AACAATCGAG GCATTGATTA GCATTAATAA TCAACTTCAC 4140

CAAACTGATT CTGCTATTGG TATTTTGAAG CATGCGCAAC AACACAATGA ATTGCAGCTG 4200

AAGGAAACTT GGTATGAAAA ACTTCAACGT TGGGAGGATG CTCTTGCAGC ATATAATGAG 4260

AAGGAGGCAG CAGGAGAAGA TTCGGTTGAA GTGATGATGG GAAAATTAAG ATCGTTATAT 4320

GCCCTTGGAG AGTGGGAAGA GCTTTCTAAA TTGGCATCTG AAAAGTGGGG CACGGCAAAA 4380

CCCGAAGTGA AGAAGGCAAT GGCGCCTTTG GCTGCCGGCG CTGCCTGGGG TTTGGAGCAA 4440

TGGGATGAAA TAGCCCAGTA TACTAGCGTC ATGAAATCGC AGTCTCCAGA TAAAGAATTC 4500

TATGATGCAA TTTTATGTTT GCATAGGAAT AATTTTAAGA AGGCGGAAGT TCACATCTTT 4560

AATGCAAGGG ATCTTCTAGT TACTGAATTG TCAGCTCTTG TTAATGAAAG CTACAATAGA 4620

GCATATAATG TTGTTGTTAG AGCGCAGATT ATAGCAGAGT TGGAGGAAAT CATCAAATAT 4680

AAGAAGTTGC CACAAAATTC AGATAAACGT CTAACTATGA GAGAAACTTG GAATACCAGA 4740

TTACTGGGCT GTCAAAAAAA TATTGATGTG TGGCAAAGAA TTCTGCGTGT CAGATCATTG 4800

GTGATAAAGC CAAAGGAGGA TGCTCAAGTG AGGATTAAGT TTGCCAACTT ATGCAGAAAA 4860

TCGGGTAGGA TGGCGCTAGC TAAAAAAGTC TTAAATACAT TGCTTGAAGA AACAGATGAC 4920

CCAGATCATC CTAATACTGC TAAGGCATCC CCTCCAGTTG TTTATGCACA ACTGAAGTAC 4980

TTGTGGGCTA CGGGGTTGCA AGATGAGGCT TTGAAGCAAT TAATTAATTT CACATCTAGA 5040

ATGGCTCATG ATTTAGGTTT GGATCCAAAT AATATGATAG CTCAAAGCGT TCCTCAACAA 5100

AGCAAAAGAG TCCCTCGTCA CGTTGAAGAT TATACTAAGC TTTTAGCTCG TTGTTTCTTG 5160

AAGCAAGGAG AATGGAGAGT TTGCTTACAG CCTAAATGGA GATTGAGCAA TCCAGATTCG 5220

ATCCTAGGCT CCTATTTGCT CGCTACACAT TTTGACAACA CATGGTACAA AGCGTGGCAT 5280

AACTGGGCAC TGGCCAATTT TGAAGTCATT TCTATGCTAA CATCTGTCTC TAAAAAGAAA 5340

CAGGAAGGAA GTGATGCTTC CTCGGTAACT GATATTAATG AGTTTGATAA TGGCATGATC 5400

GGCGTCAATA CATTTGATGC TAAGGAAGTT CATTACTCTT CTAATTTAAT ACACAGGCAC 5460

GTAATTCCAG CAATTAAGGG TTTTTTTCAT TCCATTTCTT TATCAGAATC AAGCTCTCTT 5520

CAAGATGCAT TAAGGTTATT AACTTTATGG TTTACTTTTG GTGGTATTCC AGAAGCAACC 5580

CAAGCTATGC ACGAGGGTTT CAACCTAATC CAAATAGGCA CATGGTTAGA AGTGTTGCCA 5640

CAGTTAATTT CTAGAATTCA TCAACCCAAT CAAATTGTTA GTAGGTCATT ACTCTCCCTA 5700

TTATCTGATC TAGGTAAGGC TCATCCGCAG GCATTAGTGT ACCCCTTAAT GGTTGCGATT 5760

AAATCCGAAT CTCTCTCACG ACAGAAAGCA GCTTTGTCCA TCATAGAAAA GATGAGAATA 5820

CATAGTCCAG TTTTGGTCGA CCAGGCTGAA CTTGTCAGCC ACGAATTGAT ACGTATGGCG 5880

GTGCTTTGGC ATGAGCAATG GTATGAGGGT CTGGATGACG CCAGTAGGCA GTTTTTTGGA 5940

GAACATAATA CCGAAAAAAT GTTTGCTGCT TTAGAGCCTC TGTACGAAAT GCTGAAGAGA 6000

GGACCGGAAA CTTTGAGGGA AATATCGTTC CAAAATTCTT TTGGTAGGGA CTTGAATGAC 6060

GCTTACGAAT GGCTGATGAA TTACAAAAAA TCTAAAGATG TTAGTAATTT AAACCAAGCG 6120

TGGGACATTT ACTATAATGT TTTCAGGAAA ATTGGTAAAC AGTTGCCACA ATTACAAACT 6180

CTTGAACTAC AACATGTGTC GCCAAAACTA CTATCTGCGC ATGATTTGGA ATTGGCTGTC 6240

CCCGGGACCC GTGCAAGTGG TGGAAAACCA ATTGTTAAAA TATCTAAATT CGAGCCAGTA 6300

TTTTCAGTAA TCTCATCCAA ACAAAGACCG AGAAAGTTTT GTATCAAGGG TAGTGATGGT 6360

AAAGATTATA AGTATGTGTT GAAAGGACAT GAAGACATTA GACAGGATAG CTTGGTCATG 6420

CAATTATTCG GACTAGTTAA CACGCTTTTG CAAAATGACG CTGAGTGCTT TAGAAGGCAT 6480

CTAGATATCC AGCAATATCC AGCAATCCCA TTATCTCCGA AGTCTGGGTT ACTGGGTTGG 6540

GTACCGAATA GTGACACGTT CCATGTATTA ATTAGGGAGC ATAGAGAAGC CAAAAAAATT 6600

CCTTTAAACA TTGAGCATTG GGTCATGTTA CAAATGGCAC CTGATTATGA CAATTTAACG 6660

TTGTTGCAGA AAGTAGAAGT CTTCACTTAC GCCCTAAATA ATACGGAGGG ACAAGATCTT 6720

TATAAGGTGT TATGGCTGAA GAGTAGGTCA TCGGAAACGT GGTTGGAGCG TAGAACTACT 6780

TACACTCGAT CGCTAGCCGT GATGTCCATG ACCGGTTATA TATTGGGGTT AGGTGACCGC 6840

CACCCTAGTA ATTTGATGTT GGATAGAATC ACTGGGAAAG TCATTCATAT TGATTTTGGT 6900

GATTGTTTCG AGGCTGCTAT ATTAAGAGAA AAATTCCCCG AAAAAGTACC TTTTAGATTA 6960

ACTAGAATGT TAACATATGC AATGGAAGTG AGTGGAATTG AAGGTAGCTT CCGTATTACT 7020

TGTGAGAATG TTATGAAGGT ACTTAGAGAT AACAAGGGTT CATTAATGGC AATCCTTGAA 7080

GCTTTTGCTT TCGATCCTTT GATCAATTGG GGTTTTGACT TACCAACAAA GAAAATTGAG 7140

GAAGAAACGG GCATTCAACT TCCCGTGATG AATGCCAATG AGCTATTGAG TAATGGGGCT 7200

ATTACCGAAG AAGAAGTTCA AAGGGTGGAA AACGAGCACA AGAATGCCAT TCGAAATGCA 7260

AGGGCCATGT TGGTATTGAA GCGCATTACT GACAAATTAA CGGGGAACGA TATAAGAAGG 7320

TTTAATGACT TGGACGTTCC AGAACAAGTG GATAAACTAA TCCAACAAGC CACATCAGTG 7380

GAAAACCTAT GCCAACATTA TATCGGTTGG TGTCCATTCT GGTAG 7425

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i +f++   +++skq+p+k +++Gsdgk y y +kg+eD rqd  v+qlf+lvNtlL++d

Q: 2094  ISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQND  2153

         67899*******************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e+ rr+L i++y  +pls++sgl++wv+n+++ + l+++ +e k++ l+        ++

Q: 2154  AECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLN-------IEH  2206

         *************************************************9.......999

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

           +  ++p+++ l+l   +evf  +l+n    + l k+l+ k+ s+e w+e+r+ ytrsl

Q: 2207  WVMLQMAPDYDNLTLLqkVEVFTYALNNTE-GQDLYKVLWLKSRSSETWLERRTTYTRSL  2265

         9999*******9998778**********55.579999***********************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238

         Av+s+ gyiLgLgdrh++nl++d+ tg+v+hidfg +fe a  ++k+pekvPFRLTr+++

Q: 2266  AVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLT  2325

         ************************************************************

S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk...kkktsketee  295

          a++v g+eG fr++ce+v++vlr++k +l++iLe+f  dpl++w     +kk ++et++

Q: 2326  YAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFdlpTKKIEEETGI  2385

         **********************************************85554444444444

S: 296   ela  298

+l

Q: 2386  QLP  2388

Domain Sequence
(FASTA)

ISKFEPVFSV ISSKQRPRKF CIKGSDGKDY KYVLKGHEDI RQDSLVMQLF GLVNTLLQND 60

AECFRRHLDI QQYPAIPLSP KSGLLGWVPN SDTFHVLIRE HREAKKIPLN IEHWVMLQMA 120

PDYDNLTLLQ KVEVFTYALN NTEGQDLYKV LWLKSRSSET WLERRTTYTR SLAVMSMTGY 180

ILGLGDRHPS NLMLDRITGK VIHIDFGDCF EAAILREKFP EKVPFRLTRM LTYAMEVSGI 240

EGSFRITCEN VMKVLRDNKG SLMAILEAFA FDPLINWGFD LPTKKIEEET GIQLP 295

Keyword

ATP-binding; Cell cycle; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Vacuole.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0031234	; C:extrinsic to internal side of plasma membrane
GO:0000329	; C:fungal-type vacuole membrane
GO:0005739	; C:mitochondrion
GO:0031931	; C:TORC1 complex
GO:0031932	; C:TORC2 complex
GO:0004430	; F:1-phosphatidylinositol 4-kinase activity
GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030037	; P:actin filament reorganization involved in cell cycle
GO:0030950	; P:establishment or maintenance of actin cytoskeleton polarity
GO:0000080	; P:G1 phase of mitotic cell cycle
GO:0010507	; P:negative regulation of autophagy
GO:0045807	; P:positive regulation of endocytosis
GO:0051726	; P:regulation of cell cycle
GO:0001558	; P:regulation of cell growth
GO:0007266	; P:Rho protein signal transduction
GO:0042254	; P:ribosome biogenesis
GO:0031929	; P:TOR signaling cascade

KEGG

sce:YKL203C

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR024585	; DUF3385_TOR.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF11865	; DUF3385; 1.
PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013