EPS-SAC-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Asp-Based PTP/FCP	161.7	4.5E-48	258	412	155

Status

Reviewed

Ensembl Protein

YLL010C

UniProt Accession

Q07800; D6VXZ2;

Protein Name

Phosphatase PSR1

Protein Synonyms/Alias

Plasma membrane sodium response protein 1;

Gene Name

PSR1

Gene Synonyms/Alias

PSR1; YLL010C; L1341;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YLL010C	YLL010C	YLL010C

Organism

Saccharomyces cerevisiae

Functional Description

Has phosphatase activity in vitro. Involved in theresponse to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.

Protein Length

427

Protein Sequence
(FASTA)

MGFISSILCC SSETTQSNSN SAYRQQQSSS LNKNRSVKHS NTKSRTRGVH QTNSPPSKTN 60

SAATFSSTER STGKSGISTN DNEKKKPSSP TAAVTATTTN NMTKVEKRIS KDDLYEEKYE 120

VDEDEEIDDE DNRRSRGIVQ EKGDAVKDTS RQKKQQQQQQ QQSQPQPQPQ SQSQSQSQSQ 180

SQQRGPTVQV SSDHLIQDMN LSRVSSSSQA SETSNDADDE DDEDEEYIDL TLLQQGQYHA 240

PGYNTLLPPQ DESTKGKKCL ILDLDETLVH SSFKYLRSAD FVLSVEIDDQ VHNVYVIKRP 300

GVEEFLERVG KLFEVVVFTA SVSRYGDPLL DILDTDKVIH HRLFREACYN YEGNYIKNLS 360

QIGRPLSDII ILDNSPASYI FHPQHAIPIS SWFSDTHDNE LLDIIPLLED LSVKTSLDVG 420

KILDVTI 427

Nucleotide Sequence
(FASTA)

ATGGGTTTCA TATCGTCAAT ACTGTGCTGC TCTTCCGAGA CGACACAATC CAATTCCAAT 60

TCTGCTTATC GCCAACAACA GAGCAGTTCT CTCAATAAAA ACAGAAGCGT TAAACATTCC 120

AACACGAAAA GCCGAACCCG TGGCGTACAT CAGACAAACT CTCCTCCTTC TAAGACAAAT 180

TCAGCCGCTA CTTTCAGTTC CACTGAACGA TCCACCGGTA AATCTGGGAT AAGCACGAAC 240

GATAATGAAA AAAAGAAGCC ATCGTCGCCG ACTGCAGCCG TCACCGCCAC TACTACTAAT 300

AATATGACAA AAGTAGAGAA GCGAATTAGT AAAGATGATC TTTACGAGGA AAAATACGAG 360

GTTGACGAAG ATGAAGAGAT CGACGATGAA GATAACCGTC GCAGTCGTGG CATTGTACAG 420

GAAAAAGGAG ATGCTGTGAA AGATACTTCC AGGCAGAAAA AACAACAGCA GCAACAACAA 480

CAACAGTCAC AACCACAACC ACAACCCCAG TCACAGTCAC AGTCACAGTC GCAGTCGCAG 540

TCGCAGCAGC GAGGGCCTAC TGTACAAGTA TCGTCTGACC ATCTTATCCA AGATATGAAT 600

TTGAGTAGGG TAAGTAGCAG CTCTCAAGCC AGTGAAACTT CCAACGATGC CGACGACGAA 660

GACGATGAAG ATGAAGAATA TATTGATCTA ACGCTTTTGC AGCAGGGCCA GTATCATGCA 720

CCAGGTTACA ACACTCTGCT CCCCCCACAA GATGAAAGTA CAAAGGGCAA GAAATGCCTA 780

ATACTGGACC TGGATGAAAC CTTGGTACAC TCTTCTTTCA AATACTTACG ATCTGCGGAT 840

TTTGTTTTGT CTGTGGAAAT AGATGACCAA GTACACAATG TCTATGTCAT TAAAAGACCT 900

GGTGTGGAAG AATTTTTGGA AAGAGTCGGA AAATTATTCG AGGTTGTAGT CTTCACGGCT 960

AGTGTCTCTC GATACGGTGA TCCTTTGCTT GATATATTAG ACACAGATAA AGTCATTCAT 1020

CACAGATTAT TCAGAGAGGC TTGCTATAAC TATGAAGGAA ACTATATAAA AAACTTATCC 1080

CAGATTGGAA GGCCGTTATC AGATATCATC ATTCTCGATA ACTCTCCGGC ATCTTATATT 1140

TTTCATCCCC AACATGCAAT ACCGATTTCG TCCTGGTTCT CAGATACTCA TGATAACGAA 1200

TTATTAGATA TTATTCCTCT TTTAGAAGAC CTTTCTGTGA AAACCTCACT GGATGTGGGC 1260

AAAATTTTGG ATGTAACAAT ATAA 1284

Domain Profile

S: 1     ktLVLDLDetLvhsksekde.e........e.ektkasvkkRPgldeFLkelskayevvi  50

         k+L+LDLDetLvhs++++            + + ++++v kRPg++eFL+++ k +evv+

Q: 258   KCLILDLDETLVHSSFKYLRsAdfvlsveiDdQVHNVYVIKRPGVEEFLERVGKLFEVVV  317

         8**************6555542577776652699**************************

S: 51    ftasskeyadavldkldpkkklfkkrlyresctlengkyvKdLsllgrdlskvvivDdsp  110

         ftas ++y d++ld+ld+  k++++rl+re c   +g+y+K+Ls +gr+ls+++i+D+sp

Q: 318   FTASVSRYGDPLLDILDT-DKVIHHRLFREACYNYEGNYIKNLSQIGRPLSDIIILDNSP  376

         *****************8.789**********98889***********************

S: 111   rsfelqpdnlipiepfygdsdkdtellkllpfleale  147

          s+ ++p+++ipi+++++d  +d+ell+++p+le+l+

Q: 377   ASYIFHPQHAIPISSWFSD-THDNELLDIIPLLEDLS  412

         *******************.999**********9887

Domain Sequence
(FASTA)

KCLILDLDET LVHSSFKYLR SADFVLSVEI DDQVHNVYVI KRPGVEEFLE RVGKLFEVVV 60

FTASVSRYGD PLLDILDTDK VIHHRLFREA CYNYEGNYIK NLSQIGRPLS DIIILDNSPA 120

SYIFHPQHAI PISSWFSDTH DNELLDIIPL LEDLS 155

Keyword

Cell membrane; Complete proteome; Hydrolase; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>