EPS-SAC-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	374.9	3.1E-113	113	320	208

Status

Reviewed

Ensembl Protein

YLR433C

UniProt Accession

P23287; D6VZ68;

Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit A1

Protein Synonyms/Alias

Calcineurin A1; Calmodulin-binding protein 1;

Gene Name

CNA1

Gene Synonyms/Alias

CNA1; CMP1; YLR433C; L9753.6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YLR433C	YLR433C	YLR433C

Organism

Saccharomyces cerevisiae

Functional Description

Calcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Protein Length

553

Protein Sequence
(FASTA)

MSKDLNSSRI KIIKPNDSYI KVDRKKDLTK YELENGKVIS TKDRPIASVP AITGKIPSDE 60

EVFDSKTGLP NHSFLREHFF HEGRLSKEQA IKILNMSTVA LSKEPNLLKL KAPITICGDI 120

HGQYYDLLKL FEVGGDPAEI DYLFLGDYVD RGAFSFECLI YLYSLKLNNL GRFWMLRGNH 180

ECKHLTSYFT FKNEMLHKYD MEVYDACCRS FNVLPLAALM NGQYFCVHGG ISPELKSVED 240

VNKINRFREI PSRGLMCDLL WADPVENYDD ARDGSEFDQS EDEFVPNSLR GCSFAFTFKA 300

SCKFLKANGL LSIIRAHEAQ DAGYRMYKNN KVTGFPSLIT MFSAPNYLDT YHNKAAVLKY 360

EENVMNIRQF HMSPHPYWLP DFMDVFTWSL PFVGEKVTSM LVSILNICSE QELDPESEPK 420

AAEETVKARA NATKETGTPS DEKASSAILE DETRRKALRN KILAIAKVSR MFSVLREESE 480

KVEYLKTMNA GVLPRGALAR GTEGLNETLS TFEKARKEDL INEKLPPSLS EVEQEKIKYY 540

EKILKGAEKK PQL 553

Nucleotide Sequence
(FASTA)

ATGTCGAAAG ACTTGAATTC TTCACGCATC AAAATCATTA AACCTAATGA CTCTTACATA 60

AAGGTTGACC GGAAAAAAGA TTTAACAAAA TACGAATTAG AAAACGGTAA AGTAATTTCT 120

ACTAAGGACC GACCTATCGC TTCTGTACCT GCCATAACAG GAAAGATACC AAGTGATGAG 180

GAAGTATTCG ACTCCAAGAC GGGATTACCT AATCATTCCT TTTTAAGAGA GCATTTCTTT 240

CATGAGGGTC GACTTTCTAA GGAACAGGCC ATAAAAATCT TAAATATGTC AACTGTAGCA 300

TTGAGTAAAG AACCCAATCT ACTAAAACTC AAAGCGCCAA TTACTATATG TGGTGATATT 360

CACGGGCAGT ATTATGATTT ATTGAAACTG TTTGAAGTTG GCGGTGACCC CGCCGAAATC 420

GACTATTTAT TCTTGGGGGA TTATGTTGAT AGAGGTGCAT TCTCTTTTGA GTGTCTGATT 480

TATTTGTACT CCTTGAAGTT GAATAATTTA GGGAGATTTT GGATGCTAAG AGGTAACCAT 540

GAGTGTAAGC ACTTGACCTC TTATTTTACT TTTAAGAATG AGATGTTGCA CAAATACGAT 600

ATGGAAGTTT ACGATGCTTG CTGCAGATCA TTCAATGTCT TACCATTAGC AGCTTTAATG 660

AACGGACAAT ATTTTTGTGT GCATGGTGGT ATCTCTCCAG AGTTAAAATC AGTAGAGGAT 720

GTTAATAAAA TTAATAGATT TCGAGAAATC CCATCTCGTG GTCTCATGTG TGACCTACTA 780

TGGGCCGATC CTGTCGAAAA TTATGATGAT GCAAGAGATG GTAGCGAATT TGATCAGAGC 840

GAGGATGAAT TCGTACCTAA CAGTTTGAGG GGTTGCTCTT TCGCCTTCAC TTTTAAAGCA 900

TCATGCAAGT TTTTGAAGGC AAATGGTTTG TTATCTATTA TTAGAGCACA CGAAGCACAG 960

GATGCTGGGT ACAGAATGTA TAAAAACAAT AAAGTAACAG GCTTCCCGAG CTTAATAACC 1020

ATGTTCAGTG CGCCAAACTA CCTGGACACA TATCATAATA AAGCTGCTGT GTTAAAATAT 1080

GAAGAAAACG TCATGAACAT CAGGCAGTTT CACATGTCTC CGCACCCTTA CTGGTTGCCT 1140

GATTTTATGG ATGTTTTCAC CTGGTCACTA CCTTTTGTTG GCGAAAAAGT TACTAGCATG 1200

TTAGTGTCTA TATTAAACAT ATGTAGTGAG CAGGAACTTG ACCCAGAATC GGAACCCAAA 1260

GCTGCGGAGG AGACTGTAAA GGCAAGAGCA AACGCAACTA AGGAGACCGG CACCCCATCT 1320

GATGAAAAGG CGTCATCAGC GATATTAGAA GATGAAACCC GAAGAAAGGC TTTGAGAAAT 1380

AAGATATTAG CTATTGCTAA AGTTTCAAGA ATGTTTTCGG TGCTAAGAGA AGAGAGCGAA 1440

AAAGTGGAAT ATTTGAAAAC TATGAATGCC GGTGTCTTAC CTCGTGGTGC TCTAGCTCGT 1500

GGGACTGAAG GTTTGAATGA AACGCTAAGC ACTTTTGAAA AGGCTAGAAA GGAAGACCTT 1560

ATTAATGAAA AATTACCACC ATCTTTATCG GAGGTTGAAC AAGAGAAGAT TAAATACTAC 1620

GAAAAAATAT TAAAGGGAGC GGAGAAAAAG CCACAACTGT GA 1662

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         p+t+cgdihgq++dllklfevgg+pa+++ylflgdyvdrg+fs+ec++yly+lk+++  +

Q: 113   PITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGR  172

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         +++lrgnhec+hlt+yftfk+e+++ky+++vydac+++f++lplaal+n+q++cvhgg+s

Q: 173   FWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGIS  232

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgn.......ekseeefvhnsvrgc  173

         pelk+++d++k++rf+e+p++glmcdllw+dp+e++++       ++se+efv+ns+rgc

Q: 233   PELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDDardgsefDQSEDEFVPNSLRGC  292

         *********************************************9**************

S: 174   syfysykavceflqennllsiiraheaq  201

         s+++++ka+c+fl++n+llsiiraheaq

Q: 293   SFAFTFKASCKFLKANGLLSIIRAHEAQ  320

         ***************************8

Domain Sequence
(FASTA)

PITICGDIHG QYYDLLKLFE VGGDPAEIDY LFLGDYVDRG AFSFECLIYL YSLKLNNLGR 60

FWMLRGNHEC KHLTSYFTFK NEMLHKYDME VYDACCRSFN VLPLAALMNG QYFCVHGGIS 120

PELKSVEDVN KINRFREIPS RGLMCDLLWA DPVENYDDAR DGSEFDQSED EFVPNSLRGC 180

SFAFTFKASC KFLKANGLLS IIRAHEAQ 208

Keyword

3D-structure; Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005737	; C:cytoplasm
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0000754	; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
GO:0006873	; P:cellular ion homeostasis
GO:0031505	; P:fungal-type cell wall organization

KEGG

sce:YLR433C

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013