EPS-SAC-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	381.9	2.2E-115	138	362	225

Status

Reviewed

Ensembl Protein

YML057W

UniProt Accession

P14747; D6VZB7;

Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit A2

Protein Synonyms/Alias

Calcineurin A2; Calmodulin-binding protein 2;

Gene Name

CMP2

Gene Synonyms/Alias

CMP2; CNA2; YML057W; YM9958.05;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YML057W	YML057W	YML057W

Organism

Saccharomyces cerevisiae

Functional Description

Calcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Protein Length

604

Protein Sequence
(FASTA)

MSSDAIRNTE QINAAIKIIE NKTERPQSST TPIDSKASTV AAANSTATET SRDLTQYTLD 60

DGRVVSTNRR IMNKVPAITS HVPTDEELFQ PNGIPRHEFL RDHFKREGKL SAAQAARIVT 120

LATELFSKEP NLISVPAPIT VCGDIHGQYF DLLKLFEVGG DPATTSYLFL GDYVDRGSFS 180

FECLIYLYSL KLNFNDHFWL LRGNHECKHL TSYFTFKNEM LHKYNLDIYE KCCESFNNLP 240

LAALMNGQYL CVHGGISPEL NSLQDINNLN RFREIPSHGL MCDLLWADPI EEYDEVLDKD 300

LTEEDIVNSK TMVPHHGKMA PSRDMFVPNS VRGCSYAFTY RAACHFLQET GLLSIIRAHE 360

AQDAGYRMYK NTKTLGFPSL LTLFSAPNYL DTYNNKAAIL KYENNVMNIR QFNMTPHPYW 420

LPDFMDVFTW SLPFVGEKVT EMLVAILNIC TEDELENDTP VIEELVGTDK KLPQAGKSEA 480

TPQPATSASP KHASILDDEH RRKALRNKIL AVAKVSRMYS VLREETNKVQ FLKDHNSGVL 540

PRGALSNGVK GLDEALSTFE RARKHDLINE KLPPSLDELK NENKKYYEKV WQKVHEHDAK 600

NDSK 604

Nucleotide Sequence
(FASTA)

ATGTCTTCAG ACGCTATAAG AAATACTGAG CAGATAAACG CCGCTATTAA AATTATAGAA 60

AACAAAACAG AGCGTCCGCA ATCGTCCACA ACCCCTATAG ATTCGAAGGC TAGTACAGTT 120

GCTGCTGCTA ATTCCACGGC CACAGAAACT TCCAGAGACC TTACACAATA TACCCTAGAT 180

GACGGAAGAG TCGTATCGAC AAACCGCAGA ATAATGAATA AAGTGCCCGC CATCACGTCA 240

CATGTTCCTA CAGATGAAGA GCTGTTCCAG CCCAATGGGA TACCTCGTCA CGAATTCCTA 300

AGAGATCATT TCAAGCGCGA GGGCAAATTG TCGGCTGCGC AGGCGGCCAG GATCGTTACA 360

CTTGCAACGG AACTCTTCAG CAAAGAACCC AACCTTATAT CTGTTCCCGC CCCAATCACA 420

GTTTGCGGTG ATATCCATGG CCAGTACTTT GACCTTTTGA AGCTATTCGA AGTTGGCGGA 480

GATCCGGCCA CTACATCGTA TTTGTTCTTG GGAGACTATG TCGACAGAGG GTCCTTTTCG 540

TTTGAGTGTC TTATTTATTT ATATTCTTTG AAGCTGAATT TTAACGACCA TTTCTGGCTA 600

CTGAGGGGTA ACCACGAATG TAAGCATCTA ACGTCATATT TCACTTTCAA AAATGAAATG 660

CTGCACAAGT ACAATCTAGA TATTTACGAG AAATGCTGCG AATCGTTTAA CAACTTGCCC 720

CTGGCTGCGT TAATGAACGG ACAGTATCTT TGTGTTCATG GTGGTATATC TCCCGAGTTA 780

AACTCTTTAC AGGACATTAA CAACCTAAAT AGATTCAGGG AGATTCCCTC TCATGGCCTG 840

ATGTGTGATC TGTTGTGGGC TGACCCGATT GAAGAGTACG ACGAAGTCTT GGATAAAGAC 900

TTGACTGAGG AAGACATAGT GAACTCCAAA ACCATGGTTC CTCATCATGG CAAGATGGCA 960

CCTTCAAGGG ATATGTTTGT CCCAAACTCA GTAAGGGGCT GTTCATATGC CTTCACGTAT 1020

CGTGCTGCGT GCCATTTTCT GCAAGAGACT GGCCTGTTGT CCATCATCAG GGCACACGAG 1080

GCTCAAGACG CTGGTTATAG AATGTACAAA AATACCAAGA CTTTGGGCTT TCCCTCTCTT 1140

TTGACCCTTT TCAGTGCGCC TAACTACTTG GACACCTACA ATAATAAGGC TGCCATATTG 1200

AAATACGAAA ATAATGTTAT GAATATCAGA CAATTCAACA TGACTCCACA CCCCTATTGG 1260

TTACCAGATT TCATGGACGT TTTCACGTGG TCCTTGCCAT TTGTTGGTGA AAAAGTTACA 1320

GAGATGCTTG TCGCAATTCT AAACATCTGT ACTGAAGATG AGCTGGAAAA CGACACCCCC 1380

GTCATTGAAG AATTAGTTGG TACCGATAAA AAATTGCCAC AAGCTGGTAA GTCGGAAGCA 1440

ACTCCACAAC CAGCCACTTC GGCGTCGCCT AAACATGCTT CCATTTTAGA TGACGAACAT 1500

CGAAGGAAAG CCTTACGAAA TAAGATTCTG GCCGTCGCCA AAGTTTCCAG AATGTATTCT 1560

GTTCTCAGAG AAGAAACCAA TAAAGTTCAG TTTTTAAAAG ATCACAATTC AGGCGTGTTG 1620

CCACGTGGCG CTTTATCTAA TGGTGTAAAG GGTTTAGATG AAGCCCTGTC TACCTTTGAA 1680

AGGGCAAGAA AGCACGATTT AATTAATGAA AAATTACCGC CTTCACTAGA CGAACTGAAA 1740

AACGAAAATA AGAAGTACTA CGAAAAAGTT TGGCAGAAAG TACATGAACA TGATGCAAAG 1800

AATGATAGCA AATAG 1815

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         p+tvcgdihgq+fdllklfevgg+pa+t+ylflgdyvdrg+fs+ec++yly+lk++++++

Q: 138   PITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDH  197

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         ++llrgnhec+hlt+yftfk+e+++ky+ ++y++c+e+f++lplaal+n+q+lcvhgg+s

Q: 198   FWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGIS  257

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgn......................  158

         pel++l+di++l+rf+e+p++glmcdllw+dp+e++++

Q: 258   PELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEvldkdlteedivnsktmvphhg  317

         ************************************************************

S: 159   ..ekseeefvhnsvrgcsyfysykavceflqennllsiiraheaq  201

           + s+++fv+nsvrgcsy+++y+a+c+flqe++llsiiraheaq

Q: 318   kmAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQ  362

         *99*****************************************8

Domain Sequence
(FASTA)

PITVCGDIHG QYFDLLKLFE VGGDPATTSY LFLGDYVDRG SFSFECLIYL YSLKLNFNDH 60

FWLLRGNHEC KHLTSYFTFK NEMLHKYNLD IYEKCCESFN NLPLAALMNG QYLCVHGGIS 120

PELNSLQDIN NLNRFREIPS HGLMCDLLWA DPIEEYDEVL DKDLTEEDIV NSKTMVPHHG 180

KMAPSRDMFV PNSVRGCSYA FTYRAACHFL QETGLLSIIR AHEAQ 225

Keyword

Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005737	; C:cytoplasm
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0000754	; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
GO:0006873	; P:cellular ion homeostasis

KEGG

sce:YML057W

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013