EKS-SAC-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK370.91.1E-11182337256
StatusReviewed
Ensembl ProteinYMR001C
UniProt AccessionP32562; D6VZH5;
Protein NameCell cycle serine/threonine-protein kinase CDC5/MSD2
Protein Synonyms/Alias
Gene NameCDC5
Gene Synonyms/Alias CDC5; MSD2, PKX2; YMR001C; YM8270.03C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YMR001CYMR001CYMR001C
OrganismSaccharomyces cerevisiae
Functional DescriptionProtein kinase required for the cell cycle where it isinvolved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.
Protein Length705
Protein Sequence
(FASTA)
MSLGPLKAIN DKQLNTRSKL VHTPIKGNTA DLVGKENHFK QTKRLDPNND HHHQPAQKKK 60
REKLSALCKT PPSLIKTRGK DYHRGHFLGE GGFARCFQIK DDSGEIFAAK TVAKASIKSE 120
KTRKKLLSEI QIHKSMSHPN IVQFIDCFED DSNVYILLEI CPNGSLMELL KRRKVLTEPE 180
VRFFTTQICG AIKYMHSRRV IHRDLKLGNI FFDSNYNLKI GDFGLAAVLA NESERKYTIC 240
GTPNYIAPEV LMGKHSGHSF EVDIWSLGVM LYALLIGKPP FQARDVNTIY ERIKCRDFSF 300
PRDKPISDEG KILIRDILSL DPIERPSLTE IMDYVWFRGT FPPSIPSTVM SEAPNFEDIP 360
EEQSLVNFKD CMEKSLLLES MSSDKIQRQK RDYISSIKSS IDKLEEYHQN RPFLPHSLSP 420
GGTKQKYKEV VDIEAQRRLN DLAREARIRR AQQAVLRKEL IATSTNVIKS EISLRILASE 480
CHLTLNGIVE AEAQYKMGGL PKSRLPKIKH PMIVTKWVDY SNKHGFSYQL STEDIGVLFN 540
NGTTVLRLAD AEEFWYISYD DREGWVASHY LLSEKPRELS RHLEVVDFFA KYMKANLSRV 600
STFGREEYHK DDVFLRRYTR YKPFVMFELS DGTFQFNFKD HHKMAISDGG KLVTYISPSH 660
ESTTYPLVEV LKYGEIPGYP ESNFREKLTL IKEGLKQKST IVTVD 705
Nucleotide Sequence
(FASTA)
ATGTCGTTGG GTCCTCTTAA AGCTATCAAT GATAAGCAAT TGAATACCCG TTCCAAGTTA 60
GTTCACACCC CAATAAAGGG AAATACCGCA GACCTCGTAG GAAAAGAAAA TCACTTTAAA 120
CAAACAAAGA GACTAGATCC GAATAATGAT CATCACCACC AGCCAGCTCA AAAAAAGAAA 180
AGGGAAAAGT TATCAGCTTT GTGTAAAACA CCACCTTCAT TAATCAAAAC AAGAGGAAAA 240
GACTATCACC GAGGTCATTT TTTAGGTGAA GGTGGATTTG CTCGCTGTTT CCAAATTAAG 300
GACGATTCAG GCGAAATTTT TGCTGCCAAA ACAGTTGCTA AAGCCTCAAT TAAATCAGAG 360
AAGACAAGAA AAAAGTTGTT GTCGGAGATT CAAATTCATA AAAGTATGTC CCATCCAAAT 420
ATCGTTCAGT TTATTGATTG TTTTGAGGAT GATAGCAATG TCTATATCTT ATTGGAGATA 480
TGCCCCAACG GTTCATTAAT GGAATTACTA AAAAGAAGAA AAGTTTTAAC AGAACCAGAA 540
GTTAGATTTT TCACCACTCA AATATGTGGT GCAATTAAGT ATATGCATTC AAGAAGAGTT 600
ATACATAGAG ATTTAAAACT TGGTAACATC TTCTTCGATT CAAACTATAA CTTAAAGATT 660
GGTGACTTCG GTCTGGCAGC TGTGTTGGCG AATGAAAGTG AACGTAAATA CACCATATGC 720
GGAACACCTA ATTACATCGC ACCTGAAGTG TTGATGGGTA AGCATTCTGG ACATTCATTT 780
GAAGTAGATA TTTGGTCATT AGGTGTTATG CTTTATGCTT TGTTGATTGG TAAGCCACCC 840
TTCCAAGCAA GAGATGTAAA CACTATTTAT GAAAGAATCA AATGTCGTGA TTTTTCGTTT 900
CCAAGAGATA AACCAATCTC AGATGAAGGT AAGATTTTAA TAAGAGACAT TCTATCCTTA 960
GATCCAATAG AAAGGCCCTC TTTGACTGAA ATTATGGATT ATGTATGGTT TAGGGGAACT 1020
TTCCCACCAT CTATTCCTTC GACGGTCATG TCAGAAGCAC CAAATTTTGA GGATATTCCT 1080
GAAGAGCAGT CACTGGTTAA CTTCAAAGAT TGCATGGAAA AATCTCTACT ATTAGAAAGC 1140
ATGAGCAGCG ATAAAATTCA GCGTCAAAAG AGGGATTATA TTTCTTCAAT TAAATCTAGT 1200
ATCGATAAAC TAGAAGAGTA CCACCAAAAC AGACCATTTT TACCACATTC TTTATCCCCT 1260
GGCGGGACGA AACAGAAATA TAAGGAGGTT GTTGATATAG AGGCACAAAG AAGATTAAAC 1320
GATTTGGCTC GTGAAGCAAG GATACGTAGA GCACAACAGG CCGTTTTGAG AAAAGAATTA 1380
ATAGCTACAT CGACCAATGT CATTAAATCA GAAATCTCCT TGAGAATATT AGCCAGTGAG 1440
TGTCATCTTA CTTTGAATGG CATTGTAGAA GCAGAAGCTC AGTATAAAAT GGGAGGTCTT 1500
CCGAAATCAA GATTGCCTAA AATTAAACAC CCAATGATAG TTACCAAGTG GGTCGACTAC 1560
TCCAACAAAC ACGGATTCTC CTATCAGTTA TCAACAGAGG ATATTGGTGT CTTATTTAAT 1620
AATGGCACCA CAGTTCTCCG ATTGGCAGAT GCAGAAGAGT TTTGGTATAT TAGTTATGAC 1680
GATCGGGAAG GTTGGGTAGC AAGTCATTAT TTATTGAGCG AAAAACCACG AGAGCTAAGT 1740
AGACATTTAG AAGTAGTTGA TTTTTTTGCC AAGTACATGA AGGCAAATTT GAGCCGAGTA 1800
TCTACGTTTG GCAGAGAAGA ATATCATAAA GATGATGTAT TTTTGAGAAG ATACACAAGG 1860
TATAAACCAT TTGTTATGTT TGAACTAAGT GATGGTACTT TCCAGTTCAA TTTCAAAGAT 1920
CATCATAAAA TGGCAATATC CGACGGAGGT AAATTGGTGA CCTACATTTC TCCCTCCCAT 1980
GAAAGCACCA CATATCCCTT AGTTGAAGTA CTAAAATATG GCGAGATCCC AGGATATCCA 2040
GAAAGTAACT TTAGAGAGAA ACTAACTTTG ATAAAGGAAG GTTTGAAGCA GAAGTCCACA 2100
ATTGTTACCG TAGATTAA 2118
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+rg++lG+Ggfa+c+++kd +++e+fa+k+v+k+++++ek+r+k+ +ei+ih+s++h+n
Q: 82    YHRGHFLGEGGFARCFQIKD-DSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPN  140
         99*****************9.99*************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         iv+++++fed++nvy++le+c ++sl+ellkrrk+ltepevr++++qi+ ++ky+h++r+
Q: 141   IVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRV  200
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevl..skkghsl  178
         +hrdlklgn+f+++++++kigdfGla+ l++e+erk+t+cGtPnyiaPevl  +++ghs+
Q: 201   IHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLmgKHSGHSF  260
         ***************************************************8889*****
S: 179   evdiWslGcilytllvGkPPfetkelketyekikkaeyslPss..lskeaksliakllkk  236
         evdiWslG++ly+ll+GkPPf++++++++ye+ik++++s+P++  +s+e+k li+++l+ 
Q: 261   EVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDkpISDEGKILIRDILSL  320
         *****************************************98789**************
S: 237   ePeerpsleevlkdefl  253
         +P erpsl+e++++ ++
Q: 321   DPIERPSLTEIMDYVWF  337
         *************9987
Domain Sequence
(FASTA)
YHRGHFLGEG GFARCFQIKD DSGEIFAAKT VAKASIKSEK TRKKLLSEIQ IHKSMSHPNI 60
VQFIDCFEDD SNVYILLEIC PNGSLMELLK RRKVLTEPEV RFFTTQICGA IKYMHSRRVI 120
HRDLKLGNIF FDSNYNLKIG DFGLAAVLAN ESERKYTICG TPNYIAPEVL MGKHSGHSFE 180
VDIWSLGVML YALLIGKPPF QARDVNTIYE RIKCRDFSFP RDKPISDEGK ILIRDILSLD 240
PIERPSLTEI MDYVWF 256
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Mitosis; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00243
EKS-ANC-00251
EKS-BOT-00260
EKS-CAE-00236
EKS-CAJ-00268
EKS-CAF-00267
EKS-CAP-00295
EKS-CHH-00011
EKS-CII-00157
EKS-CIS-00035
EKS-DAR-00595
EKS-DAN-00009
EKS-DIO-00019
EKS-DRM-00134
EKS-ECT-00011
EKS-EQC-00252
EKS-FEC-00246
EKS-GAM-00161
EKS-GAG-00218
EKS-GAA-00322
EKS-GOG-00258
EKS-HOS-00267
EKS-ICT-00245
EKS-LAC-00274
EKS-LOA-00270
EKS-MAM-00262
EKS-MAE-00013
EKS-MEG-00206
EKS-MIM-00016
EKS-MOD-00259
EKS-MUM-00291
EKS-MUP-00258
EKS-MYL-00263
EKS-NOL-00241
EKS-ORN-00340
EKS-ORA-00229
EKS-ORC-00246
EKS-ORL-00317
EKS-OTG-00266
EKS-PAT-00248
EKS-PES-00232
EKS-PEM-00136
EKS-POA-00253
EKS-PRC-00018
EKS-PTV-00033
EKS-RAN-00275
EKS-SAH-00246
EKS-SUS-00226
EKS-TAG-00276
EKS-TAR-00335
EKS-TEN-00331
EKS-TUB-00014
EKS-TUT-00029
EKS-VIP-00009
EKS-XET-00335
EKS-XIM-00332
EKS-SCP-00027
Gene Ontology
GO:0005935; C:cellular bud neck
GO:0005634; C:nucleus
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0051301; P:cell division
GO:0007067; P:mitosis
GO:0010696; P:positive regulation of spindle pole body separation
GO:0000712; P:resolution of meiotic recombination intermediates
GO:0090306; P:spindle assembly involved in meiosis
GO:0070194; P:synaptonemal complex disassembly
KEGG
sce:YMR001C;
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013