EKS-SAC-00046
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00046
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt433.21.2E-130344599256
StatusReviewed
Ensembl ProteinYMR104C
UniProt AccessionP18961; D6VZS6;
Protein NameSerine/threonine-protein kinase YPK2/YKR2
Protein Synonyms/Alias
Gene NameYPK2
Gene Synonyms/Alias YPK2; YKR2; YMR104C; YM9718.03C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YMR104CYMR104CYMR104C
OrganismSaccharomyces cerevisiae
Functional DescriptionMay act as a downstream kinase in the sphingolipid-mediated signaling pathway. Plays an essential role in the proliferation of yeast cells. Involved in a signaling pathway, required for optimal cell wall integrity, that acts in parallel with the PKC1-SLT2-dependent pathway. A substrate of TOR complex 2 (TORC2) and required for TORC2 to regulate spatial aspects of cell growth. Phosphorylation of residue Thr-501 is indispensable for function.
Protein Length677
Protein Sequence
(FASTA)
MHSWRISKFK LGRSKEDDGS SEDENEKSWG NGLFHFHHGE KHHDGSPKNH NHEHEHHIRK 60
INTNETLPSS LSSPKLRNDA SFKNPSGIGN DNSKASERKA SQSSTETQGP SSESGLMTVK 120
VYSGKDFTLP FPITSNSTIL QKLLSSGILT SSSNDASEVA AIMRQLPRYK RVDQDSAGEG 180
LIDRAFATKF IPSSILLPGS TNSSPLLYFT IEFDNSITTI SPDMGTMEQP VFNKISTFDV 240
TRKLRFLKID VFARIPSLLL PSKNWQQEIG EQDEVLKEIL KKINTNQDIH LDSFHLPLNL 300
KIDSAAQIRL YNHHWISLER GYGKLNITVD YKPSKNKPLS IDDFDLLKVI GKGSFGKVMQ 360
VRKKDTQKIY ALKALRKAYI VSKCEVTHTL AERTVLARVD CPFIVPLKFS FQSPEKLYLV 420
LAFINGGELF YHLQHEGRFS LARSRFYIAE LLCALDSLHK LDVIYRDLKP ENILLDYQGH 480
IALCDFGLCK LNMKDNDKTD TFCGTPEYLA PEILLGQGYT KTVDWWTLGI LLYEMMTGLP 540
PYYDENVPVM YKKILQQPLL FPDGFDPAAK DLLIGLLSRD PSRRLGVNGT DEIRNHPFFK 600
DISWKKLLLK GYIPPYKPIV KSEIDTANFD QEFTKEKPID SVVDEYLSAS IQKQFGGWTY 660
IGDEQLGDSP SQGRSIS 677
Nucleotide Sequence
(FASTA)
ATGCATTCCT GGCGAATATC CAAGTTTAAG TTAGGAAGGT CCAAAGAAGA TGATGGGAGT 60
AGTGAAGATG AAAATGAAAA ATCGTGGGGT AATGGCCTGT TTCATTTCCA CCATGGAGAA 120
AAACATCACG ATGGTAGCCC GAAGAATCAT AATCATGAAC ACGAACACCA TATAAGAAAG 180
ATCAATACAA ATGAGACTCT CCCAAGTTCC TTAAGTTCTC CAAAATTACG TAATGATGCA 240
TCCTTCAAGA ATCCATCGGG GATAGGAAAT GACAATTCTA AGGCTTCCGA AAGGAAAGCT 300
AGTCAGTCGT CTACTGAGAC GCAGGGACCG AGTTCGGAAT CCGGACTAAT GACAGTGAAG 360
GTGTATTCTG GTAAAGATTT TACTCTTCCC TTCCCTATCA CCTCTAACTC TACTATTTTA 420
CAAAAACTAC TAAGTTCCGG CATCCTTACT TCATCATCCA ATGACGCTTC CGAAGTTGCA 480
GCCATAATGC GGCAGCTACC ACGATACAAG AGAGTGGATC AAGATTCAGC AGGGGAAGGC 540
TTGATAGATA GAGCTTTTGC CACTAAATTC ATTCCTTCCT CTATATTGTT ACCTGGGTCA 600
ACAAATTCAA GCCCATTACT TTATTTTACA ATTGAATTTG ATAATTCTAT TACTACTATT 660
AGTCCAGATA TGGGAACGAT GGAGCAACCA GTGTTTAACA AAATATCGAC ATTTGATGTA 720
ACAAGAAAAT TACGATTTTT AAAAATCGAT GTCTTTGCAA GGATTCCATC CCTACTTTTA 780
CCCTCTAAAA ACTGGCAACA GGAGATTGGC GAGCAGGACG AAGTACTGAA GGAGATTTTA 840
AAAAAAATCA ATACAAATCA GGATATCCAT TTGGACTCCT TCCATTTACC TTTGAATTTA 900
AAAATCGATT CTGCAGCCCA AATAAGACTA TACAATCACC ATTGGATTTC TTTAGAAAGG 960
GGATATGGTA AATTAAATAT CACGGTGGAC TACAAACCTT CTAAGAACAA GCCTCTCTCC 1020
ATTGATGACT TTGATCTATT GAAGGTTATC GGGAAGGGTT CGTTCGGCAA AGTGATGCAA 1080
GTAAGGAAAA AAGATACCCA AAAGATTTAC GCTTTGAAGG CTCTGAGAAA AGCATATATT 1140
GTATCGAAAT GTGAAGTGAC ACATACTTTA GCGGAGAGGA CTGTCCTAGC AAGAGTTGAC 1200
TGCCCCTTTA TTGTTCCGTT GAAGTTCTCA TTCCAATCTC CGGAGAAGTT GTACCTAGTA 1260
TTAGCTTTCA TTAATGGCGG TGAACTGTTC TACCATTTAC AACACGAGGG ACGATTCAGT 1320
CTAGCACGCT CCCGTTTTTA TATTGCAGAA CTATTATGTG CTCTCGATTC ATTACACAAA 1380
CTTGACGTCA TTTATCGTGA CCTAAAGCCT GAAAACATTC TATTGGATTA CCAAGGACAT 1440
ATTGCACTGT GTGATTTTGG GCTTTGCAAG CTGAACATGA AGGATAATGA CAAAACAGAC 1500
ACTTTCTGTG GTACTCCCGA ATATTTGGCA CCAGAAATCT TGTTGGGGCA GGGCTATACT 1560
AAAACAGTTG ACTGGTGGAC ATTAGGTATC TTACTGTATG AGATGATGAC AGGGCTGCCA 1620
CCATACTATG ATGAGAACGT TCCTGTTATG TACAAGAAAA TTCTGCAGCA ACCGCTACTA 1680
TTTCCTGATG GATTTGACCC TGCGGCAAAA GACCTATTAA TTGGCCTCTT AAGCAGAGAC 1740
CCAAGCAGAA GACTCGGCGT TAACGGTACA GATGAAATTC GTAACCATCC TTTCTTTAAA 1800
GACATCTCAT GGAAAAAGCT ACTTTTGAAG GGCTATATTC CGCCTTACAA GCCAATTGTA 1860
AAGAGTGAAA TAGATACTGC AAATTTTGAT CAAGAGTTCA CTAAGGAAAA ACCGATCGAT 1920
AGTGTAGTGG ACGAGTACTT AAGTGCAAGT ATTCAAAAGC AGTTTGGTGG GTGGACGTAC 1980
ATTGGTGACG AACAGTTGGG TGATTCTCCT TCGCAGGGGA GAAGCATTAG TTAG 2034
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         fdllk++GkG+fGkv++vr+k+tqk+yalk+l+k++iv+k+ev+htl+er+vl+r+++pf
Q: 344   FDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPF  403
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120
         +v lk+sfq++ekl+lvl+++nGGelf+hl++e++fs +r+rfy+ae+++ald+lh+ dv
Q: 404   IVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDV  463
         ************************************************************
S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180
         +yrdlk+en+lld++Ghi+++dfGlck ++kd+dkt+tfcGtpeylape+l +++y+k+v
Q: 464   IYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTV  523
         ************************************************************
S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240
         dww+lG++lyem++G++p+y+++++ ++++il+++l fp+ +++ ak+ll+Gll++dp++
Q: 524   DWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSR  583
         ************************************************************
S: 241   rlGggkddakeireheff  258
         rlG  +++++eir+h+ff
Q: 584   RLG--VNGTDEIRNHPFF  599
         **9..7***********9
Domain Sequence
(FASTA)
FDLLKVIGKG SFGKVMQVRK KDTQKIYALK ALRKAYIVSK CEVTHTLAER TVLARVDCPF 60
IVPLKFSFQS PEKLYLVLAF INGGELFYHL QHEGRFSLAR SRFYIAELLC ALDSLHKLDV 120
IYRDLKPENI LLDYQGHIAL CDFGLCKLNM KDNDKTDTFC GTPEYLAPEI LLGQGYTKTV 180
DWWTLGILLY EMMTGLPPYY DENVPVMYKK ILQQPLLFPD GFDPAAKDLL IGLLSRDPSR 240
RLGVNGTDEI RNHPFF 256
KeywordATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Drosophila melanogaster"; ?>Echinops telfairi"; ?>Vicugna pacos"; ?>Schizosaccharomyces pombe"; ?>
EKS-DRM-00075
EKS-ECT-00022
EKS-VIP-00075
EKS-SCP-00040
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0007047; P:cellular cell wall organization
GO:0070941; P:eisosome assembly
GO:0008360; P:regulation of cell shape
KEGG
sce:YMR104C;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013