EKS-SAC-00094

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00094

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	425.9	1.6E-128	76	336	261

Status

Reviewed

Ensembl Protein

YNL154C

UniProt Accession

P23292; D6W129;

Protein Name

Casein kinase I homolog 2

Protein Synonyms/Alias

Gene Name

YCK2

Gene Synonyms/Alias

YCK2; CKI1; YNL154C; N1755;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YNL154C	YNL154C	YNL154C

Organism

Saccharomyces cerevisiae

Functional Description

Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates.

Protein Length

546

Protein Sequence
(FASTA)

MSQVQSPLTA TNSGLAVNNN TMNSQMPNRS NVRLVNGTLP PSLHVSSNLN HNTGNSSASY 60

SGSQSRDDST IVGLHYKIGK KIGEGSFGVL FEGTNMINGL PVAIKFEPRK TEAPQLKDEY 120

RTYKILAGTP GIPQEYYFGQ EGLHNILVID LLGPSLEDLF DWCGRRFSVK TVVQVAVQMI 180

TLIEDLHAHD LIYRDIKPDN FLIGRPGQPD ANKVHLIDFG MAKQYRDPKT KQHIPYREKK 240

SLSGTARYMS INTHLGREQS RRDDMEAMGH VFFYFLRGQL PWQGLKAPNN KQKYEKIGEK 300

KRLTNVYDLA QGLPIQFGRY LEIVRNLSFE ETPDYEGYRM LLLSVLDDLG ETADGQYDWM 360

KLNGGRGWDL SINKKPNLHG YGHPNPPNEK SKRHRSKNHQ YSSPDHHHHY NQQQQQQQAQ 420

AQAQAQAQAK VQQQQLQQAQ AQQQANRYQL QPDDSHYDEE REASKLDPTS YEAYQQQTQQ 480

KYAQQQQKQM QQKSKQFANT GANGQTNKYP YNAQPTANDE QNAKNAAQDR NSNKSSKGFF 540

SKLGCC 546

Nucleotide Sequence
(FASTA)

ATGTCTCAAG TGCAAAGTCC TTTGACAGCA ACGAACTCTG GTTTAGCTGT CAATAATAAC 60

ACAATGAACT CACAAATGCC TAACCGTAGC AATGTTAGAT TGGTCAATGG TACTTTACCC 120

CCATCCTTAC ATGTTAGCTC TAACCTAAAT CACAACACTG GCAATAGCTC TGCCTCCTAT 180

TCTGGCTCAC AATCACGCGA CGATTCCACT ATAGTCGGGC TGCACTATAA GATAGGTAAG 240

AAAATCGGTG AAGGTTCATT TGGTGTACTT TTTGAAGGTA CAAACATGAT CAATGGATTA 300

CCAGTTGCTA TCAAGTTTGA ACCAAGAAAA ACAGAAGCCC CACAGCTAAA GGACGAATAT 360

CGGACCTATA AAATTTTAGC GGGAACACCT GGTATACCAC AAGAATACTA CTTTGGTCAG 420

GAAGGATTAC ATAACATATT GGTTATTGAT CTGCTTGGTC CTTCTTTAGA AGATTTATTC 480

GATTGGTGTG GAAGAAGATT TTCGGTAAAA ACTGTTGTAC AAGTCGCAGT ACAAATGATA 540

ACTTTAATTG AAGATTTGCA CGCTCATGAT TTGATATACC GTGATATTAA ACCTGATAAT 600

TTTTTGATCG GAAGACCGGG TCAACCAGAT GCTAACAAAG TTCATCTAAT TGACTTTGGT 660

ATGGCCAAAC AATATCGTGA TCCAAAAACT AAACAACATA TTCCGTACAG GGAAAAGAAA 720

TCATTAAGTG GCACAGCAAG ATACATGTCG ATAAATACAC ATTTGGGTAG AGAACAATCG 780

AGAAGAGACG ATATGGAAGC TATGGGTCAT GTCTTCTTTT ATTTCTTGAG GGGGCAGCTA 840

CCATGGCAAG GTTTGAAAGC ACCAAATAAC AAGCAAAAGT ACGAAAAAAT TGGCGAAAAG 900

AAAAGACTAA CAAATGTTTA CGATTTAGCT CAGGGTCTCC CAATCCAATT TGGTAGGTAT 960

TTGGAAATAG TCAGAAATTT ATCGTTTGAG GAAACTCCTG ATTATGAGGG CTACCGCATG 1020

TTACTTTTAT CTGTGTTGGA TGATTTAGGT GAAACAGCAG ATGGACAATA TGATTGGATG 1080

AAGCTGAATG GTGGCCGTGG TTGGGATTTG TCGATAAACA AAAAGCCGAA CTTACATGGT 1140

TATGGTCACC CAAATCCACC AAATGAAAAA TCAAAAAGGC ATAGAAGTAA AAACCATCAA 1200

TATTCATCAC CCGATCATCA CCATCATTAC AATCAACAGC AACAACAACA GCAGGCTCAG 1260

GCTCAAGCAC AGGCTCAAGC ACAAGCCAAA GTGCAGCAAC AACAATTGCA ACAAGCCCAG 1320

GCCCAGCAAC AGGCCAATCG TTATCAATTA CAACCAGATG ACTCGCACTA TGACGAAGAA 1380

AGAGAGGCGT CGAAGCTTGA TCCAACTTCG TATGAAGCAT ATCAGCAACA AACTCAACAA 1440

AAATATGCTC AGCAACAACA AAAGCAAATG CAACAGAAAT CCAAACAGTT TGCCAATACA 1500

GGTGCCAATG GTCAAACTAA CAAGTATCCA TATAATGCGC AACCAACGGC GAACGACGAA 1560

CAAAACGCTA AAAACGCAGC GCAAGATAGA AATAGTAACA AATCATCGAA AGGTTTTTTC 1620

AGTAAGCTAG GATGCTGTTA G 1641

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         y+++kkiG+GsfG +++g+n+++g  vaik+e++k++apqlk+e+r+ykil+g+ giP+

Q: 76    YKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQE  135

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +yfg+e+ +n+lv+dllGpsledlfd+c r+fs+ktv+ +a q+i+ ie +h+++liyrd

Q: 136   YYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRD  195

         ************************************************************

S: 121   ikPdnfllg..igrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthl  178

         ikPdnfl+g   +  ++kv+lidfG+ak+yrd+ktk+hipyre+ksl+Gtary+sinthl

Q: 196   IKPDNFLIGrpGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHL  255

         *******77433445678******************************************

S: 179   gkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPe  238

         g+eqsrrdd+e++g+v++yflrg+lPWqglka ++kqkyeki+ekk+ t++ +l++g+P

Q: 256   GREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPI  315

         ************************************************************

S: 239   efatylkyvrklkfeekPdye  259

         +f +yl++vr+l+fee+Pdye

Q: 316   QFGRYLEIVRNLSFEETPDYE  336

         ********************7

Domain Sequence
(FASTA)

YKIGKKIGEG SFGVLFEGTN MINGLPVAIK FEPRKTEAPQ LKDEYRTYKI LAGTPGIPQE 60

YYFGQEGLHN ILVIDLLGPS LEDLFDWCGR RFSVKTVVQV AVQMITLIED LHAHDLIYRD 120

IKPDNFLIGR PGQPDANKVH LIDFGMAKQY RDPKTKQHIP YREKKSLSGT ARYMSINTHL 180

GREQSRRDDM EAMGHVFFYF LRGQLPWQGL KAPNNKQKYE KIGEKKRLTN VYDLAQGLPI 240

QFGRYLEIVR NLSFEETPDY E 261

Keyword

ATP-binding; Cell membrane; Complete proteome; Kinase; Lipoprotein; Membrane; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005935	; C:cellular bud neck
GO:0005937	; C:mating projection
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000902	; P:cell morphogenesis
GO:0000910	; P:cytokinesis
GO:0006897	; P:endocytosis
GO:0009749	; P:response to glucose stimulus

KEGG

sce:YNL154C

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013