EKS-SAC-00062
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00062
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK323.44.0E-97496777282
StatusReviewed
Ensembl ProteinYNR047W
UniProt AccessionP53739; D6W1M2;
Protein NameFlippase kinase 1
Protein Synonyms/Alias
Gene NameFPK1
Gene Synonyms/Alias FPK1; YNR047W; N3449;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YNR047WYNR047WYNR047W
OrganismSaccharomyces cerevisiae
Functional DescriptionFlippase activator that phosphorylates DFN1 and DFN2 andwhich is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids and in the retrieval pathway from early endosomes to the trans-Golgi network (TGN). Phosphorylates also the N-terminal half of YPK1. Involved in pheromone-response.
Protein Length893
Protein Sequence
(FASTA)
MAGHHHEHEQ ERDHEQEHEH DSLQRPTTGS ERTRSISFSK LLTRSWKRNA SSSNNMSVSS 60
VNLYSDPENS RESDHNNSGS EGQSSRFSKL KSMFQSGNSS KNASAHNSSQ SSLEGDSASS 120
SSKLRYVKPM TSVANASPAS PPLSPTIPET DVLQTPKMVH IDQHEHEREH SNCGSPIMLS 180
SSSFSPTVAR TGTGRRRSPS TPIMPSQNSN NSSSTSAIRP NNYRHHSGSQ GFSSNNPFRE 240
RAGTVRSSNP YFAYQGLPTH AMSSHDLDEG FQPYANGSGI HFLSTPTSKT NSLTNTKNLS 300
NLSLNEIKEN EEVQEFNNED FFFHDIPKDL SLKDTLNGSP SRGSSKSPTI TQTFPSIIVG 360
FDNEYEEDNN NDKHDEKEEQ QTTTDNKTRN LSPTKQNGKA THPRIKIPLR RAASEPNGLQ 420
LASATSPTSS SARKTSGSSN INDKIPGQSV PPPNSFFPQE PSPKISDFPE PRRSRRLRTK 480
SFSNKFQDIM VGPQSFEKIR LLGQGDVGKV FLVREKKTNR VYALKVLSKD EMIKRNKIKR 540
VLTEQEILAT SNHPFIVTLY HSFQSEDYLY LCMEYCMGGE FFRALQTRKT KCICEDDARF 600
YASEVTAALE YLHLLGFIYR DLKPENILLH QSGHIMLSDF DLSIQAKDSK VPVVKGSAQS 660
TLVDTKICSD GFRTNSFVGT EEYIAPEVIR GNGHTAAVDW WTLGILIYEM LFGFTPFKGD 720
NTNETFTNIL KNEVSFPNNN EISRTCKDLI KKLLTKNESK RLGCKMGAAD VKKHPFFKKV 780
QWSLLRNQEP PLIPVLSEDG YDFAKLSSNK KRQTSQDSHK HLDEQEKNMF EERVEYDDEV 840
SEDDPFHDFN SMSLMEQDNN SMIYGNTNSY GKIAYTPNSN RSRSNSHRTF FKR 893
Nucleotide Sequence
(FASTA)
ATGGCTGGAC ACCATCACGA ACATGAACAA GAGCGCGACC ACGAGCAAGA ACACGAACAC 60
GATTCCCTTC AACGGCCTAC TACTGGATCA GAAAGGACTA GAAGTATATC CTTTTCGAAG 120
TTGCTTACGC GGTCATGGAA AAGGAATGCG AGTTCATCGA ACAACATGAG TGTGTCTAGC 180
GTGAATCTGT ATTCGGATCC AGAGAACTCG AGAGAATCAG ATCACAATAA TAGTGGCTCA 240
GAGGGCCAGT CTTCACGATT TTCTAAATTG AAAAGTATGT TCCAATCCGG CAATAGCAGC 300
AAAAATGCCA GTGCCCATAA CAGCAGCCAA AGCAGTCTTG AAGGTGACTC GGCGTCATCT 360
TCATCTAAGT TAAGATACGT TAAACCAATG ACTTCTGTTG CCAATGCTTC TCCGGCATCT 420
CCACCACTTT CTCCCACGAT CCCGGAAACG GATGTTCTTC AAACACCAAA GATGGTACAT 480
ATAGATCAAC ATGAACATGA GCGTGAACAC TCGAATTGCG GGTCTCCAAT AATGCTTTCA 540
TCATCCTCTT TCAGTCCTAC TGTTGCCAGG ACTGGGACGG GTAGGAGAAG ATCACCGTCT 600
ACTCCGATAA TGCCCAGTCA GAACTCGAAT AACTCTAGTA GCACCTCTGC TATCAGACCA 660
AATAATTATC GTCACCATTC AGGATCTCAG GGGTTTTCTT CCAACAATCC ATTCAGAGAA 720
AGGGCAGGTA CGGTACGCAG TAGTAACCCA TATTTTGCAT ACCAAGGTCT ACCAACTCAT 780
GCCATGTCTT CTCACGACCT CGATGAAGGA TTCCAACCAT ATGCAAATGG CAGCGGCATT 840
CACTTTTTGT CCACCCCCAC CTCGAAGACA AATTCTTTGA CAAACACCAA AAATTTAAGT 900
AATTTATCAC TAAACGAGAT TAAGGAAAAT GAAGAAGTGC AAGAATTCAA TAACGAGGAT 960
TTCTTCTTTC ACGATATTCC GAAAGATTTA TCGCTCAAAG ATACGCTGAA TGGCTCACCC 1020
AGTAGAGGTA GTTCCAAGAG CCCCACGATT ACTCAAACGT TCCCTTCAAT CATTGTCGGA 1080
TTTGACAATG AGTACGAGGA AGATAACAAC AATGATAAAC ATGATGAAAA GGAAGAACAA 1140
CAAACGACAA CCGACAATAA AACGAGAAAT CTTTCACCTA CCAAACAAAA TGGTAAAGCT 1200
ACCCATCCAA GGATAAAAAT ACCTTTAAGA AGAGCAGCTT CAGAACCAAA CGGGTTGCAA 1260
CTCGCATCTG CCACATCGCC GACATCTTCT TCAGCAAGGA AAACATCAGG GTCCAGTAAT 1320
ATAAACGACA AAATCCCAGG CCAATCAGTG CCTCCTCCAA ACTCATTTTT CCCTCAAGAA 1380
CCCTCTCCAA AGATTTCTGA TTTTCCAGAA CCTAGGAGGT CCCGACGTTT GAGAACTAAA 1440
TCTTTCAGCA ATAAATTTCA AGATATCATG GTGGGACCAC AGTCTTTTGA GAAAATAAGA 1500
TTGCTGGGCC AAGGTGATGT AGGTAAAGTT TTCTTAGTAA GAGAGAAAAA GACGAATAGA 1560
GTGTATGCTT TGAAAGTCTT GAGTAAAGAC GAAATGATAA AAAGAAATAA AATCAAACGT 1620
GTTCTGACAG AACAAGAGAT TCTTGCCACC AGCAATCATC CCTTCATCGT CACACTATAC 1680
CATTCGTTCC AATCTGAAGA CTATTTGTAT CTCTGTATGG AATACTGTAT GGGCGGGGAG 1740
TTTTTCAGAG CTTTACAAAC AAGGAAAACC AAATGTATAT GTGAAGACGA TGCCAGGTTT 1800
TATGCCAGTG AAGTGACAGC AGCACTAGAA TATTTACATC TGTTGGGTTT TATCTATAGA 1860
GATTTAAAAC CAGAGAATAT TTTGCTGCAT CAATCAGGCC ATATCATGCT TTCTGACTTC 1920
GACTTGTCTA TTCAGGCTAA AGATTCCAAG GTTCCTGTTG TCAAGGGTTC CGCTCAATCA 1980
ACCCTTGTTG ATACCAAAAT ATGCTCAGAT GGGTTTAGAA CCAATTCCTT TGTCGGAACT 2040
GAAGAATATA TTGCCCCTGA AGTCATAAGA GGTAATGGCC ACACCGCTGC GGTCGATTGG 2100
TGGACGCTAG GGATTTTGAT CTATGAAATG TTATTTGGTT TCACTCCATT CAAAGGCGAT 2160
AACACAAATG AAACTTTTAC GAATATTTTG AAAAATGAGG TCAGTTTTCC CAATAACAAT 2220
GAAATCTCCA GAACTTGTAA GGATTTGATC AAAAAATTAC TGACAAAAAA TGAATCTAAA 2280
AGACTGGGTT GCAAAATGGG CGCTGCCGAC GTGAAGAAAC ACCCCTTTTT CAAGAAAGTC 2340
CAATGGTCTT TGCTGAGAAA TCAAGAACCG CCTCTGATAC CAGTGTTATC TGAGGATGGA 2400
TATGATTTTG CTAAATTATC ATCTAATAAG AAGAGACAGA CTAGTCAAGA CAGCCATAAA 2460
CATCTCGATG AGCAAGAGAA AAATATGTTT GAAGAACGAG TTGAATACGA CGATGAAGTC 2520
TCTGAAGATG ATCCATTCCA TGACTTCAAT TCAATGAGTT TGATGGAACA GGATAACAAT 2580
TCAATGATTT ATGGTAATAC CAATTCTTAT GGGAAAATTG CATACACTCC AAACTCCAAC 2640
AGATCGAGGA GTAATAGTCA TCGAACCTTT TTTAAGAGAT AA 2682
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk.kkkertkeereiLeeve  59
         fe+++ lg+G++gkvflvr+   k+t+++ya+Kvl+k+e++k +k +r  +e+eiL++ +
Q: 496   FEKIRLLGQGDVGKVFLVRE---KKTNRVYALKVLSKDEMIKrNKIKRVLTEQEILATSN  552
         8999***************9...79**************9995667999***********
S: 60    hpfivklheafqdekklylvlellkGgeLlerlk..kkklfseeeasfilaelvlaleyl  117
         hpfiv+l+++fq+e++lyl++e+++Gge++++l+  k+k+++e++a+f+++e+++aleyl
Q: 553   HPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQtrKTKCICEDDARFYASEVTAALEYL  612
         *********************************977899*********************
S: 118   HskgvvyrDLkpeNilldeeghvkltDfgla....................kekiaenee  157
         H  g++yrDLkpeNill+++gh++l+Df+l+                    ++ki+++++
Q: 613   HLLGFIYRDLKPENILLHQSGHIMLSDFDLSiqakdskvpvvkgsaqstlvDTKICSDGF  672
         ************************************************************
S: 158   kaysfcgTleyvaPevlkrkgydeavDlwslGvllyemLtGktPftgeerketlarilkg  217
         +++sf+gT ey+aPev++ +g+++avD+w+lG+l+yemL+G tPf+g++++et+++ilk+
Q: 673   RTNSFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKN  732
         ************************************************************
S: 218   kfslklpaweelseeakdlvkklLkkdpakRlga..taeeikehkfl  262
         +  +++p+++e+s+++kdl+kklL+k+++kRlg+  +a+++k+h+f+
Q: 733   E--VSFPNNNEISRTCKDLIKKLLTKNESKRLGCkmGAADVKKHPFF  777
         *..99999999***********************9999*******97
Domain Sequence
(FASTA)
FEKIRLLGQG DVGKVFLVRE KKTNRVYALK VLSKDEMIKR NKIKRVLTEQ EILATSNHPF 60
IVTLYHSFQS EDYLYLCMEY CMGGEFFRAL QTRKTKCICE DDARFYASEV TAALEYLHLL 120
GFIYRDLKPE NILLHQSGHI MLSDFDLSIQ AKDSKVPVVK GSAQSTLVDT KICSDGFRTN 180
SFVGTEEYIA PEVIRGNGHT AAVDWWTLGI LIYEMLFGFT PFKGDNTNET FTNILKNEVS 240
FPNNNEISRT CKDLIKKLLT KNESKRLGCK MGAADVKKHP FF 282
KeywordATP-binding; Cell membrane; Complete proteome; Cytoplasm; Kinase; Lipid transport; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transport.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Gorilla gorilla"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Oryctolagus cuniculus"; ?>Schizosaccharomyces pombe"; ?>
EKS-ANC-00428
EKS-GOG-00433
EKS-MAM-00441
EKS-MEG-00366
EKS-ORC-00414
EKS-SCP-00068
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006869; P:lipid transport
GO:0061092; P:positive regulation of phospholipid translocation
GO:0046777; P:protein autophosphorylation
GO:0019236; P:response to pheromone
KEGG
sce:YNR047W;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013