EKS-SAC-00027
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00027
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PDK1428.73.2E-129179443265
StatusReviewed
Ensembl ProteinYOL100W
UniProt AccessionQ12236; D6W1W8;
Protein NameSerine/threonine-protein kinase PKH2
Protein Synonyms/Alias PKB-activating kinase homolog 2;
Gene NamePKH2
Gene Synonyms/Alias PKH2; YOL100W; HRC1081;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YOL100WYOL100WYOL100W
OrganismSaccharomyces cerevisiae
Functional DescriptionSerine/threonine-protein kinase which is partsphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P- body assembly and regulates global mRNA decay at the deadenylation step.
Protein Length1081
Protein Sequence
(FASTA)
MYFDKDNSMS PRPLLPSDEQ KLNINLLTKK EKFSHLDPHY DAKATPQRST SNRNVGDLLL 60
EKRTAKPMIQ KALTNTDNFI EMYHNQQRKN LDDDTIKEVM INDENGKTVA STNDGRYDND 120
YDNNDINDQK TLDNIAGSPH MEKNRNKVKI EHDSSSQKPI AKESSKAQKN IIKKGIKDFK 180
FGSVIGDGAY STVMLATSID TKKRYAAKVL NKEYLIRQKK VKYVSIEKTA LQKLNNSPSV 240
VRLFSTFQDE SSLYFLLEYA PNGDFLSLMK KYGSLDETCA RYYAAQIIDA IDYLHSNGII 300
HRDIKPENIL LDGEMKIKLT DFGTAKLLNP TNNSVSKPEY DLSTRSKSFV GTAEYVSPEL 360
LNDSFTDYRC DIWAFGCILF QMIAGKPPFK ATNEYLTFQK VMKVQYAFTP GFPLIIRDLV 420
KKILVKNLDR RLTISQIKEH HFFKDLNFKD GSVWSKTPPE IKPYKINAKS MQAMPSGSDR 480
KLVKKSVNTL GKSHLVTQRS ASSPSVEETT HSTLYNNNTH ASTESEISIK KRPTDERTAQ 540
ILENARKGIN NRKNQPGKRT PSGAASAALA ASAALTKKTM QSYPTSSSKS SRSSSPATTS 600
RPGTYKRTSS TESKPFAKSP PLSASVLSSK VPMPPYTPPM SPPMTPYDTY QMTPPYTTKQ 660
QDYSDTAIAA PKPCISKQNV KNSTDSPLMN KQDIQWSFYL KNINEHVLRT EKLDFVTTNY 720
DILEKKMLKL NGSLLDPQLF GKPRHTFLSQ VARSGGEVTG FRNDPTMTAY SKTEDTYYSK 780
NIIDLQLLED DYRIEGGDLS ELLTNRSGEG YKCNQNSSPM KDDDKSESNN KGSSVFSGKI 840
KKLFHPTSAA ETLSSSDEKT KYYKRTIVMT SFGRFLVFAK RRQPNPVTNL KYELEYDINL 900
RQQGTKIKEL IIPLEMGTNH IVVIQTPYKS FLLSTDKKTT SKLFTVLKKI LNSNTNKIEK 960
ELLQRNQKVI ERRTSSSGRA IPKDLPTSKS PSPKPRTHSQ SPSISKHNSF SESINSAKSN 1020
RSSRIFETFI NAKEQNSKKH AAPVPLTSKL VNGLPKRQVT VGLGLNTGTN FKNSSAKSKR 1080
S 1081
Nucleotide Sequence
(FASTA)
ATGTATTTTG ATAAGGATAA TTCCATGAGC CCTAGGCCGT TATTGCCAAG TGATGAGCAG 60
AAGCTAAACA TTAATCTTCT AACGAAAAAG GAGAAATTCT CGCATTTAGA CCCCCATTAT 120
GACGCAAAAG CCACTCCACA AAGAAGCACT TCGAATAGAA ACGTTGGCGA TTTACTTTTG 180
GAAAAAAGAA CCGCTAAGCC TATGATTCAA AAGGCCTTGA CGAATACGGA TAATTTCATT 240
GAAATGTACC ATAATCAGCA GAGAAAAAAT CTTGATGATG ACACTATTAA AGAAGTAATG 300
ATTAATGATG AAAACGGAAA AACTGTCGCT AGTACCAACG ACGGCAGATA TGACAACGAT 360
TACGATAATA ACGATATTAA TGACCAAAAA ACTTTGGATA ATATAGCGGG AAGTCCCCAC 420
ATGGAAAAAA ATCGAAACAA AGTAAAGATT GAACATGACT CTTCATCTCA AAAACCAATA 480
GCTAAAGAGT CATCCAAAGC CCAAAAAAAT ATAATCAAAA AGGGAATCAA GGACTTTAAA 540
TTTGGTAGTG TAATAGGTGA TGGCGCGTAT TCTACTGTAA TGTTAGCGAC GTCGATTGAT 600
ACCAAAAAGA GGTACGCCGC AAAAGTACTA AACAAAGAAT ATTTAATACG CCAGAAGAAA 660
GTCAAATACG TCAGCATAGA AAAAACCGCC CTTCAAAAGC TCAATAATTC TCCTAGTGTT 720
GTGCGATTAT TTTCCACTTT TCAGGATGAA TCAAGCCTAT ACTTTCTCTT AGAGTATGCC 780
CCCAATGGGG ACTTTCTTTC TTTAATGAAA AAATACGGTT CATTAGACGA AACCTGCGCA 840
CGATATTATG CTGCGCAAAT AATAGATGCC ATAGACTACT TACATTCCAA CGGTATTATT 900
CATAGAGATA TAAAACCAGA AAATATTCTT TTAGATGGAG AAATGAAGAT CAAACTGACT 960
GATTTTGGTA CTGCGAAGTT ACTGAATCCT ACAAATAATA GCGTTTCGAA ACCAGAATAC 1020
GATTTATCAA CAAGGTCGAA ATCTTTCGTT GGAACTGCAG AATACGTATC TCCAGAACTT 1080
TTAAATGACA GTTTTACAGA CTATCGTTGC GATATTTGGG CCTTCGGATG TATACTTTTC 1140
CAGATGATTG CCGGAAAACC ACCATTCAAA GCTACCAATG AATACTTGAC TTTCCAAAAG 1200
GTAATGAAAG TTCAGTACGC CTTTACACCA GGTTTCCCAC TTATTATCAG AGATTTGGTT 1260
AAGAAAATCT TAGTAAAAAA CTTAGACCGA AGATTGACGA TAAGCCAAAT TAAGGAACAT 1320
CATTTTTTCA AAGATTTGAA TTTTAAAGAC GGCTCTGTTT GGTCAAAAAC GCCTCCAGAG 1380
ATCAAACCAT ATAAAATCAA CGCCAAATCC ATGCAGGCAA TGCCAAGCGG AAGCGATAGA 1440
AAACTGGTGA AGAAATCAGT CAACACACTT GGCAAATCGC ATCTAGTGAC TCAAAGGTCA 1500
GCTTCAAGTC CCTCTGTTGA GGAAACTACT CATTCAACCC TATACAATAA CAATACTCAC 1560
GCTTCTACTG AAAGTGAAAT ATCAATAAAG AAGAGACCCA CTGATGAAAG AACAGCGCAG 1620
ATACTTGAAA ATGCAAGAAA GGGTATAAAC AATAGGAAAA ATCAACCAGG CAAGAGAACA 1680
CCAAGTGGTG CAGCTTCTGC TGCCCTAGCA GCTTCTGCTG CTTTAACCAA GAAAACCATG 1740
CAAAGCTATC CAACTTCTAG TTCGAAAAGT AGCAGGTCAA GCTCTCCTGC GACAACATCA 1800
AGACCAGGAA CTTATAAGCG TACTTCTTCT ACAGAAAGTA AACCATTTGC CAAATCTCCA 1860
CCTTTGTCAG CATCAGTTTT ATCGTCAAAA GTCCCAATGC CTCCATACAC ACCTCCAATG 1920
TCGCCCCCTA TGACACCATA TGATACATAT CAAATGACAC CTCCCTATAC GACAAAACAG 1980
CAGGATTATT CTGATACCGC AATTGCCGCA CCTAAGCCTT GTATTAGTAA GCAAAATGTT 2040
AAAAATAGCA CAGATTCTCC CTTGATGAAC AAGCAAGATA TTCAATGGTC CTTTTACCTG 2100
AAAAACATCA ACGAACATGT ACTAAGGACG GAAAAACTGG ATTTTGTTAC CACAAATTAC 2160
GATATCTTAG AGAAGAAAAT GCTTAAACTA AATGGTTCAT TGTTAGATCC TCAACTGTTT 2220
GGTAAGCCTA GACATACTTT TTTATCCCAA GTAGCTAGGA GTGGGGGAGA GGTTACAGGT 2280
TTTCGAAATG ATCCAACTAT GACTGCTTAT TCCAAAACAG AAGATACGTA CTATTCGAAA 2340
AATATTATCG ATTTGCAGCT CTTGGAAGAT GATTATCGAA TTGAAGGAGG TGACTTATCG 2400
GAGTTGCTTA CTAACAGAAG CGGAGAAGGG TACAAATGCA ATCAAAACAG CTCACCAATG 2460
AAAGACGATG ATAAATCCGA ATCTAACAAT AAAGGAAGCT CTGTTTTTTC TGGCAAGATT 2520
AAAAAATTAT TTCACCCTAC CTCAGCAGCT GAAACGCTCT CTTCCTCTGA TGAAAAAACC 2580
AAGTACTATA AACGAACCAT TGTAATGACA TCATTTGGAA GGTTTCTAGT ATTTGCCAAG 2640
AGGAGGCAGC CAAATCCAGT TACAAATTTA AAGTATGAAC TAGAATATGA CATAAATTTG 2700
CGTCAACAGG GTACCAAAAT AAAAGAACTA ATCATTCCCT TGGAAATGGG AACTAATCAT 2760
ATAGTTGTGA TTCAGACACC TTACAAGTCA TTTCTTTTGA GCACTGATAA AAAAACCACG 2820
AGCAAATTGT TTACTGTTCT CAAAAAAATT CTTAATTCGA ATACAAATAA AATAGAGAAA 2880
GAACTGTTGC AAAGAAACCA AAAGGTAATT GAAAGAAGAA CATCATCATC CGGAAGAGCC 2940
ATACCTAAAG ATCTTCCAAC TTCCAAGTCT CCTTCGCCAA AACCCAGGAC GCATAGCCAA 3000
TCTCCATCAA TTTCAAAGCA CAATTCGTTT TCTGAATCGA TTAATAGCGC TAAGAGCAAC 3060
AGATCAAGCA GAATTTTTGA AACCTTTATC AATGCCAAGG AACAAAATTC AAAAAAACAC 3120
GCTGCTCCAG TACCGTTAAC CAGTAAATTA GTTAACGGAT TGCCAAAAAG ACAAGTTACC 3180
GTGGGATTAG GTCTAAACAC AGGAACAAAT TTCAAAAACT CATCTGCAAA ATCGAAGAGG 3240
TCGTAA 3246
Domain Profile
S: 1     fkfekelgeGsystvvlarekeskkeyaikvlekryiikekkvkyvtrekevlaklnehp  60
         fkf++ +g+G+ystv+la+++++kk+ya kvl+k+y+i++kkvkyv++ek++l+kln++p
Q: 179   FKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSP  238
         89**********************************************************
S: 61    givkLyatfqDeeslyfvleyakkGdllellkkvgsfdeactryyaaellsaleflhkkg  120
         ++v+L++tfqDe+slyf+leya++Gd+l+l+kk+gs+de+c+ryyaa++++a+++lh++g
Q: 239   SVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNG  298
         ************************************************************
S: 121   iihrDlkpeniLldkdgkilitDfGsakvlepklkedskkeeeesarsksfvGtaeyvsP  180
         iihrD+kpeniLld ++ki++tDfG+ak+l+p++++ sk+e++ s+rsksfvGtaeyvsP
Q: 299   IIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSP  358
         ************************************************************
S: 181   elLtdsevskssDlWalgcilyqllaGkpPfraeneylifkkilkleyafpegfpekakd  240
         elL+ds +++++D+Wa+gcil+q++aGkpPf+a+neyl+f+k++k++yaf++gfp  ++d
Q: 359   ELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRD  418
         ************************************************************
S: 241   lveklLvkdakerltleeikahkff  265
         lv+k+Lvk+ ++rlt+++ik+h+ff
Q: 419   LVKKILVKNLDRRLTISQIKEHHFF  443
         ************************9
Domain Sequence
(FASTA)
FKFGSVIGDG AYSTVMLATS IDTKKRYAAK VLNKEYLIRQ KKVKYVSIEK TALQKLNNSP 60
SVVRLFSTFQ DESSLYFLLE YAPNGDFLSL MKKYGSLDET CARYYAAQII DAIDYLHSNG 120
IIHRDIKPEN ILLDGEMKIK LTDFGTAKLL NPTNNSVSKP EYDLSTRSKS FVGTAEYVSP 180
ELLNDSFTDY RCDIWAFGCI LFQMIAGKPP FKATNEYLTF QKVMKVQYAF TPGFPLIIRD 240
LVKKILVKNL DRRLTISQIK EHHFF 265
KeywordATP-binding; Complete proteome; Cytoplasm; Endocytosis; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00220
EKS-ANC-00227
EKS-BOT-00259
EKS-CAE-00233
EKS-CAJ-00265
EKS-CAF-00244
EKS-CAP-00262
EKS-CII-00142
EKS-CIS-00018
EKS-DAR-00591
EKS-EQC-00229
EKS-FEC-00243
EKS-GAG-00217
EKS-GOG-00235
EKS-HOS-00244
EKS-LOA-00267
EKS-MOD-00257
EKS-MUM-00290
EKS-MUP-00236
EKS-MYL-00261
EKS-NOL-00238
EKS-OCP-00019
EKS-ORC-00212
EKS-ORL-00285
EKS-OTG-00243
EKS-PAT-00246
EKS-PES-00231
EKS-POA-00232
EKS-RAN-00274
EKS-SAH-00222
EKS-SOA-00014
EKS-TEN-00298
EKS-TUT-00028
EKS-XET-00312
EKS-XIM-00298
EKS-SCP-00012
Gene Ontology
GO:0032126; C:eisosome
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0033962; P:cytoplasmic mRNA processing body assembly
GO:0006897; P:endocytosis
GO:0000196; P:MAPK cascade involved in cell wall biogenesis
GO:0060211; P:regulation of nuclear-transcribed mRNA poly(A) tail shortening
KEGG
sce:YOL100W;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013