EPS-SAC-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAC-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	172.2	5.8E-51	187	448	262

Status

Reviewed

Ensembl Protein

YOR090C

UniProt Accession

Q12511; D6W2F1;

Protein Name

Protein phosphatase 2C homolog 5

Protein Synonyms/Alias

PP2C-5; Phosphatase two C protein 5; Protein phosphatase of PDH protein 5;

Gene Name

PTC5

Gene Synonyms/Alias

PTC5; PPP1; YOR090C; YOR3157C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YOR090C	YOR090C	YOR090C

Organism

Saccharomyces cerevisiae

Functional Description

Involved in regulation of pyruvate dehydrogenaseactivity.

Protein Length

572

Protein Sequence
(FASTA)

MSPLTRTVAI KKTVKVLSKC QSGREYTQKF LQRAYSTSHA NSTYYSRTKL FISSHSKALN 60

IALLSGSLLL TYSYYSPKKI LSLDTINGIK DYSTNTSGNI NMPSPNPKGT ETQKSQRSQN 120

DQSVLILNDS KIEAKLHDRE ESHFVNRGTG IFRYDVAQLP SNHPIEDDHV EQIITIPIES 180

EDGKSIEKDL YFFGIFDGHG GPFTSEKLSK DLVRYVAYQL GQVYDQNKTV FHSDPNQLID 240

SAISKGFLKL DNDLVIESFR KLFQDPNNTN IANTLPAISG SCALLSLYNS TNSILKVAVT 300

GDSRALICGL DNEGNWTVKS LSTDQTGDNL DEVRRIRKEH PGEPNVIRNG RILGSLQPSR 360

AFGDYRYKIK EVDGKPLSDL PEVAKLYFRR EPRDFKTPPY VTAEPVITSA KIGENTKFMV 420

MGSDGLFELL TNEEIASLVI RWMDKNMNLA PVKAEPGKLP KVIDVSEDKE AQRPAFRYKD 480

NNSSSPSGSN PEYLIEDKNV ATHLIRNALS AGGRKEYVSA LVSIPSPMSR RYRDDLTVTV 540

AFFGDSGTPS IVSNATSIVM NPEATTKPKP RL 572

Nucleotide Sequence
(FASTA)

ATGTCTCCCT TAACTAGAAC CGTAGCTATA AAGAAAACGG TTAAGGTTCT ATCTAAATGT 60

CAATCTGGTA GAGAATACAC ACAGAAGTTT CTCCAACGTG CATATTCAAC ATCACATGCC 120

AACAGCACAT ACTATTCAAG GACAAAGCTA TTCATATCAT CACATTCTAA AGCTCTAAAC 180

ATTGCTCTAC TAAGCGGGTC CCTACTGTTG ACCTACTCCT ACTATTCCCC TAAAAAGATC 240

CTCTCCCTTG ATACAATTAA CGGAATAAAA GATTATTCTA CAAATACTAG TGGTAACATT 300

AACATGCCGT CACCTAATCC AAAAGGAACA GAGACACAAA AGAGTCAACG GTCTCAGAAT 360

GACCAATCTG TTCTTATCTT GAACGATTCT AAAATAGAGG CTAAACTACA TGATAGAGAG 420

GAAAGCCATT TTGTTAACCG TGGCACTGGT ATATTCAGGT ATGATGTGGC ACAGTTGCCC 480

TCTAACCATC CAATAGAAGA CGATCACGTA GAACAAATCA TTACCATTCC GATAGAAAGT 540

GAGGATGGCA AGTCCATAGA GAAGGATTTG TATTTTTTTG GAATTTTTGA TGGACATGGT 600

GGTCCTTTCA CTTCGGAAAA ATTATCTAAA GATCTAGTCC GTTATGTAGC GTATCAATTA 660

GGTCAGGTAT ATGACCAGAA CAAAACGGTT TTCCATTCCG ACCCCAACCA ATTAATCGAT 720

TCTGCAATTT CGAAAGGTTT TTTGAAACTA GATAATGATC TTGTAATCGA ATCGTTCAGG 780

AAGCTGTTTC AAGATCCAAA CAACACAAAT ATTGCAAACA CTTTACCAGC GATTTCTGGT 840

TCTTGTGCAC TATTAAGTTT ATACAACTCC ACTAACTCAA TTTTGAAAGT GGCTGTCACT 900

GGAGACTCAA GGGCTTTAAT TTGTGGTTTG GACAACGAGG GCAATTGGAC GGTAAAGTCG 960

CTATCCACCG ACCAGACCGG TGATAATTTG GATGAAGTAC GGAGAATTAG GAAAGAACAT 1020

CCAGGAGAAC CAAACGTTAT AAGAAACGGA AGAATATTGG GTTCATTACA ACCATCCAGG 1080

GCATTTGGAG ACTATCGCTA CAAGATCAAA GAAGTCGATG GAAAACCATT ATCGGATTTG 1140

CCTGAAGTTG CCAAACTTTA TTTTAGAAGA GAGCCAAGGG ATTTCAAGAC ACCCCCATAT 1200

GTCACTGCGG AACCAGTGAT TACTTCTGCC AAAATTGGTG AGAACACTAA ATTTATGGTG 1260

ATGGGTTCGG ATGGTTTATT CGAATTACTA ACTAATGAAG AAATTGCTTC CTTGGTTATC 1320

AGGTGGATGG ATAAAAATAT GAATCTGGCA CCTGTGAAGG CAGAACCGGG GAAATTACCA 1380

AAAGTTATCG ATGTATCTGA AGACAAGGAA GCACAAAGAC CGGCATTCAG GTACAAGGAT 1440

AATAATTCGA GCTCACCATC AGGATCAAAC CCAGAGTATC TTATTGAAGA CAAAAACGTC 1500

GCCACTCATT TAATTAGAAA TGCATTAAGT GCGGGCGGAA GAAAAGAATA TGTATCGGCA 1560

TTGGTAAGTA TACCATCGCC GATGAGTAGA AGATACAGAG ATGACTTGAC AGTAACAGTG 1620

GCGTTCTTTG GTGATTCTGG AACACCCTCA ATTGTCTCCA ATGCTACTTC AATAGTTATG 1680

AACCCGGAGG CAACAACAAA GCCAAAACCT AGATTATGA 1719

Domain Profile

S: 31    kkdrlaffgvyDGhggsevakfcseklheilaeele.........sseseerkvkkalak  81

         +kd l+ffg++DGhgg  +++++s++l +++a +l          ++++ ++ +++a+ k

Q: 187   EKD-LYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGqvydqnktvFHSDPNQLIDSAISK  245

         233.89******************************************************

S: 82    aFlstdeel.......kvleeksldidk..........sGstavvalikds..klyvanv  122

         +Fl++d++l         +++++    +          sGs+a+++l++++   l va +

Q: 246   GFLKLDNDLviesfrkL-FQDPN----NtniantlpaiSGSCALLSLYNSTnsILKVAVT  300

         *********99888852.33332....22233477888***********99756778***

S: 123   GdSravLcr.ngk....avelssdHkpsredEleRieeag...gsvilkdgaRvlGvLav  174

         GdSra++c  +++    +++ls+d + ++ dE++Ri++++   ++vi++   R+lG+L++

Q: 301   GDSRALICGlDNEgnwtVKSLSTDQTGDNLDEVRRIRKEHpgePNVIRNG--RILGSLQP  358

         *********54458899***********************9999****99..********

S: 175   sRalGdlylk..............................pyvtpePevtshrltsedef  204

         sRa+Gd+++k                              pyvt+eP +ts ++ ++++f

Q: 359   SRAFGDYRYKikevdgkplsdlpevaklyfrreprdfktpPYVTAEPVITSAKIGENTKF  418

         ************************************************************

S: 205   liLasDGlwdvvsneeavslvrdvlekkea  234

         ++++sDGl+++++nee+ slv ++++k+ +

Q: 419   MVMGSDGLFELLTNEEIASLVIRWMDKNMN  448

         ************************994433

Domain Sequence
(FASTA)

EKDLYFFGIF DGHGGPFTSE KLSKDLVRYV AYQLGQVYDQ NKTVFHSDPN QLIDSAISKG 60

FLKLDNDLVI ESFRKLFQDP NNTNIANTLP AISGSCALLS LYNSTNSILK VAVTGDSRAL 120

ICGLDNEGNW TVKSLSTDQT GDNLDEVRRI RKEHPGEPNV IRNGRILGSL QPSRAFGDYR 180

YKIKEVDGKP LSDLPEVAKL YFRREPRDFK TPPYVTAEPV ITSAKIGENT KFMVMGSDGL 240

FELLTNEEIA SLVIRWMDKN MN 262

Keyword

Complete proteome; Hydrolase; Magnesium; Manganese; Membrane; Metal-binding; Mitochondrion; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0031966	; C:mitochondrial membrane
GO:0005739	; C:mitochondrion
GO:0004741	; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0043085	; P:positive regulation of catalytic activity
GO:0006470	; P:protein dephosphorylation

KEGG

sce:YOR090C

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013