EKS-SAC-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/RIO	325.6	5.1E-98	98	321	224

Status

Reviewed

Ensembl Protein

YOR119C

UniProt Accession

Q12196; D6W2H8; Q00602;

Protein Name

Serine/threonine-protein kinase RIO1

Protein Synonyms/Alias

Ribosomal RNA-processing protein 10;

Gene Name

RIO1

Gene Synonyms/Alias

RIO1; RRP10; YOR119C; O3266, YOR3266C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YOR119C	YOR119C	YOR119C

Organism

Saccharomyces cerevisiae

Functional Description

Required for the final endonucleolytic cleavage at siteD converting 20S pre-rRNA into the mature 18S rRNA. Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase. Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation.

Protein Length

484

Protein Sequence
(FASTA)

MSLEDKFDSL SVSQGASDHI NNQLLEKYSH KIKTDELSFS RAKTSKDKAN RATVENVLDP 60

RTMRFLKSMV TRGVIADLNG CLSTGKEANV YHAFAGTGKA PVIDEETGQY EVLETDGSRA 120

EYAIKIYKTS ILVFKDRERY VDGEFRFRNS RSQHNPRKMI KIWAEKEFRN LKRIYQSGVI 180

PAPKPIEVKN NVLVMEFLSR GNGFASPKLK DYPYKNRDEI FHYYHTMVAY MRLLYQVCRL 240

VHADLSEYNT IVHDDKLYMI DVSQSVEPEH PMSLDFLRMD IKNVNLYFEK MGISIFPERV 300

IFQFVISETL EKFKGDYNNI SALVAYIASN LPIKSTEQDE AEDEIFRSLH LVRSLGGLEE 360

RDFDRYTDGK FDLLKSLIAH DNERNFAASE QFEFDNADHE CSSGTEEFSD DEEDGSSGSE 420

EDDEEEGEYY DDDEPKVLKG KKHEDKDLKK LRKQEAKDAK REKRKTKVKK HIKKKLVKKT 480

KSKK 484

Nucleotide Sequence
(FASTA)

ATGTCCTTGG AAGATAAATT TGATTCATTG TCTGTGTCGC AAGGTGCCTC GGACCATATT 60

AATAATCAGC TCTTAGAGAA GTATAGTCAC AAAATAAAAA CTGATGAATT ATCATTCAGC 120

AGAGCGAAAA CATCAAAGGA TAAAGCAAAT AGGGCGACTG TGGAAAATGT CTTAGATCCG 180

AGAACTATGA GATTTTTGAA GTCTATGGTC ACCAGAGGTG TGATTGCAGA TTTGAACGGT 240

TGCTTAAGTA CTGGGAAAGA AGCTAATGTT TACCACGCTT TTGCAGGTAC CGGTAAGGCA 300

CCCGTAATAG ATGAGGAAAC AGGCCAGTAT GAAGTTTTAG AGACAGACGG ATCCCGTGCA 360

GAATATGCCA TTAAGATTTA TAAGACCTCT ATCCTAGTCT TCAAAGATCG TGAAAGATAT 420

GTTGATGGTG AATTTAGATT TAGAAATTCC AGATCTCAAC ATAATCCAAG GAAAATGATT 480

AAAATTTGGG CTGAAAAGGA ATTTAGGAAC CTGAAAAGAA TTTATCAAAG TGGCGTCATT 540

CCAGCTCCTA AGCCAATAGA AGTTAAGAAC AACGTCTTAG TTATGGAATT TTTAAGCCGA 600

GGTAATGGAT TTGCCTCACC TAAATTAAAA GATTATCCGT ACAAGAATCG TGATGAAATT 660

TTCCATTATT ATCACACAAT GGTGGCATAT ATGAGATTGC TGTACCAAGT TTGTCGCCTG 720

GTTCATGCCG ATTTGTCAGA GTATAACACC ATAGTTCATG ATGATAAACT ATATATGATC 780

GATGTTTCCC AAAGTGTGGA ACCTGAACAT CCAATGAGTT TAGATTTTTT AAGGATGGAT 840

ATCAAAAACG TTAACCTTTA TTTCGAGAAG ATGGGTATAA GTATTTTCCC TGAAAGGGTT 900

ATTTTTCAAT TTGTCATATC AGAAACTTTG GAGAAATTTA AAGGTGATTA TAACAATATT 960

AGCGCCTTGG TTGCATACAT TGCTAGTAAT CTACCAATAA AATCTACAGA ACAAGATGAG 1020

GCAGAAGATG AAATATTCAG ATCGCTGCAT TTAGTTAGAT CATTGGGTGG ATTAGAGGAA 1080

AGAGATTTTG ATAGGTATAC TGATGGTAAG TTTGACTTAC TGAAAAGCTT GATTGCCCAT 1140

GATAATGAAC GCAATTTTGC TGCTTCTGAG CAATTTGAAT TTGATAACGC TGACCACGAA 1200

TGTAGTTCTG GCACAGAGGA ATTCTCAGAT GATGAAGAAG ACGGCTCAAG CGGATCTGAA 1260

GAAGATGACG AGGAGGAGGG CGAGTACTAT GACGATGATG AACCAAAAGT TTTAAAGGGG 1320

AAGAAACATG AGGACAAGGA TTTAAAAAAA TTGCGCAAGC AGGAAGCTAA AGATGCAAAA 1380

AGAGAAAAAA GGAAAACAAA AGTCAAGAAG CACATCAAGA AAAAATTGGT GAAAAAAACG 1440

AAATCAAAGA AATAA 1455

Domain Profile

S: 4     gntigvgkesdvykvsekngee..raiKiyktsllvlknrdkYvdgefrfkksrskanpr  61

         g ++++++e+++y+v+e++g++  +aiKiykts+lv+k+r++Yvdgefrf++srs++npr

Q: 98    GKAPVIDEETGQYEVLETDGSRaeYAIKIYKTSILVFKDRERYVDGEFRFRNSRSQHNPR  157

         56789****************999************************************

S: 62    klsrlwAeKEfrnlkrlyekgv.pvPepidlkrhvlvmeligr.dgypapklkdvkl.ke  118

         k++++wAeKEfrnlkr+y++gv p+P+pi++k++vlvme+++r +g+++pklkd+++ ++

Q: 158   KMIKIWAEKEFRNLKRIYQSGViPAPKPIEVKNNVLVMEFLSRgNGFASPKLKDYPYkNR  217

         *********************99**********************************999

S: 119   eeikelYsdllalivklynegrLvHaDlsEfnilleddklvliDvsqsveieHpdalefl  178

         +ei+++Y++++a+++ ly+ +rLvHaDlsE+n++++ddkl++iDvsqsve+eHp++l+fl

Q: 218   DEIFHYYHTMVAYMRLLYQVCRLVHADLSEYNTIVHDDKLYMIDVSQSVEPEHPMSLDFL  277

         ************************************************************

S: 179   rrDvknvkefFkkklvydvlrerelfelvsasgltkekeaddeil  223

         r+D+knv+ +F+k+++ ++++er++f++v++++l+k+k ++++i

Q: 278   RMDIKNVNLYFEKMGI-SIFPERVIFQFVISETLEKFKGDYNNIS  321

         ****************.***********************98875

Domain Sequence
(FASTA)

GKAPVIDEET GQYEVLETDG SRAEYAIKIY KTSILVFKDR ERYVDGEFRF RNSRSQHNPR 60

KMIKIWAEKE FRNLKRIYQS GVIPAPKPIE VKNNVLVMEF LSRGNGFASP KLKDYPYKNR 120

DEIFHYYHTM VAYMRLLYQV CRLVHADLSE YNTIVHDDKL YMIDVSQSVE PEHPMSLDFL 180

RMDIKNVNLY FEKMGISIFP ERVIFQFVIS ETLEKFKGDY NNIS 224

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Kinase; Mitosis; Nucleotide-binding; Phosphoprotein; Reference proteome; Ribosome biogenesis; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051301	; P:cell division
GO:0000462	; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007067	; P:mitosis
GO:0007096	; P:regulation of exit from mitosis
GO:0000084	; P:S phase of mitotic cell cycle

KEGG

sce:YOR119C

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR018934	; RIO-like_kinase.
IPR000687	; RIO_kinase.
IPR018935	; RIO_kinase_CS.

Pfam

PF01163

; RIO1; 1.

SMARTs

SM00090

; RIO; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS01245	; RIO1; 1.

Prints

Created Date

20-Feb-2013