EKS-SAC-00014
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAC-00014
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE7311.02.2E-93215481267
StatusReviewed
Ensembl ProteinYPL140C
UniProt AccessionP32491; D6W3M8;
Protein NameMAP kinase kinase MKK2/SSP33
Protein Synonyms/Alias
Gene NameMKK2
Gene Synonyms/Alias MKK2; SSP33; YPL140C; LPI6C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
YPL140CYPL140CYPL140C
OrganismSaccharomyces cerevisiae
Functional DescriptionSerine/threonine protein kinase involved in a signaltransduction pathway that play a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
Protein Length506
Protein Sequence
(FASTA)
MASMFRPPES NRSHQKTPKL TLPVNLVQNA KSTNDGQHLN RSPYSSVNES PYSNNSTSAT 60
STTSSMASNS TLLYNRSSTT TIKNRPVPPP LPPLVLTQKK DGIEYRVAGD SQLSERFSNL 120
HVDITYKELL SSAPISTKLS NIDTTFIKKD LDTPEGEDSY PSTLLSAYDF SSSGSNSAPL 180
SANNIISCSN LIQGKDVDQL EEEAWRFGHL KDEITTLGIL GEGAGGSVAK CRLKNGKKVF 240
ALKTINTMNT DPEYQKQIFR ELQFNKSFKS DYIVQYYGMF TDEQSSSIYI AMEYMGGKSL 300
EATYKNLLKR GGRISERVIG KIAESVLRGL SYLHERKVIH RDIKPQNILL NEKGEIKLCD 360
FGVSGEAVNS LAMTFTGTSF YMAPERIQGQ PYSVTCDVWS LGLTLLEVAG GRFPFESDKI 420
TQNVAPIELL TMILTFSPQL KDEPELDISW SKTFRSFIDY CLKKDARERP SPRQMLKHPW 480
IVGQMKKKVN MERFVKKCWE KEKDGI 506
Nucleotide Sequence
(FASTA)
ATGGCTTCAA TGTTCAGACC ACCAGAATCC AATAGGAGTC ACCAAAAGAC TCCAAAATTA 60
ACGCTTCCAG TAAATTTAGT TCAAAATGCG AAATCCACTA ATGATGGGCA ACATCTCAAC 120
CGGTCACCGT ACTCGTCAGT GAACGAAAGC CCATACTCCA ACAATAGCAC TTCAGCTACT 180
TCCACTACGT CATCCATGGC TTCAAATTCC ACTTTGTTGT ACAATAGATC ATCTACTACA 240
ACTATTAAAA ATAGACCGGT ACCACCTCCA TTACCTCCCC TAGTACTAAC GCAAAAAAAA 300
GACGGTATAG AATATAGAGT TGCCGGCGAT AGTCAGCTTT CTGAAAGATT TTCTAATTTG 360
CATGTTGATA TAACTTACAA GGAACTACTA TCTAGTGCTC CAATTTCCAC TAAGTTATCC 420
AACATAGATA CCACTTTTAT CAAGAAAGAT CTCGACACAC CAGAAGGCGA GGATTCATAC 480
CCCTCGACAC TTCTTTCTGC GTACGACTTC AGCAGTAGCG GGAGCAACTC CGCCCCTTTA 540
AGTGCAAATA ACATAATTTC TTGTTCCAAC TTAATACAAG GAAAAGACGT AGACCAGTTA 600
GAGGAAGAAG CATGGAGGTT TGGGCATCTC AAGGATGAGA TTACTACACT AGGAATTCTA 660
GGAGAAGGCG CGGGTGGTTC TGTAGCCAAG TGCCGATTAA AAAATGGAAA AAAGGTTTTT 720
GCGTTGAAGA CAATCAACAC TATGAATACT GACCCAGAAT ATCAAAAGCA AATATTCAGA 780
GAGCTACAAT TTAATAAGAG TTTTAAGTCC GATTATATTG TGCAGTACTA TGGTATGTTT 840
ACCGACGAAC AGAGTTCTTC AATATACATT GCCATGGAAT ATATGGGAGG AAAATCACTG 900
GAGGCAACGT ATAAAAATTT GTTGAAACGT GGCGGTAGAA TAAGTGAGAG GGTGATAGGA 960
AAGATAGCAG AATCTGTCTT AAGAGGTTTA TCATACTTAC ACGAAAGGAA AGTCATCCAC 1020
AGGGACATTA AACCCCAAAA CATTCTTCTT AATGAAAAAG GGGAAATCAA ATTATGCGAT 1080
TTCGGTGTCA GTGGGGAGGC TGTTAACTCT TTAGCGATGA CATTTACTGG AACGTCATTT 1140
TATATGGCCC CAGAACGAAT ACAAGGCCAA CCATACAGCG TAACCTGTGA TGTATGGTCC 1200
TTAGGATTAA CTCTTCTGGA GGTTGCTGGA GGGAGATTTC CATTTGAATC TGACAAAATA 1260
ACGCAAAACG TGGCTCCTAT AGAATTATTG ACGATGATCC TGACGTTTTC TCCCCAGTTG 1320
AAAGATGAGC CAGAACTAGA CATATCCTGG AGCAAGACAT TTAGATCTTT TATCGACTAT 1380
TGTTTAAAAA AAGATGCCAG AGAGAGGCCT TCTCCCAGGC AAATGTTAAA GCATCCCTGG 1440
ATTGTAGGGC AAATGAAAAA AAAAGTCAAC ATGGAACGGT TTGTAAAGAA ATGCTGGGAA 1500
AAGGAAAAGG ATGGGATATA A 1521
Domain Profile
S: 2     ekleelGaGnggvVekvlhkksgkilavKtir.leikkeeqkqilrelevlkkssnspyi  60
         ++l+ lG+G+gg+V k++ k+ +k++a Kti+ +++++e qkqi+rel+ ++ks +s+yi
Q: 215   TTLGILGEGAGGSVAKCRLKNGKKVFALKTINtMNTDPEYQKQIFRELQ-FNKSFKSDYI  273
         57889***************************99***************.88899*****
S: 61    vkfyGafvse..gdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleyl  118
         v++yG+f++e  ++++i+me+m g+sl++ +k++l++ +ri+e+v+gkia +v+++l+yl
Q: 274   VQYYGMFTDEqsSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYL  333
         ********9977889*********************************************
S: 119   keklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkk  178
         +e+ k+iHRD+KP+NiL+n+kGe+KlCDFGvsg+ v+s+A +++Gt+ YmaPEri+g + 
Q: 334   HER-KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQG-QP  391
         *88.9****************************************************.**
S: 179   YsvksdvWslGltlvelatgrypyeklke.....ilellkaivneeppklpee....efs  229
         Ysv++dvWslGltl+e+a gr+p+e+ k      ++ell++i++ +p+ ++e     ++s
Q: 392   YSVTCDVWSLGLTLLEVAGGRFPFESDKItqnvaPIELLTMILTFSPQLKDEPeldiSWS  451
         ************************99887888999**********9999988788999**
S: 230   eefqefvskClkkdekeRpklkellkhafi  259
         ++f++f++ Clkkd +eRp+ +++lkh++i
Q: 452   KTFRSFIDYCLKKDARERPSPRQMLKHPWI  481
         ****************************97
Domain Sequence
(FASTA)
TTLGILGEGA GGSVAKCRLK NGKKVFALKT INTMNTDPEY QKQIFRELQF NKSFKSDYIV 60
QYYGMFTDEQ SSSIYIAMEY MGGKSLEATY KNLLKRGGRI SERVIGKIAE SVLRGLSYLH 120
ERKVIHRDIK PQNILLNEKG EIKLCDFGVS GEAVNSLAMT FTGTSFYMAP ERIQGQPYSV 180
TCDVWSLGLT LLEVAGGRFP FESDKITQNV APIELLTMIL TFSPQLKDEP ELDISWSKTF 240
RSFIDYCLKK DARERPSPRQ MLKHPWI 267
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004708; F:MAP kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0030242; P:peroxisome degradation
KEGG
sce:YPL140C;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013