EKS-SAC-00112

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00112

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	357.8	1.2E-107	30	359	330

Status

Reviewed

Ensembl Protein

YPL236C

UniProt Accession

Q12003; D6W3D4; Q7LGU7;

Protein Name

Serine/threonine-protein kinase ENV7

Protein Synonyms/Alias

Late endosome and vacuole interface protein 7;

Gene Name

ENV7

Gene Synonyms/Alias

ENV7; YPL236C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YPL236C	YPL236C	YPL236C

Organism

Saccharomyces cerevisiae

Functional Description

Serine/threonine-protein kinase involved in vacuolarprocessing and morphology.

Protein Length

364

Protein Sequence
(FASTA)

MISIVLELFQ NLCCCRGFSD ATIRVNDKRY RIQRLLGEGG MSFVYLVQLS KNSLIIDNGI 60

ATPELYALKK IICPSVESIS NGMREIENYK RFQSPYVIKS IDSQVMQEKD GSKTIYIVLP 120

YYSLGSLQDS INRRLLEGTF VSEAECVRIM LGVTRGLLCL HDPASRQDNA TSRVNVDAVS 180

MTYSDETAML LEDTPLEMDM LSSNSAGSIA YAHRDITPSN ILFSSDGLPV IGDLGSCSQA 240

DITIENRHQL SELQEWVNDN CTLPYTPPEL LNLKLNQVLS SKVDIWSLGC TFYTLMFGIS 300

PFEREEQIHG ASLTYAINTG KYSFPRNSRF SEGLLSVIKK CIQVDPIQRP TTSQLLNLLQ 360

DLDT 364

Nucleotide Sequence
(FASTA)

ATGATTTCTA TTGTATTGGA ATTGTTCCAG AACTTGTGCT GCTGTCGCGG ATTTTCCGAT 60

GCTACTATTA GGGTAAATGA TAAACGATAT AGGATTCAAC GACTACTTGG AGAAGGTGGA 120

ATGTCCTTTG TGTATTTGGT ACAACTGTCA AAGAATTCTC TGATTATAGA CAACGGCATC 180

GCAACACCAG AATTATACGC ACTAAAGAAG ATTATTTGTC CTAGTGTGGA AAGTATATCC 240

AATGGTATGC GAGAAATTGA AAATTACAAA CGGTTTCAAA GTCCTTATGT TATAAAAAGT 300

ATCGACTCAC AAGTAATGCA GGAAAAAGAT GGGTCAAAAA CAATTTACAT AGTACTACCC 360

TATTATTCAT TAGGGAGTTT ACAAGACTCT ATTAATCGGA GGTTACTCGA GGGCACCTTT 420

GTATCAGAGG CAGAATGCGT AAGGATAATG CTTGGAGTTA CAAGAGGTTT ACTTTGTTTA 480

CATGATCCTG CGTCAAGACA AGATAACGCT ACTTCCAGAG TAAATGTCGA TGCGGTTTCT 540

ATGACTTATA GCGATGAAAC GGCGATGCTC CTAGAAGACA CCCCCTTAGA GATGGACATG 600

CTTTCCTCCA ACTCAGCAGG TTCAATAGCA TATGCACATC GCGATATTAC ACCTTCAAAC 660

ATTTTGTTCT CTTCAGACGG TTTACCAGTA ATTGGTGACC TCGGCTCCTG CTCTCAAGCT 720

GATATAACAA TTGAAAACAG ACATCAACTC AGCGAACTAC AAGAATGGGT CAATGACAAT 780

TGTACGTTGC CATATACTCC ACCAGAACTT CTGAACTTGA AATTAAATCA GGTTTTGAGC 840

TCTAAGGTTG ATATTTGGTC TTTGGGTTGT ACGTTCTATA CTTTAATGTT CGGTATCTCC 900

CCCTTTGAGC GAGAAGAGCA GATACATGGA GCTTCTTTAA CCTACGCTAT AAACACTGGT 960

AAGTACAGTT TCCCGAGAAA TTCCAGATTT TCTGAGGGGC TTTTGAGTGT AATCAAGAAA 1020

TGCATTCAAG TGGATCCTAT ACAAAGGCCT ACTACCAGCC AATTATTAAA TCTTTTACAA 1080

GATTTAGACA CTTGA 1095

Domain Profile

S: 1     vriekvlaeGGfalvylae..........dastgekyalKrilvneeedleeikrEieim  50

         +ri+++l+eGG+++vyl++          +++t+e yalK+i+++++e++++ +rEie++

Q: 30    YRIQRLLGEGGMSFVYLVQlsknsliidnGIATPELYALKKIICPSVESISNGMREIENY  89

         79**************************99******************************

S: 51    kklsghknivklvdssvkeekdngskevlllleyckkgslvdllnkrlekge.lseaeil  109

         k+++ +++++k++ds+v++ekd gsk+++++l+y++ gsl+d++n+rl +g+ +seae++

Q: 90    KRFQ-SPYVIKSIDSQVMQEKD-GSKTIYIVLPYYSLGSLQDSINRRLLEGTfVSEAECV  147

         ****.*****************.9************************************

S: 110   killdvtravaalH............................................al  125

         +i+l+vtr++ +lH                                            a

Q: 148   RIMLGVTRGLLCLHdpasrqdnatsrvnvdavsmtysdetamlledtplemdmlssnsAG  207

         ************************************************************

S: 126   svpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeieknttlsyrs  185

         s++++HRD++++Nil+s++g +v++DlGS+++a++++e++++ls+lqe++++n+tl+y++

Q: 208   SIAYAHRDITPSNILFSSDGLPVIGDLGSCSQADITIENRHQLSELQEWVNDNCTLPYTP  267

         ************************************************************

S: 186   PElidlysnlvideksDiWaLGcllYklcffesPf.......eesvklailngkysiPen  238

         PEl++l+ n+v+++k+DiW+LGc++Y+l+f++sPf       ++s+++ai++gkys+P+n

Q: 268   PELLNLKLNQVLSSKVDIWSLGCTFYTLMFGISPFereeqihGASLTYAINTGKYSFPRN  327

         ************************************************************

S: 239   sryseklkslikkmlevdpeeRptiaqvlell  270

         sr+se l s+ikk+++vdp +Rpt++q+l+ll

Q: 328   SRFSEGLLSVIKKCIQVDPIQRPTTSQLLNLL  359

         ****************************9875

Domain Sequence
(FASTA)

YRIQRLLGEG GMSFVYLVQL SKNSLIIDNG IATPELYALK KIICPSVESI SNGMREIENY 60

KRFQSPYVIK SIDSQVMQEK DGSKTIYIVL PYYSLGSLQD SINRRLLEGT FVSEAECVRI 120

MLGVTRGLLC LHDPASRQDN ATSRVNVDAV SMTYSDETAM LLEDTPLEMD MLSSNSAGSI 180

AYAHRDITPS NILFSSDGLP VIGDLGSCSQ ADITIENRHQ LSELQEWVND NCTLPYTPPE 240

LLNLKLNQVL SSKVDIWSLG CTFYTLMFGI SPFEREEQIH GASLTYAINT GKYSFPRNSR 300

FSEGLLSVIK KCIQVDPIQR PTTSQLLNLL 330

Keyword

ATP-binding; Complete proteome; Kinase; Lipoprotein; Membrane; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Vacuole.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000329	; C:fungal-type vacuole membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006624	; P:vacuolar protein processing

KEGG

sce:YPL236C

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013