EKS-CAE-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	333.3	1.6E-99	15	273	259

Status

Unreviewed

Ensembl Protein

ZC404.9

UniProt Accession

Q23290;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

gck-2

Gene Synonyms/Alias

gck-2; CELE_ZC404.9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ZC404.9	ZC404.9	ZC404.9

Organism

Caenorhabditis elegans

Functional Description

Protein Length

829

Protein Sequence
(FASTA)

MSADVIKRSN PADDYELLQR VGSGTYGEVY KARDIRSDSL AAVKVVKLEA GDNFAVIQQE 60

IMVIRECSHP NIIAYFGSYI RRDRLWIVME YCGGGSLQDI YHLTGPLSEL QIAFVCRETL 120

RGLNYLHNMG KIHRDIKGAN ILLSSSGDVK LADFGVAAQI TATIGKRKSF IGTPYWMAPE 180

VACVEKRGGY GMQCDVWATG ITAIELGECQ PPLFDLHPMQ VLYLMTKSGY KPPHLKDKHR 240

WTPLFHDFVR QCLTKNPKKR PSPEKLLTSH PFVLGSLSAR MTRDLLDKVN GAPTDVYDRM 300

SKTVDDLTEE ESDMDDAPSL LTPDAAPIRI GLPAHLNGLR LDARCLEQLS SSPNTSSESD 360

RRTPTATPRS LNRGYHSERT LPAKEMPLLP DVVGGDALLH CGNGVIHDDD ETLRAPRAPP 420

RTLRAAQKAA AGNSKNRFSS TSIASTPSED GLTTFFGMPL IPKVPMGACF SKVMDRTELK 480

INCAASWVHP LTGAHLLLFG TEQGIYSFDT NCMPDGNLSK IHHRRCSWMF VYADRLTAIQ 540

GNTPYVYRHD LVALTQKNLT LKMSKNLNKI PEKYVPKRLA ITVRMPETRG ALQCTVKRGQ 600

GAQANSLFLC CAVRKTVHLF QWYNPMNQFV LVRSEPIRED IRFPIRPFAL INSRTSDFPE 660

LCIGVGQMSG SNEYQFNMIN FCSSTNNSEL SGDLNSSYGS LADDEMLEVG SMHQIDRDTL 720

CFSFRNKVVL TDLQGFERPK PSIFTFNFHI EYLHVVDGTI LAFHANGVQG RDLKSNLNTQ 780

DLCDVSRLYR VIGDDRVIIL RSQPMSPRNS GDTCDVSLLM GHTDTPIAG 829

Nucleotide Sequence
(FASTA)

ATGAGTGCCG ATGTAATCAA ACGATCAAAT CCGGCAGATG ATTACGAACT TCTGCAACGT 60

GTCGGCTCCG GAACATATGG AGAAGTTTAT AAAGCAAGAG ATATCAGAAG TGATTCACTG 120

GCAGCTGTCA AAGTAGTCAA ACTCGAGGCG GGCGACAATT TTGCAGTAAT CCAGCAGGAG 180

ATTATGGTCA TTAGAGAGTG TTCTCATCCG AATATTATTG CGTACTTTGG AAGTTATATC 240

AGAAGAGACC GATTATGGAT TGTTATGGAG TACTGCGGCG GTGGAAGTCT TCAAGATATC 300

TATCACTTGA CCGGACCACT TTCGGAACTT CAAATCGCCT TCGTGTGCCG AGAAACTTTG 360

CGTGGCTTGA ATTATCTTCA CAATATGGGA AAAATTCATC GAGATATCAA AGGCGCAAAT 420

ATTCTATTAT CTTCAAGCGG TGATGTGAAA TTAGCGGATT TCGGTGTCGC AGCTCAAATT 480

ACAGCTACTA TTGGAAAAAG AAAATCGTTC ATTGGAACTC CGTATTGGAT GGCTCCGGAA 540

GTTGCTTGTG TTGAAAAACG AGGTGGATAC GGGATGCAAT GCGATGTCTG GGCGACAGGA 600

ATCACTGCAA TCGAGCTCGG AGAATGTCAG CCACCACTTT TTGATCTTCA CCCAATGCAG 660

GTTCTCTATC TGATGACAAA AAGTGGTTAT AAGCCACCGC ACCTGAAAGA CAAGCATCGA 720

TGGACTCCGC TATTCCATGA TTTTGTTCGT CAGTGCCTCA CGAAAAATCC GAAAAAGAGA 780

CCTTCACCGG AGAAGCTTCT GACAAGCCAT CCTTTTGTTC TTGGATCACT TTCAGCTAGA 840

ATGACAAGAG ATTTATTGGA TAAAGTTAAC GGAGCACCAA CTGATGTTTA TGATCGAATG 900

TCGAAGACTG TTGATGACTT GACTGAAGAA GAATCAGATA TGGATGATGC TCCTTCACTT 960

CTCACACCGG ATGCTGCACC AATTCGAATC GGCCTGCCTG CTCATCTGAA CGGTTTGAGA 1020

TTAGATGCGA GATGTCTCGA ACAACTATCC TCATCGCCGA ACACTTCGTC AGAATCAGAT 1080

CGGAGGACAC CAACTGCAAC GCCACGAAGT TTGAATCGAG GATATCATTC TGAAAGAACA 1140

CTTCCTGCCA AGGAAATGCC GTTGTTACCA GACGTAGTTG GTGGTGATGC ACTACTTCAC 1200

TGTGGTAACG GAGTAATTCA CGATGATGAT GAAACTCTTC GAGCACCAAG AGCACCTCCG 1260

AGGACGCTTC GCGCGGCTCA GAAAGCTGCT GCTGGAAATT CGAAAAATCG ATTCAGTTCT 1320

ACATCAATTG CTTCAACACC GAGTGAAGAT GGATTAACGA CATTCTTCGG TATGCCATTG 1380

ATTCCAAAGG TTCCGATGGG AGCATGTTTC TCAAAAGTTA TGGATAGAAC TGAGCTGAAA 1440

ATCAATTGTG CCGCCTCATG GGTTCATCCG TTAACCGGTG CTCACCTTCT GTTATTTGGT 1500

ACGGAACAAG GAATTTATTC TTTCGATACG AACTGCATGC CGGATGGAAA TCTATCTAAA 1560

ATCCATCATC GACGTTGCTC ATGGATGTTT GTGTACGCGG ATCGACTAAC AGCTATCCAG 1620

GGAAATACTC CATACGTCTA TCGTCATGAT CTTGTGGCTT TAACGCAGAA AAATTTGACT 1680

CTGAAAATGA GCAAAAATCT GAACAAAATT CCCGAAAAAT ATGTACCAAA ACGATTAGCG 1740

ATTACTGTCA GGATGCCTGA AACACGTGGA GCACTACAGT GTACAGTGAA ACGAGGACAA 1800

GGAGCTCAAG CAAATTCTCT CTTTTTGTGC TGCGCTGTTC GAAAGACTGT TCACCTGTTT 1860

CAGTGGTACA ATCCAATGAA TCAGTTTGTT TTGGTTCGAA GTGAGCCTAT TCGAGAAGAC 1920

ATTCGTTTCC CCATTCGACC ATTTGCATTG ATTAATTCAC GAACATCAGA CTTCCCAGAA 1980

TTATGCATTG GAGTTGGTCA AATGTCTGGA TCAAATGAAT ATCAATTCAA TATGATCAAT 2040

TTCTGCTCAT CAACTAATAA CTCTGAGCTC AGTGGAGATT TAAACTCATC ATACGGAAGT 2100

CTTGCCGATG ACGAAATGCT TGAAGTTGGA AGTATGCATC AAATTGATAG AGATACATTA 2160

TGCTTTTCAT TCCGCAATAA AGTAGTGTTG ACTGATCTAC AGGGATTCGA ACGCCCGAAG 2220

CCGTCGATCT TCACTTTCAA TTTTCACATT GAATATCTAC ACGTCGTCGA TGGAACGATT 2280

CTCGCTTTTC ATGCAAATGG AGTTCAAGGC AGAGATTTGA AAAGTAATCT GAATACTCAG 2340

GATTTGTGCG ATGTATCTCG ATTATATCGT GTGATCGGTG ATGATAGAGT AATAATCCTC 2400

CGATCGCAAC CAATGTCACC CCGAAACTCT GGCGATACTT GTGACGTCAG CTTACTTATG 2460

GGACATACGG ATACTCCAAT CGCTGGATAA 2490

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yell+++g+G++g+vy+ar++++++l+a+k+++le+ ++ + +q+ei v+++++hpni++

Q: 15    YELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIA  74

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s++++++lw+vmey+ gGsl+d+++  l+ +l+E qia ++re+l++L+ylH++++i

Q: 75    YFGSYIRRDRLWIVMEYCGGGSLQDIYH--LTGPLSELQIAFVCRETLRGLNYLHNMGKI  132

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLl+++g+VkL+dfgvaaq+++t  krk+++gtpywmAPEv  +e + gY +

Q: 133   HRDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEkRGGYGM  192

         ***************************************************998899***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

         ++D+w+ GItaiel e +pP++dl+p+++l++++k+   pp+lk+k+++++ f++fv++c

Q: 193   QCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGykPPHLKDKHRWTPLFHDFVRQC  252

         ***********************************98889********************

S: 238   lqknpekRpsasell.khkFl  257

         l+knp+kRps ++ll +h+F+

Q: 253   LTKNPKKRPSPEKLLtSHPFV  273

         ************998467885

Domain Sequence
(FASTA)

YELLQRVGSG TYGEVYKARD IRSDSLAAVK VVKLEAGDNF AVIQQEIMVI RECSHPNIIA 60

YFGSYIRRDR LWIVMEYCGG GSLQDIYHLT GPLSELQIAF VCRETLRGLN YLHNMGKIHR 120

DIKGANILLS SSGDVKLADF GVAAQITATI GKRKSFIGTP YWMAPEVACV EKRGGYGMQC 180

DVWATGITAI ELGECQPPLF DLHPMQVLYL MTKSGYKPPH LKDKHRWTPL FHDFVRQCLT 240

KNPKKRPSPE KLLTSHPFV 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

cel:CELE_ZC404.9

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013