EKS-CAE-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.3	4.1E-104	21	288	268

Status

Reviewed

Ensembl Protein

ZC504.4d

UniProt Accession

Q23356; Q8I4B5; Q8T8M3; Q95ZI7; Q9UAN7; Q9XYC3; Q9XYC4;

Protein Name

Serine/threonine-protein kinase mig-15

Protein Synonyms/Alias

Abnormal cell migration protein 15;

Gene Name

mig-15

Gene Synonyms/Alias

mig-15; ZC504.4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ZC504.4	ZC504.4a	ZC504.4a
ZC504.4	ZC504.4d	ZC504.4d
ZC504.4	ZC504.4c	ZC504.4c
ZC504.4	ZC504.4b	ZC504.4b

Organism

Caenorhabditis elegans

Functional Description

Involved in cell migration and signal transduction.Important in several developmental processes including epidermal development, Q neuroblast migrations and muscle arm targeting. Required with ina-1/pat-3 to stabilize the commissural axons growth cone along a precise direction and are required for the cell to respond appropriately when signaling in the growth cone must change.

Protein Length

1072

Protein Sequence
(FASTA)

MSSSGLDEID LNSLRDPAGI FELIEVVGNG TYGQVYKGRH VKTAQLAAIK IMNINEDEED 60

EIKLEINMLK KHSHHRNVAT YYGAFIKKLP SSTGKHDQLW LVMEFCGSGS ITDLVKNTKG 120

GSLKEEWIAY ICREILRGLY HLHQSKVIHR DIKGQNVLLT DSAEVKLVDF GVSAQLDKTV 180

GRRNTFIGTP YWMAPEVIAC DESPEATYDS RSDLWSLGIT ALEMAEGHPP LCDMHPMRAL 240

FLIPRNPPPK LKRNKKWTKK FETFIETVLV KDYHQRPYTG ALLRHPFIKE QPHEQTIRHS 300

IKEHIDRNRR VKKDDADYEY SGSEDDEPSP NNRGPSMGIR DDSESSSMIP MDNTLQPGAQ 360

QLRRLPQQPA PAPFQYQQSR YVEPRRESSE VKLRAVSSRG AADGPRHSPA SRPRPVSHHQ 420

RSPQQSHPAA PHLADLANYE KRRRSEREER RERERQAHHA MPIARVSASV PAPQQSRKMS 480

EPLLITHVKP EDLDVLASEL SKMGGHHNGR SREESMSPPP PAPPPREASI SSITDTIDVG 540

ELDNGADAEW DDLKDIMMNG EGTLRGPNKP LPPTPTDGEN TLVSDVRRNG NGNSGHGAYK 600

GKKIPEIRPG IISLDDDDSD SDNEEGNEPL MFKPINASSS RGALPDLLPK SPQLRRQIND 660

QTRQMSDDRA DEQPNGFQNS DSRSSIQHSF SNRDREKSFV GYFGGGAGAG GGTVNRPGRP 720

QDINQVQVNV TPNSNGTPAE NDAPEIRKYK KKFSGEILCA ALWGVNLLIG TDSGLMLLDR 780

SGQGKVYPLI SRRRFDQMTV LEGQNILATI SGRKRRIRVY YLSWLRQKIL RTEGAGSANT 840

TEKRNGWVNV GDLQGAIHFK IVRYERIKFL VVGLESSIEI YAWAPKPYHK FMSFKSFGSL 900

SHVPLIVDLT VEDNARLKVL YGSTGGFHAI DLDSAAVYDI YTPAQSGQTT TPHCIVVLPN 960

SNGMQLLLCY DNEGVYVNTY GRMTKNVVLQ WGEMPSSVAY ISTGQIMGWG NKAIEIRSVD 1020

TGHLDGVFMH KKAQKLKFLC ERNDKVFFSS AKGGGSCQIY FMTLNKPGLT NW 1072

Nucleotide Sequence
(FASTA)

ATGTCGTCAT CAGGACTCGA CGAGATTGAT TTGAATTCTC TAAGGGACCC GGCTGGAATC 60

TTCGAGCTAA TTGAGGTTGT TGGAAATGGA ACTTACGGGC AAGTGTATAA GGGTCGACAC 120

GTTAAAACAG CGCAACTTGC TGCAATCAAA ATTATGAATA TCAACGAAGA TGAAGAAGAT 180

GAAATTAAGT TAGAAATTAA TATGCTAAAG AAGCACTCCC ACCACCGGAA CGTAGCCACT 240

TATTATGGTG CTTTCATCAA AAAGCTGCCC TCTTCGACCG GAAAACACGA TCAATTATGG 300

CTGGTAATGG AGTTTTGTGG AAGTGGTTCT ATCACCGATC TTGTAAAAAA CACAAAGGGA 360

GGCTCTTTGA AAGAAGAATG GATTGCATAT ATTTGTAGAG AAATTTTGAG GGGACTTTAC 420

CACTTGCATC AAAGCAAAGT TATCCATCGT GACATAAAAG GTCAAAATGT GCTTCTTACG 480

GACAGTGCTG AGGTGAAGCT GGTAGATTTC GGAGTATCTG CACAACTTGA CAAGACAGTT 540

GGAAGAAGAA ACACATTTAT TGGAACACCA TACTGGATGG CTCCCGAAGT TATTGCATGT 600

GATGAAAGCC CTGAAGCTAC TTATGATTCA CGTTCGGATT TATGGTCTTT GGGAATCACG 660

GCATTAGAAA TGGCGGAAGG TCATCCACCG TTGTGCGATA TGCATCCGAT GAGAGCGTTA 720

TTTTTAATTC CAAGAAATCC GCCGCCAAAG TTGAAAAGAA ATAAGAAGTG GACCAAGAAG 780

TTCGAGACTT TTATTGAGAC TGTACTTGTG AAGGATTACC ATCAAAGGCC CTACACTGGA 840

GCCCTACTTC GTCATCCATT TATCAAAGAA CAACCACATG AGCAAACGAT CCGGCATTCA 900

ATCAAAGAGC ATATTGACCG AAATCGGCGG GTGAAGAAGG ATGATGCAGA CTACGAGTAT 960

TCCGGCAGTG AAGATGATGA ACCATCTCCG AACAATCGTG GTCCTTCAAT GGGCATTCGA 1020

GATGACTCGG AGAGCAGTTC AATGATTCCA ATGGATAACA CATTGCAACC AGGTGCTCAG 1080

CAGCTGAGGA GACTGCCCCA GCAACCAGCA CCAGCTCCAT TCCAATATCA GCAGTCTCGA 1140

TACGTTGAGC CAAGACGAGA ATCATCCGAA GTCAAACTGA GGGCTGTTTC ATCTAGAGGA 1200

GCTGCCGATG GTCCACGTCA TTCGCCAGCA TCAAGGCCAC GGCCCGTGAG TCATCATCAG 1260

CGATCTCCAC AACAATCCCA TCCTGCAGCC CCACACTTGG CGGATTTAGC AAACTATGAA 1320

AAAAGAAGAC GATCGGAACG AGAAGAGCGA CGGGAAAGAG AACGTCAGGC TCACCACGCT 1380

ATGCCGATTG CACGTGTTTC TGCAAGTGTA CCTGCTCCAC AACAGTCTCG AAAAATGTCA 1440

GAACCCCTTC TGATCACTCA TGTAAAACCA GAAGATCTTG ACGTGCTCGC CAGTGAGCTT 1500

TCTAAAATGG GCGGTCATCA CAATGGACGC AGTCGCGAGG AGAGCATGAG CCCACCGCCA 1560

CCGGCGCCAC CACCGCGTGA GGCATCGATC TCGTCTATCA CAGACACGAT TGACGTGGGT 1620

GAATTGGATA ATGGAGCAGA TGCGGAGTGG GACGATTTGA AGGACATTAT GATGAACGGA 1680

GAAGGCACAC TGCGCGGCCC GAATAAGCCG CTTCCGCCAA CACCGACAGA TGGCGAGAAT 1740

ACACTTGTGT CAGATGTGCG TCGCAATGGA AATGGAAATA GTGGCCATGG GGCTTACAAG 1800

GGAAAGAAAA TTCCAGAGAT TCGCCCTGGA ATTATCTCTC TTGACGACGA CGACAGCGAC 1860

TCGGACAACG AGGAAGGCAA CGAGCCCCTT ATGTTCAAAC CAATTAACGC CTCAAGCTCG 1920

CGCGGCGCCC TGCCAGATCT CTTGCCCAAA TCGCCACAAC TCCGCCGTCA AATAAATGAC 1980

CAAACACGCC AGATGAGTGA CGATCGTGCA GATGAGCAAC CAAATGGATT CCAAAACTCT 2040

GACAGCCGTT CATCAATTCA GCATTCATTT TCGAATCGTG ATCGCGAAAA GTCATTTGTT 2100

GGATATTTTG GTGGTGGCGC CGGAGCCGGT GGTGGCACAG TAAATCGACC AGGGAGACCG 2160

CAAGACATTA ACCAAGTTCA AGTTAATGTG ACACCAAATT CTAATGGAAC ACCAGCTGAG 2220

AACGATGCTC CAGAAATCAG GAAGTACAAG AAAAAGTTCA GTGGAGAGAT TTTGTGTGCA 2280

GCTCTCTGGG GAGTTAACTT GCTTATTGGA ACAGACAGTG GACTTATGCT TTTGGATCGA 2340

AGTGGACAAG GAAAAGTTTA CCCGCTCATC AGTCGGAGAA GGTTTGATCA GATGACGGTT 2400

CTCGAGGGAC AAAATATTCT CGCAACAATT TCCGGAAGAA AAAGGAGAAT CAGAGTGTAT 2460

TATTTGAGCT GGCTCCGTCA GAAAATTTTA AGAACAGAGG GTGCTGGAAG CGCCAATACG 2520

ACTGAAAAAA GAAATGGATG GGTTAATGTT GGAGATTTGC AAGGAGCCAT TCATTTCAAA 2580

ATTGTTCGCT ATGAAAGGAT AAAGTTCTTG GTAGTTGGTC TAGAGTCGTC AATTGAGATT 2640

TATGCGTGGG CACCGAAGCC ATACCATAAG TTCATGAGTT TCAAGTCATT CGGATCTTTG 2700

AGTCATGTTC CTTTGATTGT CGACTTGACA GTTGAAGACA ATGCAAGACT CAAGGTTCTT 2760

TATGGATCGA CAGGTGGATT CCATGCAATT GATTTGGATT CTGCAGCGGT CTATGATATT 2820

TATACGCCAG CACAGAGCGG TCAAACTACG ACTCCACATT GCATAGTTGT TCTTCCAAAC 2880

TCCAATGGAA TGCAACTCCT TCTCTGTTAT GACAATGAGG GAGTATATGT TAACACGTAC 2940

GGAAGGATGA CAAAGAATGT AGTCCTGCAA TGGGGAGAAA TGCCAAGCAG TGTGGCGTAC 3000

ATTTCAACGG GTCAGATTAT GGGATGGGGC AACAAGGCGA TTGAGATTCG ATCCGTTGAC 3060

ACTGGCCATT TGGATGGAGT GTTTATGCAC AAGAAAGCTC AGAAGCTGAA ATTCTTGTGT 3120

GAGAGAAATG ATAAAGTATT CTTCTCGTCT GCGAAGGGTG GAGGGTCTTG CCAGATCTAC 3180

TTCATGACCT TAAATAAGCC AGGGTTGACA AATTGGTAA 3219

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++kt +l+aik++n+++ ++++e++ ei++lkk +h +n+

Q: 21    FELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINE-DEEDEIKLEINMLKKHSHhRNVA  79

         899********************************8.9999**********99888****

S: 60    eylesflk........eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaL  111

         +y+++f+k        +++lwlvme++  Gs++dlvk+++  +lkEe+iayi+re+l++L

Q: 80    TYYGAFIKklpsstgkHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGL  139

         ***************99*******************************************

S: 112   eylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEvia  171

          +lH++kviHrdik++n+Llt+++eVkL+dfgv+aql+kt+ +r+t++gtpywmAPEvia

Q: 140   YHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIA  199

         ************************************************************

S: 172   qe...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfsk  228

         ++   e +Yd+++D+wslGIta+e+aeg+pP++d++p++al++i++n+ppklk++kk++k

Q: 200   CDespEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTK  259

         **99999*****************************************************

S: 229   efkefvekclqknpekRpsasellkhkFl  257

         +f++f+e++l k++++Rp +  ll+h+F+

Q: 260   KFETFIETVLVKDYHQRPYTGALLRHPFI  288

         ****************************7

Domain Sequence
(FASTA)

FELIEVVGNG TYGQVYKGRH VKTAQLAAIK IMNINEDEED EIKLEINMLK KHSHHRNVAT 60

YYGAFIKKLP SSTGKHDQLW LVMEFCGSGS ITDLVKNTKG GSLKEEWIAY ICREILRGLY 120

HLHQSKVIHR DIKGQNVLLT DSAEVKLVDF GVSAQLDKTV GRRNTFIGTP YWMAPEVIAC 180

DESPEATYDS RSDLWSLGIT ALEMAEGHPP LCDMHPMRAL FLIPRNPPPK LKRNKKWTKK 240

FETFIETVLV KDYHQRPYTG ALLRHPFI 268

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transducer; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0005083	; F:small GTPase regulator activity
GO:0010171	; P:body morphogenesis
GO:0033563	; P:dorsal/ventral axon guidance
GO:0040035	; P:hermaphrodite genitalia development
GO:0040039	; P:inductive cell migration
GO:0019915	; P:lipid storage
GO:0002119	; P:nematode larval development
GO:0006898	; P:receptor-mediated endocytosis

KEGG

cel:CELE_ZC504.4

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013