EKS-CAE-00255

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00255

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	415.2	1.4E-124	825	1081	257

Status

Reviewed

Ensembl Protein

ZK1067.1b

UniProt Accession

P24348;

Protein Name

Receptor tyrosine-protein kinase let-23

Protein Synonyms/Alias

Lethal protein 23;

Gene Name

let-23

Gene Synonyms/Alias

let-23; kin-7; ZK1067.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ZK1067.1	ZK1067.1c	ZK1067.1c
ZK1067.1	ZK1067.1b	ZK1067.1b
ZK1067.1	ZK1067.1a	ZK1067.1a

Organism

Caenorhabditis elegans

Functional Description

Tyrosine kinase receptor required for the induction ofvulval differentiation. Possible receptor for the inductive signal required for vulval development. Activated by lin-3 and acts by way of let-60 RAS. The lin-3/let-23 pair is a simplified version of the mammalian neuregulin-ERBB network.

Protein Length

1262

Protein Sequence
(FASTA)

MYRGCRRVYG NLEITWIEAN EIKKWRESTN STVDPKNEDS PLKSINFFDN LEEIRGSLII 60

YRANIQKISF PRLRVIYGDE VFHDNALYIH KNDKVHEVVM RELRVIRNGS VTIQDNPKMC 120

YIGDKIDWKE LLYDPDVQKV ETTNSHQHCY QNGKSMAKCH ESCNDKCWGS GDNDCQRVYR 180

SVCPKSCSQC FYSNSTSSYE CCDSACLGGC TGHGPKNCIA CSKYELDGIC IETCPSRKIF 240

NHKTGRLVFN PDGRYQNGNH CVKECPPELL IENDVCVRHC SDGHHYDATK DVRECEKCRS 300

SSCPKICTVD GHLTNETLKN LEGCEQIDGH LIIEHAFTYE QLKVLETVKI VSEYITIVQQ 360

NFYDLKFLKN LQIIEGRKLH NVRWALAIYQ CDDLEELSLN SLKLIKTGAV LIMKNHRLCY 420

VSKIDWSSII TSKGKDNKPS LAIAENRDSK LCETEQRVCD KNCNKRGCWG KEPEDCLECK 480

TWKSVGTCVE KCDTKGFLRN QTSMKCERCS PECETCNGLG ELDCLTCRHK TLYNSDFGNR 540

MECVHDCPVS HFPTQKNVCE KCHPTCYDNG CTGPDSNLGY GGCKQCKYAV KYENDTIFCL 600

QSSGMNNVCV ENDLPNYYIS TYDTEGVIET HCEKCSISCK TCSSAGRNVV QNKCVCKHVE 660

YQPNPSERIC MDQCPVNSFM VPDTNNTVCK KCHHECDQNY HCANGQSTGC QKCKNFTVFK 720

GDIAQCVSEC PKNLPFSNPA NGECLDYDIA SRQRKTRMVI IGSVLFGFAV MFLFILLVYW 780

RCQRIGKKLK IAEMVDMPEL TPIDASVRPN MSRICLIPSS ELQTKLDKKL GAGAFGTVFA 840

GIYYPKRAKN VKIPVAIKVF QTDQSQTDEM LEEATNMFRL RHDNLLKIIG FCMHDDGLKI 900

VTIYRPLGNL QNFLKLHKEN LGAREQVLYC YQIASGMQYL EKQRVVHRDL ATRNVLVKKF 960

NHVEITDFGL SKILKHDADS ITIKSGKVAI KWLAIEIFSK HCYTHASDVW AFGVTCWEII 1020

TFGQSPYQGM STDSIHNFLK DGNRLSQPPN CSQDLYQELL RCWMADPKSR PGFEILYERF 1080

KEFCKVPQLF LENSNKISES DLSAEERFQT ERIREMFDGN IDPQMYFDQG SLPSMPSSPT 1140

SMATFTIPHG DLMNRMQSVN SSRYKTEPFD YGSTAQEDNS YLIPKTKEVQ QSAVLYTAVT 1200

NEDGQTELSP SNGDYYNQPN TPSSSSGYYN EPHLKTKKPE TSEEAEAVQY ENEEVSQKET 1260

CL 1262

Nucleotide Sequence
(FASTA)

ATGTACCGAG GGTGTCGTCG TGTTTATGGA AATCTTGAAA TAACATGGAT AGAAGCAAAT 60

GAAATAAAGA AATGGAGAGA ATCGACGAAT AGCACTGTGG ACCCAAAAAA TGAAGATTCA 120

CCATTGAAAT CAATTAACTT TTTTGATAAT TTAGAGGAGA TTCGAGGAAG CTTAATAATT 180

TATCGTGCGA ATATTCAAAA AATATCATTT CCAAGACTAC GAGTAATCTA CGGAGACGAG 240

GTTTTTCACG ATAATGCATT GTACATTCAT AAAAATGATA AAGTTCACGA AGTTGTGATG 300

AGAGAGTTGA GAGTGATTAG GAATGGAAGT GTCACAATTC AAGACAATCC AAAAATGTGT 360

TACATTGGGG ATAAAATCGA TTGGAAGGAG TTACTGTACG ACCCAGATGT ACAGAAAGTT 420

GAAACTACAA ACTCACATCA ACATTGCTAT CAAAATGGAA AATCAATGGC AAAATGCCAT 480

GAAAGTTGTA ATGATAAATG TTGGGGATCC GGAGACAATG ATTGTCAACG AGTCTACCGT 540

TCCGTATGTC CAAAATCTTG TTCTCAGTGT TTCTACTCGA ACTCTACAAG TTCATACGAA 600

TGTTGTGACT CGGCTTGTCT TGGAGGATGT ACAGGTCACG GACCAAAAAA TTGCATTGCC 660

TGCAGTAAAT ATGAATTGGA TGGAATCTGT ATCGAAACGT GCCCATCGCG AAAAATTTTC 720

AATCACAAAA CAGGACGATT AGTTTTTAAC CCAGACGGAA GATACCAAAA TGGAAATCAT 780

TGTGTGAAAG AATGCCCTCC TGAACTTCTA ATCGAAAACG ATGTATGTGT TCGTCACTGC 840

TCAGATGGTC ACCATTATGA TGCTACAAAA GATGTTAGAG AGTGTGAAAA ATGCAGAAGT 900

TCCAGCTGTC CAAAAATTTG CACGGTCGAT GGACATCTGA CAAACGAGAC ACTTAAAAAC 960

TTGGAAGGCT GCGAACAAAT TGATGGTCAT TTGATAATAG AGCATGCATT CACATACGAA 1020

CAACTAAAAG TCTTGGAGAC AGTGAAAATT GTTAGCGAGT ACATCACGAT TGTTCAGCAA 1080

AACTTCTATG ACTTAAAGTT TCTCAAAAAT CTACAAATCA TTGAAGGCCG AAAACTTCAC 1140

AATGTAAGAT GGGCTCTCGC AATTTATCAA TGCGATGACT TGGAAGAACT GAGCTTAAAC 1200

TCATTGAAAC TTATAAAAAC TGGAGCTGTA TTAATAATGA AAAATCATCG ATTGTGTTAT 1260

GTGTCGAAAA TTGATTGGTC ATCAATTATC ACTTCAAAGG GAAAAGATAA CAAACCCTCA 1320

TTGGCAATTG CTGAAAATAG GGATAGCAAA CTGTGTGAAA CTGAACAGAG AGTTTGTGAT 1380

AAAAACTGCA ATAAACGTGG TTGTTGGGGC AAGGAACCAG AGGACTGTCT CGAGTGTAAG 1440

ACCTGGAAAA GTGTTGGGAC GTGTGTTGAG AAATGTGACA CGAAAGGATT TCTGCGCAAC 1500

CAGACATCAA TGAAATGCGA AAGATGTTCT CCGGAATGTG AAACCTGCAA CGGTCTAGGT 1560

GAACTGGATT GTCTCACTTG CAGACATAAA ACTCTCTACA ATTCGGATTT CGGTAATCGT 1620

ATGGAATGTG TCCACGATTG TCCAGTTTCA CACTTTCCGA CGCAGAAAAA TGTATGCGAA 1680

AAGTGTCATC CGACGTGTTA TGATAATGGA TGTACTGGAC CTGACTCAAA CCTAGGCTAT 1740

GGAGGATGTA AGCAGTGCAA ATACGCTGTA AAATATGAAA ATGATACAAT ATTCTGCTTA 1800

CAATCATCTG GAATGAACAA TGTGTGTGTG GAAAATGACT TGCCTAACTA TTACATTTCA 1860

ACATATGATA CCGAAGGAGT CATTGAGACT CACTGCGAAA AATGTTCAAT TTCCTGCAAA 1920

ACATGTAGTT CAGCTGGTCG CAATGTTGTT CAGAACAAGT GTGTTTGCAA GCATGTTGAA 1980

TATCAACCTA ATCCTTCGGA AAGAATTTGT ATGGATCAGT GTCCAGTGAA CAGTTTTATG 2040

GTTCCCGACA CAAATAACAC GGTCTGTAAA AAATGTCATC ATGAATGTGA TCAGAACTAT 2100

CATTGTGCAA ATGGTCAATC AACTGGATGC CAAAAATGTA AAAACTTTAC GGTTTTCAAG 2160

GGAGATATTG CTCAATGCGT CAGCGAATGC CCAAAGAATC TTCCATTTTC GAATCCGGCA 2220

AATGGAGAAT GTTTGGACTA CGATATTGCA TCAAGACAGC GAAAAACAAG AATGGTTATT 2280

ATTGGAAGCG TGTTATTTGG ATTTGCAGTG ATGTTCTTGT TCATTTTGCT CGTCTACTGG 2340

AGATGTCAAC GTATTGGTAA AAAACTGAAA ATCGCTGAAA TGGTTGACAT GCCTGAACTA 2400

ACTCCAATTG ATGCCAGTGT TCGACCAAAC ATGTCTAGAA TTTGCCTCAT TCCATCATCC 2460

GAGCTGCAAA CCAAACTAGA CAAAAAGCTG GGAGCCGGAG CATTCGGAAC TGTCTTTGCT 2520

GGAATTTACT ATCCAAAGCG AGCAAAGAAT GTTAAAATCC CGGTTGCAAT CAAAGTATTC 2580

CAAACAGATC AAAGTCAAAC TGATGAAATG TTGGAAGAAG CTACGAATAT GTTCAGATTG 2640

AGACACGATA ATTTGCTCAA GATTATTGGA TTCTGTATGC ACGATGATGG TTTGAAAATT 2700

GTCACTATCT ACAGACCTCT CGGAAATCTT CAAAACTTTT TGAAACTTCA CAAGGAAAAT 2760

TTGGGTGCAC GAGAACAAGT ATTATATTGT TATCAAATTG CATCTGGAAT GCAATATTTA 2820

GAGAAACAGC GAGTTGTTCA CAGAGATTTG GCAACAAGAA ATGTTCTTGT GAAGAAGTTC 2880

AATCACGTGG AAATCACTGA TTTTGGTCTC TCTAAAATTC TGAAACATGA CGCCGACTCA 2940

ATCACTATCA AATCTGGAAA AGTTGCAATC AAATGGCTTG CGATCGAAAT CTTCTCCAAA 3000

CATTGTTACA CCCATGCTTC TGATGTTTGG GCATTTGGAG TCACATGTTG GGAGATTATA 3060

ACATTTGGAC AAAGTCCGTA TCAAGGAATG TCGACTGATA GTATTCATAA TTTCTTGAAA 3120

GATGGAAACC GTCTTTCCCA GCCACCAAAC TGCTCTCAAG ACTTGTATCA AGAGCTTCTG 3180

AGATGTTGGA TGGCGGATCC AAAGTCTCGT CCTGGTTTTG AAATATTATA TGAAAGATTT 3240

AAAGAATTCT GTAAGGTTCC CCAACTTTTC CTGGAAAATT CCAACAAGAT TTCTGAATCT 3300

GATTTGTCAG CTGAAGAACG TTTTCAAACG GAAAGAATCC GAGAAATGTT TGATGGAAAT 3360

ATCGATCCAC AGATGTACTT TGATCAAGGA AGTTTACCAA GTATGCCAAG TTCTCCAACT 3420

TCTATGGCAA CGTTCACAAT TCCACATGGT GATCTGATGA ATCGAATGCA ATCAGTAAAC 3480

TCATCTAGGT ACAAAACGGA GCCTTTTGAT TATGGGTCAA CCGCACAGGA AGATAATTCA 3540

TATCTTATTC CAAAAACCAA AGAAGTTCAG CAGTCAGCAG TTTTGTATAC AGCTGTTACA 3600

AATGAAGATG GTCAAACCGA GCTATCCCCA TCAAATGGCG ATTACTACAA CCAACCAAAC 3660

ACTCCTTCAT CTTCCTCTGG ATATTACAAT GAACCACATC TCAAAACTAA AAAACCTGAA 3720

ACATCAGAAG AGGCTGAAGC AGTTCAATAT GAAAATGAAG AAGTATCACA AAAGGAAACT 3780

TGTCTTTAA 3789

Domain Profile

S: 2     kklkvlGsGafGtvykGiwipe.genvkipvaikvleektgkkankelldealvlasldh  60

         k +k+lG+GafGtv++Gi++p+ ++nvkipvaikv++  t++++++e+l+ea+++++l+h

Q: 825   KLDKKLGAGAFGTVFAGIYYPKrAKNVKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRH  882

         789******************999************9..*********************

S: 61    anlvrllglclsst.lqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsylee  119

         +nl++++g+c++++ l++vt+++plG+l+++++ hk++lG++e++ +c+qia+Gm+yle+

Q: 883   DNLLKIIGFCMHDDgLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEK  942

         ************999*********************************************

S: 120   krlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrk  179

         +r+vhrdla+rnvlvk++nhv+itdfGl+k+l++d++++++++gkv+ikwla+e+++k++

Q: 943   QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC  1002

         ************************************************************

S: 180   ythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkc  239

         yth+sdvw++Gvt+we++tfG++py+g+++++i+++l++G+rl+qpp+c++d+y++l++c

Q: 1003  YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRC  1062

         ************************************************************

S: 240   wmidaesrpkfkelaeefs  258

         wm+d++srp f++l+e+f+

Q: 1063  WMADPKSRPGFEILYERFK  1081

         *****************96

Domain Sequence
(FASTA)

KLDKKLGAGA FGTVFAGIYY PKRAKNVKIP VAIKVFQTDQ SQTDEMLEEA TNMFRLRHDN 60

LLKIIGFCMH DDGLKIVTIY RPLGNLQNFL KLHKENLGAR EQVLYCYQIA SGMQYLEKQR 120

VVHRDLATRN VLVKKFNHVE ITDFGLSKIL KHDADSITIK SGKVAIKWLA IEIFSKHCYT 180

HASDVWAFGV TCWEIITFGQ SPYQGMSTDS IHNFLKDGNR LSQPPNCSQD LYQELLRCWM 240

ADPKSRPGFE ILYERFK 257

Keyword

ATP-binding; Cell membrane; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0016323	; C:basolateral plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005006	; F:epidermal growth factor-activated receptor activity
GO:0030539	; P:male genitalia development
GO:0002119	; P:nematode larval development
GO:0030728	; P:ovulation
GO:0040026	; P:positive regulation of vulval development

KEGG

cel:CELE_ZK1067.1

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 7.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013