EKS-CAE-00378

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00378

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PDHK	181.1	1.5E-53	237	358	122

Status

Reviewed

Ensembl Protein

ZK370.5.1

UniProt Accession

Q02332;

Protein Name

Probable [pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial

Protein Synonyms/Alias

Pyruvate dehydrogenase kinase;

Gene Name

pdhk-2

Gene Synonyms/Alias

pdhk-2; ZK370.5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ZK370.5	ZK370.5.2	ZK370.5.2
ZK370.5	ZK370.5.1	ZK370.5.1

Organism

Caenorhabditis elegans

Functional Description

Inhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity).

Protein Length

401

Protein Sequence
(FASTA)

MRFSRKLLGP FVGSLAKKLD YYSQFQPSSL TIQQYLDFGR IGTSANSYTF LKNELLVRLA 60

NIMQEFTLLP PKLLQMPSSK MVSNWYAESF EDLLLFEASD SSPEQVARFN DQLTVVLKRH 120

AHVVETMAEG LIELRESDGV DIASEKGIQY FLDRFYINRI SIRMLQNQHL VVFGNVLPES 180

PRHVGCIDPA CDVESVVYDA FENARFLCDR YYLTSPSMKL EMHNAVEKGK PISIVAVPSH 240

LYHMMFELFK NAMRATVEYH GVDDDLPDIK VYVVKGQEDL SIKICDRGGG VSRTILERLY 300

NYMYSTAPPP PRDGTQAPLA GYGYGLPLSR LYARYFLGDL FLVSMEGHGT DACIYLKAVP 360

VEASEVLPIY STSSRRNLTM GPQVADWSHH VPGQGNRPAQ S 401

Nucleotide Sequence
(FASTA)

ATGCGCTTTT CGCGGAAGTT ACTAGGCCCT TTCGTGGGTT CATTGGCCAA GAAACTCGAT 60

TATTATAGTC AATTTCAACC TTCATCACTT ACAATTCAAC AATATTTGGA TTTCGGTCGA 120

ATAGGAACAT CAGCAAATTC ATACACATTT TTGAAAAATG AGCTTCTCGT TCGTTTGGCG 180

AATATTATGC AGGAATTCAC ACTTCTTCCA CCAAAGCTTC TTCAAATGCC AAGTTCAAAA 240

ATGGTATCAA ATTGGTATGC TGAGAGTTTC GAGGATCTTC TTTTGTTCGA GGCATCTGAT 300

TCATCTCCAG AGCAAGTTGC AAGATTCAAT GATCAGTTAA CAGTCGTACT GAAAAGACAC 360

GCACATGTCG TCGAAACAAT GGCTGAAGGA TTGATTGAAC TTCGAGAATC GGATGGAGTA 420

GATATTGCAA GTGAAAAAGG AATTCAATAT TTCTTGGATC GATTTTACAT CAACAGAATT 480

TCCATTCGTA TGCTTCAAAA TCAACATCTG GTTGTATTCG GAAATGTTCT CCCAGAAAGT 540

CCTCGTCATG TTGGATGTAT TGATCCTGCC TGTGATGTGG AAAGTGTAGT GTACGATGCT 600

TTTGAAAATG CTCGATTTCT ATGTGATCGA TACTACTTGA CAAGTCCATC AATGAAGCTT 660

GAAATGCACA ATGCCGTTGA AAAAGGAAAA CCAATATCGA TTGTCGCCGT ACCAAGTCAT 720

CTCTATCACA TGATGTTCGA ACTGTTTAAG AATGCAATGA GAGCGACAGT TGAATATCAT 780

GGAGTTGATG ATGATCTTCC AGATATTAAA GTTTATGTAG TCAAAGGACA AGAGGATTTA 840

TCTATTAAGA TTTGTGATCG TGGAGGAGGT GTATCCAGAA CTATTCTCGA ACGTCTCTAC 900

AACTACATGT ACTCAACAGC TCCACCACCG CCACGTGATG GAACACAAGC TCCTTTGGCT 960

GGTTACGGAT ACGGACTGCC ACTATCTCGA CTATACGCTC GGTATTTCCT TGGTGACCTC 1020

TTTTTGGTTT CCATGGAAGG ACATGGAACG GATGCATGTA TCTACTTGAA AGCTGTACCA 1080

GTTGAGGCTA GTGAAGTACT CCCAATTTAT AGTACTTCTT CGCGTCGAAA TTTGACAATG 1140

GGACCACAAG TAGCTGATTG GTCGCATCAT GTTCCTGGTC AAGGAAATCG TCCAGCTCAA 1200

TCATGA 1206

Domain Profile

S: 2     vpshlyyllfellknamratveshedkkvlpdvkvlvalgkedliikisdrGGGvplrki  61

         vpshly+++fel+knamratve h   + lpd+kv v++g+edl+iki drGGGv++  +

Q: 237   VPSHLYHMMFELFKNAMRATVEYHGVDDDLPDIKVYVVKGQEDLSIKICDRGGGVSRTIL  296

         8***********************************************************

S: 62    drlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdaviy  121

         +rl++ymystap p +d   +aplaG+GyGlp+srlya+y+ Gdl l+s+eG Gtda iy

Q: 297   ERLYNYMYSTAPPPPRDG-TQAPLAGYGYGLPLSRLYARYFLGDLFLVSMEGHGTDACIY  355

         **************9995.568**************************************

S: 122   lka  124

lka

Q: 356   LKA  358

*97

Domain Sequence
(FASTA)

VPSHLYHMMF ELFKNAMRAT VEYHGVDDDL PDIKVYVVKG QEDLSIKICD RGGGVSRTIL 60

ERLYNYMYST APPPPRDGTQ APLAGYGYGL PLSRLYARYF LGDLFLVSME GHGTDACIYL 120

KA 122

Keyword

ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005759	; C:mitochondrial matrix
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004740	; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0008340	; P:determination of adult lifespan
GO:0006006	; P:glucose metabolic process

KEGG

cel:CELE_ZK370.5

;

InterPros

IPR003594	; ATPase-like_ATP-bd.
IPR018955	; BCDHK/PDK_N.
IPR005467	; Sig_transdc_His_kinase_core.

Pfam

PF10436	; BCDHK_Adom3; 1.
PF02518	; HATPase_c; 1.

SMARTs

SM00387

; HATPase_c; 1.

Prosites

PS50109

; HIS_KIN; 1.

Prints

Created Date

20-Feb-2013