EKS-CAE-00173

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00173

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	479.3	3.9E-144	36	290	255

Status

Reviewed

Ensembl Protein

ZK909.2g

UniProt Accession

P21137; O18310; O18311;

Protein Name

cAMP-dependent protein kinase catalytic subunit

Protein Synonyms/Alias

PKA C;

Gene Name

kin-1

Gene Synonyms/Alias

kin-1; ZK909.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ZK909.2	ZK909.2b	ZK909.2b
ZK909.2	ZK909.2a	ZK909.2a
ZK909.2	ZK909.2j.1	ZK909.2j.1
ZK909.2	ZK909.2d	ZK909.2d
ZK909.2	ZK909.2c	ZK909.2c
ZK909.2	ZK909.2j.2	ZK909.2j.2
ZK909.2	ZK909.2h.1	ZK909.2h.1
ZK909.2	ZK909.2m	ZK909.2m
ZK909.2	ZK909.2h.2	ZK909.2h.2
ZK909.2	ZK909.2i	ZK909.2i
ZK909.2	ZK909.2k	ZK909.2k
ZK909.2	ZK909.2l	ZK909.2l
ZK909.2	ZK909.2e	ZK909.2e
ZK909.2	ZK909.2f	ZK909.2f
ZK909.2	ZK909.2g	ZK909.2g

Organism

Caenorhabditis elegans

Functional Description

Protein Length

343

Protein Sequence
(FASTA)

MGSMVFIVKE FLDKAREDFK QRWENPAQNT ACLDDFDRIK TLGTGSFGRV MLVKHKQSGN 60

YYAMKILDKQ KVVKLKQVEH TLNEKRILQA IDFPFLVNMT FSFKDNSNLY MVLEFISGGE 120

MFSHLRRIGR FSEPHSRFYA AQIVLAFEYL HSLDLIYRDL KPENLLIDST GYLKITDFGF 180

AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL IYEMAAGYPP FFADQPIQIY 240

EKIVSGKVKF PSHFSNELKD LLKNLLQVDL TKRYGNLKNG VADIKNHKWF GSTDWIAIYQ 300

KKIEAPFLPK CRGPGDASNF DDYEEEPLRI SGTEKCAKEF AEF 343

Nucleotide Sequence
(FASTA)

ATGGGATCCA TGGTGTTCAT TGTCAAAGAA TTCCTGGACA AGGCACGCGA AGACTTCAAA 60

CAACGATGGG AGAATCCGGC TCAGAACACG GCGTGTCTTG ACGACTTTGA TAGGATAAAA 120

ACCCTTGGAA CCGGATCATT CGGGCGCGTG ATGCTTGTGA AGCATAAGCA GTCGGGCAAC 180

TATTATGCCA TGAAAATTCT AGACAAACAA AAGGTTGTAA AACTCAAGCA AGTGGAGCAC 240

ACGTTGAACG AAAAGCGCAT TCTCCAGGCT ATCGATTTTC CGTTTTTGGT GAACATGACG 300

TTCTCTTTCA AGGACAACTC CAACTTGTAC ATGGTGCTCG AATTCATCTC GGGAGGTGAG 360

ATGTTCTCAC ATTTACGCCG AATCGGACGT TTCTCCGAGC CCCACTCGCG TTTCTACGCC 420

GCTCAAATTG TGCTTGCCTT TGAGTACCTT CACTCCTTAG ATCTCATCTA TCGTGATCTG 480

AAACCCGAGA ACTTGCTTAT CGATTCCACT GGATATCTAA AGATCACCGA TTTCGGATTT 540

GCGAAACGTG TCAAAGGACG AACGTGGACA TTGTGCGGCA CACCAGAATA CTTGGCACCC 600

GAGATTATTT TGTCAAAAGG ATACAATAAG GCTGTCGATT GGTGGGCACT TGGTGTGTTG 660

ATCTACGAAA TGGCCGCCGG TTATCCGCCG TTCTTTGCCG ATCAGCCGAT TCAAATTTAT 720

GAGAAGATTG TGTCAGGAAA AGTGAAATTC CCGTCGCACT TCTCGAATGA GTTGAAAGAC 780

TTGCTGAAGA ATTTGCTCCA AGTTGATCTT ACAAAGCGAT ACGGTAACCT GAAAAATGGA 840

GTTGCCGATA TCAAAAATCA CAAGTGGTTT GGAAGTACCG ACTGGATTGC CATCTATCAG 900

AAGAAGATCG AAGCACCGTT CCTTCCAAAA TGCCGTGGCC CTGGCGACGC ATCTAACTTT 960

GACGACTACG AGGAAGAGCC GCTTCGTATC TCGGGCACCG AGAAATGCGC CAAAGAGTTT 1020

GCCGAGTTTT AA 1032

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         f+r+ktlGtGsfGrv+lv++k+s++yya+k+l+k+kvvklkqveh+ nekr+l+a++fpf

Q: 36    FDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPF  95

         789*********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lv++++sfkd+snly+vle+++GGe+fs+lr+++rfse+++rfyaa+ivla+eylhsldl

Q: 96    LVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDL  155

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gy+k+tdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 156   IYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  215

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk+kfps++s++lkdllk+llqvdltkr+g

Q: 216   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLKNLLQVDLTKRYG  275

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv dik+hkwf

Q: 276   NLKNGVADIKNHKWF  290

         **************9

Domain Sequence
(FASTA)

FDRIKTLGTG SFGRVMLVKH KQSGNYYAMK ILDKQKVVKL KQVEHTLNEK RILQAIDFPF 60

LVNMTFSFKD NSNLYMVLEF ISGGEMFSHL RRIGRFSEPH SRFYAAQIVL AFEYLHSLDL 120

IYRDLKPENL LIDSTGYLKI TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVKFPSHFS NELKDLLKNL LQVDLTKRYG 240

NLKNGVADIK NHKWF 255

Keyword

Alternative splicing; ATP-binding; cAMP; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005952	; C:cAMP-dependent protein kinase complex
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0002009	; P:morphogenesis of an epithelium
GO:0002119	; P:nematode larval development
GO:0018991	; P:oviposition
GO:1900195	; P:positive regulation of oocyte maturation

KEGG

cel:CELE_ZK909.2

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013