※ PKN family introduction

    PKN, also known as protein kinase C related kinase, belong to the AGC family. PKNs are Serine/Threonine protein kinases which share a C-terminal catalytic domain homologous to PKC members and a N-terminal unique regulatory region containing antiparallel coiled-coil domains (ACC domains). AGC domains act as binding interface associating with others proteins, including anchoring protein CG-NAP. Between the C-terminal and N-terminal region, a C2-like region can be found in PKNs, which function as an auto-inhibitory region. PKN localizes primarily in the cytosolic fraction and involved in a variety of cellular processes, including cytoskeletal regulation, cell adhesion, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the cell nucleus and tumorigenesis (1).

Reference
1. Mukai, H. (2003) The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J Biochem, 133, 17-27. PMID: 12761194