※ SGK family introduction

    SGK are Serine/threonine-protein kinase and belong to AGC group. Three genes encoding SGKs have been identified, SGK1, SGK2 and SGK3. SGK1 is most intensively studied among SGK family kinases. This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Studies show that SGK1 is important in activating certain potassium, sodium and chloride channels. In hepatocytes, the expression of SGK1 is stimulated by transforming growth factor-beta (TGF-beta) which is implicated in pathophysiology of diabetic complications. During osmotic stress, SGK1 can regulate the myo-inositol transporter. In addition, Deregulated expression of SGK1 has been show to be involved in cases of infertility or recurrent miscarriage in humans. Several proteins have been identified to interact with SGK, including Sodium-hydrogen exchange regulatory cofactor 2, Phosphoinositide-dependent kinase-1, Karyopherin alpha, NEDD4 and MAPK7, which is important in varieties of cellular functions (1).

Reference
1. Wikipdia Annotation: SGK