※ BCR family introduction

    BCR (breakpoint cluster region) kinases belong to atypical kinase group, and the kinase domains share no significant sequence with ePK. BCR can be mapped on chromosome 22 in human genome and can form a fusion gene with Abl from chromosome 9. This reciprocal translocation event will lead to an aberrant chromosome Ph formation which is responsible for the chronic myeloid leukaemia (CML). The normal BCR also possess the kinase activity and can auto- and trans-phosphorylate serine, threonine and tyrosine residues. Sequence analysis shows that BCR contains a protein kinase domain in N-terminal, followed by a SH2 domain and a GEF domain, a GTPase activity (GAP) domain is in C-terminal. BCR has been found involved in CML and many important signaling pathways. The identified substrates include 14-3-3 Tau, MLLT4 and PPARg (1).

Reference
1. Clokie, S.J., Cheung, K.Y., Mackie, S., Marquez, R., Peden, A.H. and Aitken, A. (2005) BCR kinase phosphorylates 14-3-3 Tau on residue 233. FEBS J, 272, 3767-3776. PMID: 16045749