Protein Kinase Classification:      Atypical      FAST

※ FAST family introduction

    FAST (Fas-activated Serine/Threonine) kinase can catalyze the phosphate group transfer from ATP to Fas-activated Serine/Threonine protein. TIA1 is substrate of FAST kinase, and the phosphorylation will lead to inclusion of FAS exon6, which will produce an mRNA encoding a pro-apoptotic form of teh receptor (1). Since the overall sequence of FAST shares no similarity with ePK, FAST is classified into "Atypical Protein Kinase" group (2).

Reference
1. UniProt Annotation: FASTK_HUMAN
2. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243

Atypical FAST in eukaryotes:

Ailuropoda melanoleuca (1)Anolis carolinensis (1)Bos taurus (1)
Callithrix jacchus (1)Canis familiaris (1)Danio rerio (1)
Dipodomys ordii (1)Equus caballus (1)Felis catus (1)
Gasterosteus aculeatus (1)Gorilla gorilla (1)Homo sapiens (1)
Ictidomys tridecemlineatus (1)Latimeria chalumnae (1)Loxodonta africana (1)
Macaca mulatta (1)Mus musculus (1)Mustela putorius furo (1)
Myotis lucifugus (1)Nomascus leucogenys (1)Oreochromis niloticus (1)
Ornithorhynchus anatinus (1)Oryctolagus cuniculus (1)Otolemur garnettii (1)
Pan troglodytes (1)Petromyzon marinus (1)Pongo abelii (1)
Procavia capensis (1)Rattus norvegicus (1)Sus scrofa (1)
Taeniopygia guttata (1)Takifugu rubripes (1)Tarsius syrichta (1)
Tetraodon nigroviridis (1)Tursiops truncatus (1)Xiphophorus maculatus (1)