Protein Kinase Classification:      Atypical      TIF1

※ TIF1 family introduction

    TIF1, Transcriptional Intermediary Factor 1, contains three members in human genome, TIF1a, TIF1b and TIF1g, and belong to atypical protein kinase group (1). The autophosphorylation activity of TIF1a has been detected in immunopurified, bacculovirus-produced protein. TIFs participate in transcriptional machinery and may mediate the phosphorylation of several TATA-associated factors. Bromodomains are also found in TIFs, which are present in BRD kinase family, which suggest that bromodomain is associated with kinase activity (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikipedia annotation: TIF1.


Atypical TIF1 in eukaryotes:

Ailuropoda melanoleuca (1)Anolis carolinensis (2)Bos taurus (2)
Callithrix jacchus (3)Canis familiaris (3)Cavia porcellus (3)
Ciona intestinalis (1)Danio rerio (1)Drosophila melanogaster (1)
Echinops telfairi (1)Equus caballus (3)Erinaceus europaeus (1)
Felis catus (3)Gallus gallus (2)Gasterosteus aculeatus (1)
Gorilla gorilla (2)Homo sapiens (3)Ictidomys tridecemlineatus (3)
Latimeria chalumnae (2)Loxodonta africana (3)Macaca mulatta (3)
Macropus eugenii (1)Meleagris gallopavo (2)Monodelphis domestica (2)
Mus musculus (3)Mustela putorius furo (2)Myotis lucifugus (3)
Nomascus leucogenys (2)Oreochromis niloticus (1)Ornithorhynchus anatinus (3)
Oryctolagus cuniculus (3)Oryzias latipes (1)Otolemur garnettii (2)
Pan troglodytes (3)Pelodiscus sinensis (3)Petromyzon marinus (1)
Pongo abelii (3)Procavia capensis (1)Pteropus vampyrus (1)
Rattus norvegicus (3)Sarcophilus harrisii (3)Sorex araneus (1)
Sus scrofa (1)Taeniopygia guttata (2)Takifugu rubripes (1)
Tarsius syrichta (1)Tetraodon nigroviridis (1)Tursiops truncatus (2)
Xenopus tropicalis (3)Xiphophorus maculatus (1)