※ CASK family introduction

    CASK (Calcium/calmodulin-dependent serine protein kinase) belongs to CAMK family. CASK consists of an N-terminal CaM-kinase domain and a C-terminal set of domains which is typical MAGUKs, including an L27 domain, an SH3 domain, and a C-terminal guanylate kinase domain. The PDZ domain binds to neurexins, syndecans, and SynCAMs, putative synaptic cell-adhesion molecules. CASK also interacts with protein-4.1 Ca2+ channels, K2+ channels, CASKins and PARKIN. In addition, CASK also acts as a nuclear transcription factor. Studies also show that CASK can interact with CAMK2 and regulation its phosphorylation states (1).

Reference
1. Mukherjee, K., Sharma, M., Urlaub, H., Bourenkov, G.P., Jahn, R., Sudhof, T.C. and Wahl, M.C. (2008) CASK Functions as a Mg2+-independent neurexin kinase. Cell, 133, 328-339. PMID: 18423203