Protein Kinase Classification:      CAMK      PSK

※ PSK family introduction

    PSK belong to CAMK family, two genes encoding the PSKs have been identified in human genome which are known as PSKH1 and PSKH2. PSKH1 have been shown to targets in SFC (splicing factor compartments) through its kinase catalytic domain and C-terminal domains. Migration of PSKH1-FLAG into SFCs is enhanced during co-expression of T7-tagged ASF/SF2 and others members of SR protein family. In addition, overexpression of PSKH1 have been reported to have an important affects on splicing of an E1A minigene (1).

Reference
1. Brede, G., Solheim, J. and Prydz, H. (2002) PSKH1, a novel splice factor compartment-associated serine kinase. Nucleic Acids Res, 30, 5301-5309. PMID: 12466556

CAMK PSK in eukaryotes:

Ailuropoda melanoleuca (2)Anolis carolinensis (1)Bos taurus (1)
Caenorhabditis elegans (1)Callithrix jacchus (2)Canis familiaris (2)
Cavia porcellus (2)Ciona intestinalis (1)Ciona savignyi (1)
Danio rerio (2)Dasypus novemcinctus (2)Dipodomys ordii (2)
Echinops telfairi (1)Equus caballus (2)Erinaceus europaeus (2)
Felis catus (2)Gadus morhua (1)Gallus gallus (1)
Gasterosteus aculeatus (2)Gorilla gorilla (2)Homo sapiens (2)
Ictidomys tridecemlineatus (2)Latimeria chalumnae (2)Loxodonta africana (2)
Macaca mulatta (2)Macropus eugenii (2)Meleagris gallopavo (1)
Microcebus murinus (2)Monodelphis domestica (2)Mus musculus (1)
Mustela putorius furo (2)Myotis lucifugus (1)Nomascus leucogenys (2)
Oreochromis niloticus (2)Ornithorhynchus anatinus (2)Oryctolagus cuniculus (2)
Oryzias latipes (1)Otolemur garnettii (2)Pan troglodytes (2)
Pelodiscus sinensis (1)Pongo abelii (2)Procavia capensis (1)
Pteropus vampyrus (1)Sarcophilus harrisii (2)Sorex araneus (1)
Taeniopygia guttata (1)Takifugu rubripes (2)Tarsius syrichta (1)
Tetraodon nigroviridis (2)Tupaia belangeri (2)Tursiops truncatus (2)
Vicugna pacos (1)Xenopus tropicalis (2)Xiphophorus maculatus (1)