Protein Kinase Classification: CMGC RCK※ RCK family introduction RCK family is composed of two subfamilies, known as MOK and MAK subfamily. MAK subfamily member MAK is essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. MAK can mediate the phosphorylation of FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. MAK may also play a role in chromosomal stability in prostate cancer cells. MOK family member is able to phosphorylate several exogenous substrates andto undergo autophosphorylation (1).
Reference
1. UniProt Annotation: MAK_HUMAN
CMGC RCK in eukaryotes:
1. UniProt Annotation: MAK_HUMAN
CMGC RCK in eukaryotes: