※ Aur family introduction

    Aurora kinases are classified into "Other" group. Three members have been identified in human genome, AurA, AurB and AurC. Sequence analysis show that Aur kinases contain a conserved kinase catalytic domain flanked by N-terminal and C-terminal regulatory sequence. AurA gene is located within the chromosome locus 20q13, which is a frequently detected in human breast tumors, and AurA is essential for the proper progression through mitosis. AurB is a chromosome passenger involved in cytokinesis and chromosome architecture and AurC plays a role in spermatogenesis at the time when cells assemble the two meiotic spindles, AurC can also cooperates with AurB to regulate mitotic chromosome dynamics. AurA has been reported to be a good marker of tumor progression and prognosis, which can be applied on disease diagnosis and treatment (1).

Reference
1. Bolanos-Garcia, V.M. (2005) Aurora kinases. Int J Biochem Cell Biol, 37, 1572-1577. PMID: 15896667