※ BUB family introduction

    BUB family contains two serin/threonine protein kinases: BUB1A (BUB1) and BUB1B. BUB kinases comprise a conserved N-terminal region, followed by a non-conserved region and a kinase catalytic domain in C-terminal. N-terminal region is responsible for binding to mitotic kinetochore protein blinkin. Human BUB1A accumulates during G1 and S phase in cell cycle, achieve the maximum in G2/M and drops after mitosis. The function of BUB1A is distinct during cell cycle, mainly in the SAC and chromosome alignment during metaphase. BUB1A can bind to Kinetochores and be involved in establishment of the mitotic spindle checkpoints and chromosome congression. Function loss or abnormal expression of BUB1A have been identified in a lot of human tumors, including colon, breast cancer, gastric and melanoma, which is correlated with the understanding that many cancers is associated with disturbed mitotic checkpoints (1).

Reference
1. Wikipdia Annotation:   BUB1