Protein Kinase Classification:      Other      BUB

※ BUB family introduction

    BUB family contains two serin/threonine protein kinases: BUB1A (BUB1) and BUB1B. BUB kinases comprise a conserved N-terminal region, followed by a non-conserved region and a kinase catalytic domain in C-terminal. N-terminal region is responsible for binding to mitotic kinetochore protein blinkin. Human BUB1A accumulates during G1 and S phase in cell cycle, achieve the maximum in G2/M and drops after mitosis. The function of BUB1A is distinct during cell cycle, mainly in the SAC and chromosome alignment during metaphase. BUB1A can bind to Kinetochores and be involved in establishment of the mitotic spindle checkpoints and chromosome congression. Function loss or abnormal expression of BUB1A have been identified in a lot of human tumors, including colon, breast cancer, gastric and melanoma, which is correlated with the understanding that many cancers is associated with disturbed mitotic checkpoints (1).

Reference
1. Wikipdia Annotation:   BUB1


Other BUB in eukaryotes:

Ailuropoda melanoleuca (2)Anolis carolinensis (2)Arabidopsis lyrata (1)
Arabidopsis thaliana (1)Bos taurus (2)Brachypodium distachyon (1)
Brassica rapa (1)Caenorhabditis elegans (1)Callithrix jacchus (2)
Canis familiaris (2)Cavia porcellus (2)Ciona intestinalis (1)
Ciona savignyi (1)Danio rerio (2)Drosophila melanogaster (2)
Equus caballus (2)Felis catus (2)Gadus morhua (1)
Gallus gallus (2)Gasterosteus aculeatus (1)Glycine max (2)
Gorilla gorilla (1)Homo sapiens (2)Hordeum vulgare (1)
Ictidomys tridecemlineatus (1)Latimeria chalumnae (1)Loxodonta africana (2)
Macaca mulatta (2)Meleagris gallopavo (2)Monodelphis domestica (2)
Mus musculus (2)Musa acuminata (1)Mustela putorius furo (3)
Myotis lucifugus (2)Nomascus leucogenys (2)Oreochromis niloticus (1)
Ornithorhynchus anatinus (2)Oryctolagus cuniculus (2)Oryza brachyantha (1)
Oryza glaberrima (1)Oryza indica (1)Oryza sativa (1)
Oryzias latipes (1)Otolemur garnettii (2)Pan troglodytes (2)
Pelodiscus sinensis (1)Petromyzon marinus (1)Physcomitrella patens (1)
Pongo abelii (2)Populus trichocarpa (1)Rattus norvegicus (2)
Saccharomyces cerevisiae (1)Sarcophilus harrisii (2)Schizosaccharomyces pombe (1)
Setaria italica (1)Solanum lycopersicum (1)Solanum tuberosum (1)
Sorghum bicolor (1)Sus scrofa (2)Taeniopygia guttata (2)
Takifugu rubripes (1)Tetraodon nigroviridis (1)Tursiops truncatus (1)
Vitis vinifera (1)Xenopus tropicalis (2)Zea mays (1)