Protein Kinase Classification:      Other      NAK

※ NAK family introduction

    NAK family is composed of four members. Family member MPSK is a membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. MPSK can also autophosphorylates. In addition, MPSK may be involved in secretory vesicle trafficking or intracellular signaling and may have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. AAK1, another member, regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. AAK1 can regulate phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (1).

Reference
1. UniProt Annotation:   STK16_HUMAN;   AAK1_HUMAN


Other NAK in eukaryotes:

Ailuropoda melanoleuca (4)Anolis carolinensis (3)Arabidopsis lyrata (2)
Arabidopsis thaliana (2)Bos taurus (3)Brachypodium distachyon (4)
Brassica rapa (5)Caenorhabditis elegans (2)Callithrix jacchus (4)
Canis familiaris (4)Cavia porcellus (4)Chlamydomonas reinhardtii (1)
Choloepus hoffmanni (1)Ciona intestinalis (3)Ciona savignyi (2)
Danio rerio (5)Dipodomys ordii (1)Drosophila melanogaster (3)
Echinops telfairi (1)Equus caballus (4)Felis catus (4)
Gadus morhua (3)Gallus gallus (4)Gasterosteus aculeatus (5)
Glycine max (4)Gorilla gorilla (4)Homo sapiens (4)
Hordeum vulgare (3)Ictidomys tridecemlineatus (4)Latimeria chalumnae (3)
Loxodonta africana (2)Macaca mulatta (3)Macropus eugenii (1)
Meleagris gallopavo (1)Microcebus murinus (1)Monodelphis domestica (4)
Mus musculus (4)Musa acuminata (6)Mustela putorius furo (4)
Myotis lucifugus (4)Nomascus leucogenys (4)Ochotona princeps (1)
Oreochromis niloticus (5)Ornithorhynchus anatinus (2)Oryctolagus cuniculus (4)
Oryza brachyantha (3)Oryza glaberrima (4)Oryza indica (4)
Oryza sativa (4)Oryzias latipes (5)Otolemur garnettii (4)
Pan troglodytes (4)Pelodiscus sinensis (4)Petromyzon marinus (3)
Physcomitrella patens (2)Pongo abelii (4)Populus trichocarpa (3)
Rattus norvegicus (4)Saccharomyces cerevisiae (4)Sarcophilus harrisii (4)
Schizosaccharomyces pombe (4)Selaginella moellendorffii (4)Setaria italica (4)
Solanum lycopersicum (4)Solanum tuberosum (4)Sorex araneus (1)
Sorghum bicolor (3)Sus scrofa (3)Taeniopygia guttata (4)
Takifugu rubripes (5)Tarsius syrichta (1)Tetraodon nigroviridis (3)
Tursiops truncatus (1)Vitis vinifera (2)Xenopus tropicalis (4)
Xiphophorus maculatus (5)Zea mays (4)