Protein Kinase Classification:      Other      NKF2

※ NKF2 family introduction

    NKF2 kinases belong to "Other" group. One member has been identified in human genome, PINK1 (PTEN-induced putative kinase protein 1). PINK1 gene encodes a 581-amino acid protein, which contains an N-terminal 34-amino acid mitochondrial targeting sequence (MTS), followed by a transmembrane domain (TMD) and a highly conserved kinase catalytic domain. PINK1 is a mitochondrial membrane integral protein and kinase domain localizes in the outer mitochondrial membrane and is accessible from the cytoplasm. The TMD domain is essential for anchoring PINK1 to the mitochondrial membrane and to ensure the kinase domain faces the cytoplasm. PINK1 function as a ser/thr protein kinase and mediate the phosphorylation of several substrates such as TRAP1, parkin, mTORC2 and so on. Abnormal expression or mutation of PINK1 will lead to diseases, for example PINK1-deficient Drosophila is associated with PD. In addition, PINK1 have been reported to be a key molecule in mitochondrial regulation (1).

Reference
1. Kawajiri, S., Saiki, S., Sato, S. and Hattori, N. (2011) Genetic mutations and functions of PINK1. Trends Pharmacol Sci, 32, 573-580. PMID: 21784538


Other NKF2 in eukaryotes:

Ailuropoda melanoleuca (1)Bos taurus (1)Caenorhabditis elegans (1)
Callithrix jacchus (1)Canis familiaris (1)Cavia porcellus (1)
Choloepus hoffmanni (1)Ciona savignyi (1)Danio rerio (1)
Dipodomys ordii (1)Drosophila melanogaster (1)Echinops telfairi (1)
Equus caballus (1)Felis catus (1)Gadus morhua (1)
Gallus gallus (1)Gasterosteus aculeatus (1)Gorilla gorilla (1)
Homo sapiens (1)Ictidomys tridecemlineatus (1)Latimeria chalumnae (1)
Loxodonta africana (1)Macaca mulatta (1)Monodelphis domestica (1)
Mus musculus (1)Mustela putorius furo (1)Myotis lucifugus (1)
Nomascus leucogenys (1)Ochotona princeps (1)Oreochromis niloticus (1)
Ornithorhynchus anatinus (1)Oryctolagus cuniculus (1)Oryzias latipes (1)
Otolemur garnettii (1)Pan troglodytes (1)Pelodiscus sinensis (1)
Pongo abelii (1)Rattus norvegicus (1)Sarcophilus harrisii (1)
Sorex araneus (1)Sus scrofa (1)Taeniopygia guttata (1)
Takifugu rubripes (1)Tetraodon nigroviridis (1)Tupaia belangeri (1)
Xiphophorus maculatus (1)