Protein Kinase Classification: Other NRBP※ NRBP family introduction NRBP (Nuclear receptor-binding protein) belong to the "Other" group (1). One member has been identified in human genome. NRBP may play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. NRBP binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (2).
Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Uniprot annotation: NRBP_HUMAN
Other NRBP in eukaryotes:
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Uniprot annotation: NRBP_HUMAN
Other NRBP in eukaryotes: