※ Slob family introduction

    Slob family contains one member in human genome which is known as PXK (PX domain-containing protein kinase-like protein). PXK consists of a ser/thr kinase catalytic domain, however several key residues that are important of intrinsic catalytic activity is absent. Human PXK have at four splice isoforms and each of them has a different subcellular localization. PXK can binds to and modulates brain Na, K-ATPase subunits ATP1B1 and ATP1B3 and play an critical role in regulation of electrical excitability and synaptic transmission (1,2).

Reference
1. Zou, X., G. Qiu, et al. (2005). "Expression pattern and subcellular localization of five splice isoforms of human PXK." Int J Mol Med 16(4): 701-707. PMID: 16142408
2. Uniprot annotation: PXK_HUMAN