Protein Kinase Classification:      Other      TOPK

※ TOPK family introduction

    TOPK (T-LAK cell-originated protein kinase), also known as MAPKK-like protein kinase, are classified into "Other" group (1). One member has been identified in human genome. TOPK was originally found in T-LAK-Cell substraction library, highly expressed in testicular tissue. TOPK plays an important role in spermatogenesis and also expresses in hematologic tumors, including leukemia, lymphoma and myeloma. TOPK can be phosphorylated by cdk1/cyclin B and is unregulated during mitosis. More functions remain to be further understood (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Matsumoto, S., Abe, Y., Fujibuchi, T., Takeuchi, T., Kito, K., Ueda, N., Shigemoto, K. and Gyo, K. (2004) Characterization of a MAPKK-like protein kinase TOPK. Biochem Biophys Res Commun, 325, 997-1004. PMID: 15541388.


Other TOPK in eukaryotes:

Ailuropoda melanoleuca (1)Anolis carolinensis (2)Bos taurus (2)
Callithrix jacchus (1)Canis familiaris (2)Cavia porcellus (1)
Ciona intestinalis (1)Ciona savignyi (1)Danio rerio (1)
Dipodomys ordii (1)Drosophila melanogaster (1)Echinops telfairi (1)
Equus caballus (1)Erinaceus europaeus (1)Felis catus (1)
Gadus morhua (1)Gallus gallus (1)Gasterosteus aculeatus (1)
Gorilla gorilla (1)Homo sapiens (1)Ictidomys tridecemlineatus (2)
Latimeria chalumnae (1)Loxodonta africana (1)Macaca mulatta (1)
Meleagris gallopavo (1)Monodelphis domestica (1)Mus musculus (1)
Mustela putorius furo (1)Myotis lucifugus (1)Nomascus leucogenys (1)
Oreochromis niloticus (1)Ornithorhynchus anatinus (1)Oryctolagus cuniculus (1)
Oryzias latipes (1)Otolemur garnettii (1)Pan troglodytes (1)
Pelodiscus sinensis (1)Pongo abelii (1)Rattus norvegicus (2)
Sarcophilus harrisii (1)Sus scrofa (1)Takifugu rubripes (1)
Tetraodon nigroviridis (1)Tupaia belangeri (1)Tursiops truncatus (1)
Vicugna pacos (1)Xenopus tropicalis (1)Xiphophorus maculatus (1)