※ TTK family introduction

    TTK is a mammalian homolog of conserved Mps1 family members expressed in all proliferating cells and tissues. TTK was original identified by screening of a T cell expression library with anti-phosphotyrosine antibodies. The C-terminal catalytic domains of TTKs show a high degree of sequence similarity and TTKs can function as both a ser/thr protein kinase and a tyrosine protein kinase. TTKs play an important role in regulation of cell cycle progression. Studies show that human TTK is required for human cells to undergo checkpoint arrest in response to microtubule depolymerization. In addition, TTK can exert its ecntrosome-based function by modulating TACC2 in mitosis (1).

Reference
1. Dou, Z., Ding, X., Zereshki, A., Zhang, Y., Zhang, J., Wang, F., Sun, J., Huang, H. and Yao, X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572, 51-56. PMID: 15304323