※ Ack family introduction

    Ack family is non-receptor tyrosine kinases. Two genes encode Ack have been found in human genome, known as TNK1 and Ack1 (TNK2). Sequence analysis of Acks show that Ack family consist of an N-terminal sterile alpha motif (SAM) domain, followed by a kinase catalytic domain and an SH3 domain. Certain Ack contains a Cdc2/Tac-interactive domain (CRIB). Acks are unique NRTKs with SH3 domain located c-terminal to kinase domain. The first member Ack1 was originally cloned from a human hippocampal expression library. Ack1 gene is located on chromosome 3q29 in human, where a region is associated with recurrence of prostate cancer and is a predictor of metastatic relapse in breast cancer.TNK1 was originally cloned from hematopoietic stem/progenitor cells. TNK1 have been reported to block NF-kB activation and promotes apoptosis mediated by TNFα signaling pathway (1).

Reference
1. Prieto-Echague, V. and Miller, W.T. (2011) Regulation of ack-family nonreceptor tyrosine kinases. J Signal Transduct, 2011, 742372. PMID: 21637378