Protein Kinase Classification:      TK      Met

※ Met family introduction

    Met kinase, also known HGF/SF receptor, belong to receptor tyrosine family. Met is a heterodimer containing an extracellular α-subunit which bond to a transmembrane β-subunit. The β-subunit also possess the intracellular catalytic activity. In addtion, extracellular regions also contain two functional regions, the PSI domain and four conserved IPT domains. The intracellular segment contains a Juxtamembrane sequence, a catalytic region and multifunctional docking sites. Several key tyrosine residues have been identified to be involved in kinase activation or recruitment of other transducers and adaptors. The Met is responsible for the signal transduction from cell membrane to cytoplasm via different signaling pathway, including the MAPK cascades, the PI3K-Akt axis, the STAT pathway and the IκBαCNF-κB pathway etc. Met singalings play an important roles in development and disease. Via signal transduction to distinct adaptors, Met mediate the regulation of embryonic development, organ regeneration and even tumorigenesis (1).

Reference
1. Trusolino, L., Bertotti, A. and Comoglio, P.M. (2010) MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol, 11, 834-848. PMID: 21102609


TK Met in eukaryotes:

Ailuropoda melanoleuca (2)Anolis carolinensis (2)Bos taurus (2)
Caenorhabditis elegans (2)Callithrix jacchus (2)Canis familiaris (2)
Cavia porcellus (2)Ciona intestinalis (1)Ciona savignyi (1)
Danio rerio (2)Echinops telfairi (1)Equus caballus (2)
Felis catus (2)Gallus gallus (2)Gasterosteus aculeatus (3)
Gorilla gorilla (2)Homo sapiens (2)Ictidomys tridecemlineatus (2)
Latimeria chalumnae (1)Loxodonta africana (2)Macaca mulatta (2)
Meleagris gallopavo (2)Monodelphis domestica (2)Mus musculus (2)
Mustela putorius furo (2)Myotis lucifugus (2)Nomascus leucogenys (2)
Ochotona princeps (1)Oreochromis niloticus (3)Ornithorhynchus anatinus (2)
Oryctolagus cuniculus (2)Oryzias latipes (3)Otolemur garnettii (1)
Pan troglodytes (2)Pelodiscus sinensis (1)Petromyzon marinus (1)
Pongo abelii (1)Pteropus vampyrus (1)Rattus norvegicus (2)
Sarcophilus harrisii (2)Sorex araneus (1)Sus scrofa (2)
Taeniopygia guttata (2)Takifugu rubripes (3)Tetraodon nigroviridis (3)
Vicugna pacos (1)Xenopus tropicalis (2)Xiphophorus maculatus (3)