Protein Kinase Classification:      TK      PDGFR

※ PDGFR family introduction

    PDGFR (Platelet-derived growth factor receptor) are receptor tyrosine kinase. Two different gene encoding PDGFR-A and PDGFR-B have been identified in human genome, both of which can interact with PDGFs to regulate diverse cellular processes. PDGFRs contain similar structure, including five extracellular immunoglobulin loops and an intracellular kinase domain. PDGFRs are original inactive in unstimulated cell environment. Ligand binding leads to the dimerization of PDGFR which will mediate the autophosphorylation on tyrosine residues in intracellular domain. Activate PDGFR subsequently target the downstream signaling molecules via the docking sites and further lead to the protein-protein interactions. Via targeting to distinct molecules, PDGFRs are involved in diverse signaling pathway, including JNK/SAPK and RAS/MAPK, and some secondary effectors such as Akt, JNK, PKC and p70S6K (1).

Reference
1. Andrae, J., Gallini, R. and Betsholtz, C. (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev, 22, 1276-1312. PMID: 18483217


TK PDGFR in eukaryotes:

Ailuropoda melanoleuca (5)Anolis carolinensis (6)Bos taurus (5)
Callithrix jacchus (5)Canis familiaris (5)Cavia porcellus (5)
Ciona intestinalis (1)Danio rerio (6)Equus caballus (5)
Felis catus (5)Gallus gallus (5)Gasterosteus aculeatus (3)
Gorilla gorilla (5)Homo sapiens (5)Ictidomys tridecemlineatus (5)
Latimeria chalumnae (4)Loxodonta africana (5)Macaca mulatta (5)
Meleagris gallopavo (5)Monodelphis domestica (5)Mus musculus (5)
Mustela putorius furo (5)Myotis lucifugus (5)Nomascus leucogenys (4)
Ochotona princeps (3)Oreochromis niloticus (7)Ornithorhynchus anatinus (7)
Oryctolagus cuniculus (5)Oryzias latipes (4)Otolemur garnettii (5)
Pan troglodytes (4)Pelodiscus sinensis (5)Petromyzon marinus (2)
Pongo abelii (5)Pteropus vampyrus (2)Rattus norvegicus (4)
Sarcophilus harrisii (6)Sus scrofa (6)Taeniopygia guttata (6)
Takifugu rubripes (6)Tetraodon nigroviridis (7)Tursiops truncatus (3)
Xenopus tropicalis (6)Xiphophorus maculatus (4)