Protein Kinase Classification:      TK      Ror

※ Ror family introduction

    ROR kinases are receptor tyrosin kinase. Two members have been identified in human genome, ROR1 and ROR2. Sequence analysis shows that RORs share conserved domain structure. The extracellular region contains a immunoglobulin domain, a cysteine-rich region and kringle domains. The intracellular region contains a tyrosine kinase domain and two serine and threonine rich region. Studies show ROR genes play an important role during development. ROR2 knockouts mouse display differentiation defects in growth plate, which suggests mROR2 is essential for regulation of proliferation. Function loss of ROR2 in human will cause the defects in endochondral bone formation. In C. elegans, ROR family has been found to be required for proper cell migration, development of ASI (1).

Reference
1. Forrester, W.C. (2002) The Ror receptor tyrosine kinase family. Cell Mol Life Sci, 59, 83-96. PMID: 11846036


TK Ror in eukaryotes:

Ailuropoda melanoleuca (2)Anolis carolinensis (2)Bos taurus (2)
Caenorhabditis elegans (1)Callithrix jacchus (3)Canis familiaris (2)
Cavia porcellus (2)Ciona intestinalis (2)Ciona savignyi (2)
Danio rerio (2)Dasypus novemcinctus (1)Dipodomys ordii (1)
Drosophila melanogaster (1)Equus caballus (2)Felis catus (2)
Gadus morhua (1)Gallus gallus (2)Gasterosteus aculeatus (2)
Gorilla gorilla (2)Homo sapiens (2)Ictidomys tridecemlineatus (2)
Latimeria chalumnae (2)Loxodonta africana (2)Macaca mulatta (2)
Meleagris gallopavo (2)Monodelphis domestica (2)Mus musculus (2)
Mustela putorius furo (2)Myotis lucifugus (2)Nomascus leucogenys (2)
Oreochromis niloticus (2)Ornithorhynchus anatinus (1)Oryctolagus cuniculus (2)
Oryzias latipes (1)Otolemur garnettii (2)Pan troglodytes (2)
Pelodiscus sinensis (2)Pongo abelii (2)Pteropus vampyrus (2)
Rattus norvegicus (2)Sarcophilus harrisii (2)Sorex araneus (1)
Sus scrofa (2)Taeniopygia guttata (2)Takifugu rubripes (2)
Tetraodon nigroviridis (1)Tupaia belangeri (1)Tursiops truncatus (1)
Xenopus tropicalis (2)Xiphophorus maculatus (1)