※ Ror family introduction

    ROR kinases are receptor tyrosin kinase. Two members have been identified in human genome, ROR1 and ROR2. Sequence analysis shows that RORs share conserved domain structure. The extracellular region contains a immunoglobulin domain, a cysteine-rich region and kringle domains. The intracellular region contains a tyrosine kinase domain and two serine and threonine rich region. Studies show ROR genes play an important role during development. ROR2 knockouts mouse display differentiation defects in growth plate, which suggests mROR2 is essential for regulation of proliferation. Function loss of ROR2 in human will cause the defects in endochondral bone formation. In C. elegans, ROR family has been found to be required for proper cell migration, development of ASI (1).

Reference
1. Forrester, W.C. (2002) The Ror receptor tyrosine kinase family. Cell Mol Life Sci, 59, 83-96. PMID: 11846036